Research Group

Florea Cristina
Ph.D., Medical engineering





Cell and cartilage biomechanics

Personal information

  • Email: cristina.florea[at]uef.fi

  • Date of birth: 12 May 1983

  • Current research interests: Cell and cartilage biomechanics, structural properties of bone in early osteoarthritis

  • Education:
    • Ph.D., double degree: Mechanical Engineering. Politehnica University of Timisoara, Romania and Medical Physics and Engineering. University of Eastern Finland, Kuopio, 2014
    • Medical Engineering, Politehnica University of Timisoara, Mechanical Engineering Faculty, Timisoara, Romania, 2008
    • Pedagogical High School "Carmen Sylva", Timisoara, Romania, 2003

  • Language proficiency:
    • Romanian, native language
    • English, fluent
    • Slovakian, fluent
    • German, intermediate
    • Spanish, basics
    • Finnish, basics

  • Skills:
    • Atomic force microscopy (AFM) and nanoindentation on living cells
    • Transmission electron miscroscopy (TEM)
    • Ultrasound imaging
    • AutoCAD, SolidWorks, Cosmos, Visual Basic, Solid Edge, Matlab, Mimics, Ansys, Abaqus

  • Hobbies: travelling, sports, dance, reading, photography

Publications:

(full papers, conference proceedings)
  1. Florea C, Tanska P, Mononen ME, Qu C, Lammi MJ, Laasanen MS, Korhonen RK A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells. Biomech Model Mechanobiol. 2017 Feb;16(1):297-311.doi: 10.1007/s10237-016-0817-y

  2. Florea C, Malo MKH, Rautiainen J, Mäkelä JTA, Fick JM, Nieminen MT, Jurvelin JS, Davidescu A, Korhonen RK Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2015 Mar;23(3):414-22. doi: 10.1016/j.joca.2014.11.023

  3. Näkki S, Rytkönen J, Nissinen T, Florea C, Riikonen J, Ek P, Zhang H, Santos HA, Närvänen A, Xu W, Lehto VP Improved stability and biocompatibility of nanostructured silicon drug carrier for intravenous administration. Acta Biomaterialia, 2015;13:207-215.

  4. Florea C, Jakorinne A, Lammi M, Davidescu A, Korhonen RK Determination of mechanical properties of chondrocytes in articular cartilage using Atomic Force Microscopy. Solid State Phenomena, 2014;216(5):134-139.

  5. Florea C, Berdich K, Dreucean M Topography Imaging of Material Surfaces Using Atomic Force Microscope. Solid State Phenomena, Advanced Materials and Structures, 2012;188(4):199-204.

  6. Florea C, Mononen ME, Fick J, Ylärinne J, Qu CJ, Lammi MJ, Korhonen RK, How does the actin cytoskeleton modulate the local elastic and time-dependent properties of chondrocytes during AFM nanoindentation? Transactions of the Orthopaedic Research Society, Las Vegas, USA, 2015.

  7. Florea C, Mononen ME, Tanska P, Lammi MJ, Korhonen RK, Intracellular Fluid Flow Controls Viscoelastic Properties of Chondrocytes in Nanoindentation. Transactions of the Orthopaedic Research Society, New Orleans, USA, 60:0434, 2014.

  8. Florea C, Malo MKH, Rautiainen J, Mäkelä J, Nieminen M, Jurvelin JS, Davidescu A, Korhonen R, Alterations in the Properties of Rabbit Articular Cartilage and Underlying Bone at 4 weeks After Anterior Cruciate Ligament Transection.8th Combined Meeting of Orthopaedic Research Societies (CORS), Venice, Italy, 2013 (oral presentation).

  9. Florea C, Dreucean M, Laasanen MS, Halvari A, Determination of Young’s Modulus using AFM Nanoindentation. Applications on Bone Structures. Conference E-Health and Bioengineering, Iasi, Romania, 2011.

Under review:

Contact: +358 20 7872211 (Switch), email: bbc-l [at] lists.uef.fi