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Laboratory engineer

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Research Group


Janne Toivo August Mäkelä, Ph.D.

Research Fellow


Articular Cartilage Tribology

Contrast-Enhanced Computed Tomography

Personal information

  • Email: janne . makela [at] uef . fi (please fix the address before mailing!)
  • ResearchGate: [link]

  • Past research interests: Structure-function relationships in osteoarthritic articular cartilage.

  • Education:
    • PhD, Medical Physics, University of Eastern Finland, 2016
    • Master of Science, Medical Physics, University of Eastern Finland, 2011
    • Graduate of Finnish Upper Secondary School, Kuopion Lyseon lukio, 2001

  • Language proficiency:
    • Finnish, native language
    • English, fluent
    • Swedish, good

  • Skills: Finite element modeling (Abaqus-software); Mechanical, microscopical and spectroscopical measurements and analysis: Digital densitometry, Polarized microscopy, Fourier transform infrared imaging, Raman; Animal models; Programming languages: Matlab, Java, HTML.

Publications (Citation statistics):

(full papers, Conference proceedings [ORS])

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  1. Petri Tanska, Mithilesh Prakash, Janne T.A. Mäkelä, Jaakko K. Sarin, Juha Töyräs, Isaac O. Afara, Rami K. Korhonen. Estimation of Constituent-Specific Mechanical Material Properties of Human Articular Cartilage from Near-Infrared Spectroscopy. Transactions of the Orthopaedic Research Society 45:2444, 2020.

  2. Mikael J. Turunen, Abhisek Bhattarai, Mark Grinstaff, Juha Töyräs, Janne TA Mäkelä. Effect Of Human Articular Cartilage Constituents On Simultaneous Diffusion Of Cationic And Non-ionic Contrast Agents. Transactions of the Orthopaedic Research Society 45:2339, 2020.

  3. N.C.R. te Moller, A. Mohammadi, S. Plomp, M. Beukers, B. Pouran, J.T.A. Mäkelä, R.K. Korhonen, J. Töyräs, H. Brommer, P.R. van Weeren. Articular cartilage response to blunt vs sharp lesions in an in vivo equine carpal groove model. OARSI World Congress on Osteoarthritis. 2020

  4. Mikael J. Turunen, Nikae C.R. te Moller, Ali Mohammadi, Janne T.A. Mäkelä, Arto P. Koistinen, Paul R. van Weeren. Compositional Changes in Subchondral Bone an Calcified Cartilage in an Equine Cartilage defect Model - a Pilot Study. European Conference on Spectroscopy of Biological Molecules (ECSBM), 2019.

  5. Nikae C.R. te Moller, Ali Mohammadi, Janne T.A. Mäkelä, Rami Korhonen, Behdad Pouran, Martijn Beukers, Saskia Plomp, Harold Brommer, P. René van Weeren. Progression of chondral lesions and signs of osteoarthritic changes in a long term equine carpal groove model. NVMB - Dutch Society for Matrix Biology, Annual Meeting 2019.

  6. B. Nelson, J. Makela, T. Lawson, A. Patwa, M. Barrett, W. McIlwraith, M. Hurtig, B. Snyder, V. Moorman, M. Grinstaff, L. Goodrich, C. Kawcak. Cationic contrast enhanced computed tomography depicts articular cartilage properties following impact injury. ICRS Vancouver, 2019.

  7. Mäkelä JTA, Patwa AN, Töyräs J, Snyder BD, Grinstaff MW. Effect Of Molecule Structure To The Diffusion Of The Cationic Contrast Agent CA4+. Transactions of the Orthopaedic Research Society 44:228, 2019.

  8. Honkanen MKM, Saukko AEA, Turunen MJ, Shaikh R, Prakash M, Lovric G, Mäkelä JTA, Grinstaff MW, Töyräs J. Synchrotron µCT Reveals the Potential of the Dual-Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition. Transactions of the Orthopaedic Research Society 44:2082, 2019

  9. Bordeianu C, Parambath A, Mäkelä JTA, Lawson T, Abbina S, Nelson BB, Snyder BD, Kizhakkedathu JN, Grinstaff MW. Ultra high molecular weight hyperbranched polyglycerol in articular cartilage lubrication. 256th ACS National Meeting in Boston, MA, August 19-22.2018.

  10. Nelson BB, Mäkelä JTA, Lawson TB, Patwa AN, Snyder BD, Grinstaff MW, Goodrich LR, Kawcak CE. Cationic Contrast-Enhanced Computed Tomography Biomarkers Distinguish Reparative and Degenerative Articular Cartilage in an Equine Model. Transactions of the Orthopaedic Research Society 43:37, 2018.

  11. Mäkelä JTA, Lawson TB, Bordeianu C, Nelson BB, Parambath Anilkumar, Abbina S, Kizhakkedathu JN, Grinstaff MW, Snyder BD. High Molecular Weight Hyperbranched Polyglycerol In Articular Cartilage Lubrication. Transactions of the Orthopaedic Research Society 43:38, 2018.

  12. Mäkelä JTA, Cooper BG, Korhonen RK, Grinstaff MW, Snyder BD. a Unifying Framework For Evaluating Cartilage Lubrication: Expressing The Stribeck Curve As A Function Of Interstitial Fluid Load Support Derived From Finite Element Analysis. Transactions of the Orthopaedic Research Society 43:102, 2018.

  13. Ojanen SP, Finnilä MAJ, Saarela K, Mäkelä JTA, Herzog W, Saarakkala S, Korhonen RK, ACL transection of rabbits alter FCD content, tissue modulus and cell deformation mostly in the lateral femoral condyle cartilage 2 weeks post-surgery. Transactions of the Orthopaedic Research Society, 43: 512, 2018.

  14. Sabuhi WA, Mäkelä JTA, Snyder BD, Grinstaff MW, Characterization of a Synthetic Polymer Biolubricant in an Ex Vivo Rotational Cartilage Mechanical Model. Transactions of the Orthopaedic Research Society 43:1339, 2018.

  15. Ojanen SP, Finnilä MAJ, Saarela K, Mäkelä JTA, Herzog W, Saarakkala S, Korhonen RK, ACLT of Rabbits Alters PG Content and Cartilage Biomechanics Two Weeks Post-surgery. 15th Science day of the Campus of Kontikangas, February 2018.

  16. Ojanen S, Finnilä M, Mäkelä JTA, Saarela K, Happonen E, Herzog W, Saarakkala S, Korhonen RK. Site-specific changes of articular cartilage bioechanics and chondrocyte deformation in early OA. 23rd Congress of the European Society of Biomechancis, Seville, Spain, 2017.

  17. Mäkelä JTA, Cooper BG, Korhonen RK, Grinstaff MW, Snyder BD. Novel Interpenetrating Hydrogel Reconstitutes Articular Cartilage Mechanical Properties. Transactions of the Orthopaedic Research Society 42: 2283, 2017

  18. Nelson BB, Mäkelä JTA, Lawson TB, Snyder BD Hurtig MB, Moorman VJ, Grinstaff MW, Goodrich LR, Kawcak, CE. Cationic Contrast-Enhanced Computed Tomography Detects Subtle Equine Articular Cartilage Damage After Impact Injury and Reflects Biomechanical Properties. Transactions of the Orthopaedic Research Society 42: 1384, 2017

  19. Mäkelä JTA, Cooper BG, Grinstaff MW, Snyder BD. A unifying framework for evaluating cartilage friction and lubrication mode: Expressing the Stribeck curve as a funtion of interstitial fluid load support. Transactions of the Orthopaedic Research Society 42: 0469, 2017

  20. Drezek K, Jeyaram A, Sabuhi WA, Mäkelä JTA, Cooper BG, Snyder BD, Grinstaff MW. pMPC, a Synthetic Crosslinked Polymer Biolubricant. 43rd Northeast Bioengineering Conference (NEBEC), 2017

  21. Mäkelä JTA, Han S-K, Herzog W, Korhonen RK. Fluid flow properties of articular cartilage change most in very early osteoarthritis. Transactions of the Orthopaedic Research Society 40: 0791, 2015

  22. Danso EK, Mäkelä JA, Tanska P, Mononen ME, Honkanen JTJ, Jurvelin JS, Töyräs J, Julkunen P, Korhonen RK. Site-Specific Biomechanical Properties of Human Meniscus. Transactions of the Orthopaedic Research Society 40: 0249, 2015

  23. Mäkelä JTA, Herzog W, Korhonen RK. Collagen content is increased in lapine femoral condyle cartilage four weeks after anterior cruciate ligament transection. Transactions of the Orthopaedic Research Society 39: 1226, 2014.

  24. Florea C, Malo MKH, Rautiainen J, Mäkelä J, Nieminen M, Jurvelin JS, Davidescu A, Korhonen R, Alterations in the Properties of Rabbit Articular Cartilage and Underlying Bone at 4 weeks After Anterior Cruciate Ligament Transection.8th Combined Meeting of Orthopaedic Research Societies (CORS), Venice, Italy, 2013.

  25. Mäkelä JTA, Rezaeian ZS, Mikkonen S, Madden R, Han S-K, Jurvelin JS, Herzog W, Korhonen RK. Site-dependent changes in collagen orientation and elastic moduli in lapine articular cartilage at 4 weeks after anterior cruciate ligament transection. Transactions of the Orthopaedic Research Society 38: 1280, 2013.

  26. Mäkelä JTA, Huttu MRJ, Korhonen RK. Structure-function relationships in osteoarthritic human articular cartilage. Transactions of the Orthopaedic Research Society 37: 1800, 2012.

  27. Huttu MRJ, Puhakka J, Mäkelä JTA, Takakubo Y, Tiitu V, Saarakkala S, Konttinen YT, Kiviranta I, Korhonen RK. Relationships between cell volume, structure, composition and mechanical properties of osteoarthritic human hip articular cartilage. Transactions of the Orthopaedic Research Society 37: 1823, 2012.

Acknowledged technical contributions:

  1. Stewart RC, Honkanen JTJ, Kokkonen HT, Tiitu V, Saarakkala S, Joukainen A, Snyder BD, Jurvelin JS, Grinstaff MW, Toyras J, Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage Cartilage. 2017 Oct;8(4):391-399.

  2. Florea C, Tanska P, Mononen ME, Qu C, Lammi MJ, Laasanen MS, Korhonen RK. A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells. Biomech Model Mechanobiol. 16(1):297-311, 2017.

  3. Muhonen V, Salonius E, Haaparanta AM, Järvinen E, Paatela T, Meller A, Hannula M, Björkman M, Pyhältö T, Ellä V, Vasara A, Töyräs J, Kellomäki M, Kiviranta I, Articular cartilage repair with recombinant human type II collagen/polylactide scaffold in a preliminary porcine study. J Orthop Res. 2016 May;34(5):745-53.

Popularised articles:

  1. Mäkelä JTA, Kudosnesteen virtauksen muutokset nivelrustossa voivat ennustaa nivelrikon alkamista. Niveltieto 2/2016:11-13, Suomen nivelyhdistys ry.

  2. Elizabeth Hofheinz, Mäkelä JTA, Predict onset of OA with fluid flow, Orthopedics This Week, 21.2.2016

Contact: +358 29 4451111 (Switch), email: bbc-l [at] lists.uef.fi