Research Group

Hanna Isaksson
Adjunct professor (Docent)


Assistant professor, Lund University


Bone biomechanics

Personal information

  • Address: Department of Biomedical Engineering, Lund University, Lund, Sweden

  • Email: hanna.isaksson[at]bme.lth.se (please fix the address before mailing!)

  • Research areas and expertise:
    • Bone biomechanics, characterization methods, imaging techniques etc
    • Osteoporosis and aging
    • Bone healing, adaptation and remodeling
    • Mechanobiology of cell and tissue differentiation
    • Computational modeling and finite element analysis

  • Research experience:
    • Lund University, Sweden, 2011-current.
    • University of Eastern Finland, Finland, 2010.
    • University of Kuopio, Finland, 2008-2009.
    • AO Reserach Institute, Davos, Switzerland, 2003-2007
    • Eindhoven University of Technology, Netherlands 2003-2007.
    • University of Rochester, NY, USA 2002-2003.

  • Education:
    • Ph.D. Biomedical Engineering, Eindhoven University of Technology, Netherlands 2007.
    • Graduate studies, Biomedical Engineering and Material Science, University of Rochester, NY, USA 2002-2003
    • M.Sc. Chemical Engineering and Material Science, Uppsala University, Sweden 2003.

  • Language proficiency:
    • Swedish, native
    • English, fluent
    • German, good
    • Dutch, fairly good
    • Finnish, basic

Publications:

(full papers, conference proceedings)
  1. Mathavan N, ORCID: http://orcid.org/0000-0002-5900-1396, Turunen MJ, Guizar-Sicairos M, Bech M, ORCID: http://orcid.org/0000-0001-9109-7175, Schaff F, ORCID: http://orcid.org/0000-0003-2144-851X, Tagil M, Isaksson H and ORCID: http://orcid.org/0000-0002-9690-8907. The compositional and nano-structural basis of fracture healing in healthy and osteoporotic bone. Sci Rep. 2018 Jan 25;8(1):1591. doi: 10.1038/s41598-018-19296-z.

  2. Raina DB, Larsson D, Mrkonjic F, Isaksson H, Kumar A, Lidgren L and Tagil M. Gelatin- hydroxyapatite- calcium sulphate based biomaterial for long term sustained delivery of bone morphogenic protein-2 and zoledronic acid for increased bone formation: In-vitro and in-vivo carrier properties. J Control Release. 2018 Feb 28;272:83-96. doi: 10.1016/j.jconrel.2018.01.006.

  3. Ojanen X, Tanska P, Malo MKH, Isaksson H, Vaananen SP, Koistinen AP, Grassi L, Magnusson SP, Ribel-Madsen SM, Korhonen RK, Jurvelin JS and Toyras J. Tissue viscoelasticity is related to tissue composition but may not fully predict the apparent-level viscoelasticity in human trabecular bone - An experimental and finite element study. J Biomech. 2017 Dec 8;65:96-105. doi: 10.1016/j.jbiomech.2017.10.002. Epub 2017

  4. Khayyeri H, Blomgran P, ORCID: http://orcid.org/0000-0002-2654-1361, Hammerman M, Turunen MJ, Lowgren A, Guizar-Sicairos M, Aspenberg P and Isaksson H. Achilles tendon compositional and structural properties are altered after unloading by botox. Sci Rep. 2017 Oct 12;7(1):13067. doi: 10.1038/s41598-017-13107-7.

  5. Tong X, ORCID: http://orcid.org/0000-0002-7868-0478, Malo MKH, Burton IS, Jurvelin JS, Isaksson H and Kroger H. Histomorphometric and osteocytic characteristics of cortical bone in male subtrochanteric femoral shaft. J Anat. 2017 Nov;231(5):708-717. doi: 10.1111/joa.12670. Epub 2017 Aug 7.

  6. Le Cann S, Tudisco E, Perdikouri C, Belfrage O, Kaestner A, Hall S, Tagil M and Isaksson H. Characterization of the bone-metal implant interface by Digital Volume Correlation of in-situ loading using neutron tomography. J Mech Behav Biomed Mater. 2017 Nov;75:271-278. doi: 10.1016/j.jmbbm.2017.07.001.

  7. Isaksson H, Le Cann S, Perdikouri C, Turunen MJ, Kaestner A, Tagil M, Hall SA and Tudisco E. Neutron tomographic imaging of bone-implant interface: Comparison with X-ray tomography. Bone. 2017 Oct;103:295-301. doi: 10.1016/j.bone.2017.07.022. Epub 2017 Jul 22.

  8. Horstmann PF, Raina DB, Isaksson H, Hettwer W, Lidgren L, Petersen MM and Tagil M. (*) Composite Biomaterial as a Carrier for Bone-Active Substances for Metaphyseal Tibial Bone Defect Reconstruction in Rats. Tissue Eng Part A. 2017 Dec;23(23-24):1403-1412. doi: 10.1089/ten.TEA.2017.0040.

  9. Tong X, Burton IS, Jurvelin JS, Isaksson H and Kroger H. Iliac crest histomorphometry and skeletal heterogeneity in men. Bone Rep. 2016 Nov 28;6:9-16. doi: 10.1016/j.bonr.2016.11.004. eCollection 2017

  10. Teotia AK, Raina DB, Singh C, Sinha N, Isaksson H, Tagil M, Lidgren L, Kumar A and ORCID: http://orcid.org/0000-0002-4910-9440. Nano-Hydroxyapatite Bone Substitute Functionalized with Bone Active Molecules for Enhanced Cranial Bone Regeneration. ACS Appl Mater Interfaces. 2017 Mar 1;9(8):6816-6828. doi:

  11. Grassi L, ORCID: 0000-0001-7824-9947, Vaananen SP, Ristinmaa M, Jurvelin JS and Isaksson H. Prediction of femoral strength using 3D finite element models reconstructed from DXA images: validation against experiments. Biomech Model Mechanobiol. 2017 Jun;16(3):989-1000. doi:

  12. Ojanen X, Toyras J, Inkinen SI, Malo MK, Isaksson H and Jurvelin JS. Differences in acoustic impedance of fresh and embedded human trabecular bone samples-Scanning acoustic microscopy and numerical evaluation. J Acoust Soc Am. 2016 Sep;140(3):1931. doi: 10.1121/1.4962347.

  13. Mathavan N, ORCID: 0000-0002-5900-1396, Tagil M and Isaksson H. Do osteoporotic fractures constitute a greater recalcitrant challenge for skeletal regeneration? Investigating the efficacy of BMP-7 and zoledronate treatment of diaphyseal fractures in an open fracture osteoporotic rat model. Osteoporos Int. 2017 Feb;28(2):697-707. doi: 10.1007/s00198-016-3771-8. Epub 2016

  14. Turunen MJ, Kaspersen JD, Olsson U, Guizar-Sicairos M, Bech M, Schaff F, Tagil M, Jurvelin JS and Isaksson H. Bone mineral crystal size and organization vary across mature rat bone cortex. J Struct Biol. 2016 Sep;195(3):337-344. doi: 10.1016/j.jsb.2016.07.005. Epub 2016

  15. Raina DB, Isaksson H, Teotia AK, Lidgren L, Tagil M and Kumar A. Biocomposite macroporous cryogels as potential carrier scaffolds for bone active agents augmenting bone regeneration. J Control Release. 2016 Aug 10;235:365-378. doi: 10.1016/j.jconrel.2016.05.061.

  16. Raina DB, Isaksson H, Hettwer W, Kumar A, Lidgren L and Tagil M. A Biphasic Calcium Sulphate/Hydroxyapatite Carrier Containing Bone Morphogenic Protein-2 and Zoledronic Acid Generates Bone. Sci Rep. 2016 May 18;6:26033. doi: 10.1038/srep26033.

  17. Gustafsson A, Schilcher J, Grassi L, Aspenberg P and Isaksson H. Strains caused by daily loading might be responsible for delayed healing of an incomplete atypical femoral fracture. Bone. 2016 Jul;88:125-130. doi: 10.1016/j.bone.2016.04.020. Epub 2016 Apr 22.

  18. Grassi L, Vaananen SP, Ristinmaa M, Jurvelin JS and Isaksson H. How accurately can subject-specific finite element models predict strains and strength of human femora? Investigation using full-field measurements. J Biomech. 2016 Mar 21;49(5):802-806. doi: 10.1016/j.jbiomech.2016.02.032. Epub

  19. Vaananen SP, Grassi L, Flivik G, Jurvelin JS and Isaksson H. Generation of 3D shape, density, cortical thickness and finite element mesh of proximal femur from a DXA image. Med Image Anal. 2015 Aug;24(1):125-134. doi: 10.1016/j.media.2015.06.001. Epub

  20. Khayyeri H, Gustafsson A, Heuijerjans A, Matikainen MK, Julkunen P, Eliasson P, Aspenberg P and Isaksson H. A fibre-reinforced poroviscoelastic model accurately describes the biomechanical behaviour of the rat Achilles tendon. PLoS One. 2015 Jun 1;10(6):e0126869. doi: 10.1371/journal.pone.0126869.

  21. Mathavan N, Turunen MJ, Tagil M and Isaksson H. Characterising bone material composition and structure in the ovariectomized (OVX) rat model of osteoporosis. Calcif Tissue Int. 2015 Aug;97(2):134-44. doi: 10.1007/s00223-015-9991-7. Epub

  22. Tong X, Burton IS, Isaksson H, Jurvelin JS and Kroger H. Cortical bone histomorphometry in male femoral neck: the investigation of age-association and regional differences. Calcif Tissue Int. 2015 Apr;96(4):295-306. doi: 10.1007/s00223-015-9957-9. Epub

  23. Bosemark P, Perdikouri C, Pelkonen M, Isaksson H and Tagil M. The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect. J Orthop Res. 2015 Apr;33(4):488-95. doi: 10.1002/jor.22815. Epub 2015 Feb 12.

  24. Perdikouri C, Tagil M and Isaksson H. Characterizing the composition of bone formed during fracture healing using scanning electron microscopy techniques. Calcif Tissue Int. 2015 Jan;96(1):11-7. doi: 10.1007/s00223-014-9930-z. Epub 2014

  25. Ojanen X, Isaksson H, Toyras J, Turunen MJ, Malo MK, Halvari A and Jurvelin JS. Relationships between tissue composition and viscoelastic properties in human trabecular bone. J Biomech. 2015 Jan 21;48(2):269-75. doi: 10.1016/j.jbiomech.2014.11.034. Epub

  26. Moverare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Borjesson AE, Sjogren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, ORCID: 0000000218208518, Lindholm C, Sandberg O, Aspenberg P, Savendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F and Ohlsson C. Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. Nat Med. 2014 Nov;20(11):1279-88. doi: 10.1038/nm.3654. Epub 2014 Oct 12.

  27. Grassi L, Vaananen SP, Yavari SA, Jurvelin JS, Weinans H, Ristinmaa M, Zadpoor AA and Isaksson H. Full-field strain measurement during mechanical testing of the human femur at physiologically relevant strain rates. J Biomech Eng. 2014 Nov;136(11). pii: 1901145. doi: 10.1115/1.4028415.

  28. Schilcher J, Sandberg O, Isaksson H and Aspenberg P. Histology of 8 atypical femoral fractures: remodeling but no healing. Acta Orthop. 2014 Jun;85(3):280-6. doi: 10.3109/17453674.2014.916488. Epub 2014

  29. Malo MK, Toyras J, Karjalainen JP, Isaksson H, Riekkinen O and Jurvelin JS. Ultrasound backscatter measurements of intact human proximal femurs--relationships of ultrasound parameters with tissue structure and mineral density. Bone. 2014 Jul;64:240-5. doi: 10.1016/j.bone.2014.04.014. Epub 2014 Apr 24.

  30. Tong XY, Malo M, Tamminen IS, Isaksson H, Jurvelin JS and Kroger H. Development of new criteria for cortical bone histomorphometry in femoral neck: intra- and inter-observer reproducibility. J Bone Miner Metab. 2015 Jan;33(1):109-18. doi: 10.1007/s00774-014-0562-1. Epub

  31. Tamminen IS, Valta H, Jalanko H, Salminen S, Mayranpaa MK, Isaksson H, Kroger H and Makitie O. Pediatric solid organ transplantation and osteoporosis: a descriptive study on bone histomorphometric findings. Pediatr Nephrol. 2014 Aug;29(8):1431-40. doi: 10.1007/s00467-014-2771-1. Epub

  32. Bosemark P, Isaksson H and Tagil M. Influence of systemic bisphosphonate treatment on mechanical properties of BMP-induced calluses in a rat fracture model: comparison of three-point bending and twisting test. J Orthop Res. 2014 May;32(5):721-6. doi: 10.1002/jor.22599. Epub 2014 Feb 13.

  33. Turunen MJ, Lages S, Labrador A, Olsson U, Tagil M, Jurvelin JS and Isaksson H. Evaluation of composition and mineral structure of callus tissue in rat femoral fracture. J Biomed Opt. 2014 Feb;19(2):025003. doi: 10.1117/1.JBO.19.2.025003.

  34. Koistinen AP, Halmesmaki EP, Iivarinen JT, Arokoski JP, Brama PA, Jurvelin JS, Helminen HJ and Isaksson H. Short-term exercise-induced improvements in bone properties are for the most part not maintained during aging in hamsters. Exp Gerontol. 2014 Mar;51:46-53. doi: 10.1016/j.exger.2013.12.017. Epub 2014 Jan

  35. Tamminen IS, Misof BM, Roschger P, Mayranpaa MK, Turunen MJ, Isaksson H, Kroger H, Makitie O and Klaushofer K. Increased heterogeneity of bone matrix mineralization in pediatric patients prone to fractures: a biopsy study. J Bone Miner Res. 2014;29(5):1110-7. doi: 10.1002/jbmr.2124.

  36. Zampelis V, Tagil M, Lidgren L, Isaksson H, Atroshi I and Wang JS. The effect of a biphasic injectable bone substitute on the interface strength in a rabbit knee prosthesis model. J Orthop Surg Res. 2013 Jul 31;8:25. doi: 10.1186/1749-799X-8-25.

  37. Mathavan N, Bosemark P, Isaksson H and Tagil M. Investigating the synergistic efficacy of BMP-7 and zoledronate on bone allografts using an open rat osteotomy model. Bone. 2013 Oct;56(2):440-8. doi: 10.1016/j.bone.2013.06.030. Epub 2013 Jul 9.

  38. Vaananen SP, Amin Yavari S, Weinans H, Zadpoor AA, Jurvelin JS and Isaksson H. Repeatability of digital image correlation for measurement of surface strains in composite long bones. J Biomech. 2013 Jul 26;46(11):1928-32. doi: 10.1016/j.jbiomech.2013.05.021. Epub

  39. Julkunen P, Wilson W, Isaksson H, Jurvelin JS, Herzog W and Korhonen RK. A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading. Comput Math Methods Med. 2013;2013:326150. doi: 10.1155/2013/326150. Epub 2013

  40. Tamminen IS, Yli-Kyyny T, Isaksson H, Turunen MJ, Tong X, Jurvelin JS and Kroger H. Incidence and bone biopsy findings of atypical femoral fractures. J Bone Miner Metab. 2013 Sep;31(5):585-94. doi: 10.1007/s00774-013-0448-7. Epub

  41. Grassi L, Vaananen SP, Amin Yavari S, Weinans H, Jurvelin JS, Zadpoor AA and Isaksson H. Experimental validation of finite element model for proximal composite femur using optical measurements. J Mech Behav Biomed Mater. 2013 May;21:86-94. doi: 10.1016/j.jmbbm.2013.02.006.

  42. Bosemark P, Isaksson H, McDonald MM, Little DG and Tagil M. Augmentation of autologous bone graft by a combination of bone morphogenic protein and bisphosphonate increased both callus volume and strength. Acta Orthop. 2013 Feb;84(1):106-11. doi: 10.3109/17453674.2013.773123.

  43. Turunen MJ, Prantner V, Jurvelin JS, Kroger H and Isaksson H. Composition and microarchitecture of human trabecular bone change with age and differ between anatomical locations. Bone. 2013 May;54(1):118-25. doi: 10.1016/j.bone.2013.01.045. Epub 2013 Feb 4.

  44. Malo MK, Rohrbach D, Isaksson H, Toyras J, Jurvelin JS, Tamminen IS, Kroger H and Raum K. Longitudinal elastic properties and porosity of cortical bone tissue vary with age in human proximal femur. Bone. 2013 Apr;53(2):451-8. doi: 10.1016/j.bone.2013.01.015. Epub 2013 Jan 17.

  45. Kobrina Y, Rieppo L, Saarakkala S, Pulkkinen HJ, Tiitu V, Valonen P, Kiviranta I, Jurvelin JS and Isaksson H. Cluster analysis of infrared spectra can differentiate intact and repaired articular cartilage. Osteoarthritis Cartilage. 2013 Mar;21(3):462-9. doi: 10.1016/j.joca.2012.12.005.

  46. Belfrage O, Isaksson H and Tagil M. Local treatment of a bone graft by soaking in zoledronic acid inhibits bone resorption and bone formation. A bone chamber study in rats. BMC Musculoskelet Disord. 2012 Dec 5;13:240. doi: 10.1186/1471-2474-13-240.

  47. Vaananen SP, Isaksson H, Waarsing JH, Zadpoor AA, Jurvelin JS and Weinans H. Estimation of 3D rotation of femur in 2D hip radiographs. J Biomech. 2012 Aug 31;45(13):2279-83. doi: 10.1016/j.jbiomech.2012.06.007. Epub

  48. Kobrina Y, Rieppo L, Saarakkala S, Jurvelin JS and Isaksson H. Clustering of infrared spectra reveals histological zones in intact articular cartilage. Osteoarthritis Cartilage. 2012 May;20(5):460-8. doi: 10.1016/j.joca.2012.01.014.

  49. Agholme F, Isaksson H, Li X, Ke HZ and Aspenberg P. Anti-sclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats. Acta Orthop. 2011 Oct;82(5):628-32. doi: 10.3109/17453674.2011.625539.

  50. Vaananen SP, Jurvelin JS and Isaksson H. Estimation of 3D shape, internal density and mechanics of proximal femur by combining bone mineral density images with shape and density templates. Biomech Model Mechanobiol. 2012 Jul;11(6):791-800. doi:

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