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Laboratory engineer

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Research Group


Janne Toivo August Mäkelä, Ph.D.

Research Fellow


Articular Cartilage Tribology

Contrast-Enhanced Computed Tomography

Personal information

  • Email: janne . makela [at] uef . fi (please fix the address before mailing!)
  • ResearchGate: [link]

  • Past research interests: Structure-function relationships in osteoarthritic articular cartilage.

  • Education:
    • PhD, Medical Physics, University of Eastern Finland, 2016
    • Master of Science, Medical Physics, University of Eastern Finland, 2011
    • Graduate of Finnish Upper Secondary School, Kuopion Lyseon lukio, 2001

  • Language proficiency:
    • Finnish, native language
    • English, fluent
    • Swedish, good

  • Skills: Finite element modeling (Abaqus-software); Mechanical, microscopical and spectroscopical measurements and analysis: Digital densitometry, Polarized microscopy, Fourier transform infrared imaging, Raman; Animal models; Programming languages: Matlab, Java, HTML.

Publications (Citation statistics):

(full papers, Conference proceedings [ORS])
  1. Ojanen SP, Finnila MAJ, Makela JTA, Saarela K, Happonen E, Herzog W, Saarakkala S and Korhonen RK. Anterior cruciate ligament transection of rabbits alters composition, structure and biomechanics of articular cartilage and chondrocyte deformation 2weeks post-surgery in a site-specific manner. J Biomech. 2019 Oct 23:109450. doi: 10.1016/j.jbiomech.2019.109450.

  2. Nelson BB, Makela JTA, Lawson TB, Patwa AN, Barrett MF, McIlwraith CW, Hurtig MB, Snyder BD, Moorman VJ, Grinstaff MW, Goodrich LR and Kawcak CE. Evaluation of equine articular cartilage degeneration after mechanical impact injury using cationic contrast-enhanced computed tomography. Osteoarthritis Cartilage. 2019 Aug;27(8):1219-1228. doi:

  3. Makela JTA, Cooper BG, Korhonen RK, Grinstaff MW and Snyder BD. Functional effects of an interpenetrating polymer network on articular cartilage mechanical properties. Osteoarthritis Cartilage. 2018 Mar;26(3):414-421. doi:

  4. Makela JTA and Korhonen RK. Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity. J Biomech. 2016 Jun 14;49(9):1734-1741. doi: 10.1016/j.jbiomech.2016.04.002. Epub

  5. Makela JT, Han SK, Herzog W and Korhonen RK. Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage. J Biomech. 2015 Sep 18;48(12):3369-76. doi: 10.1016/j.jbiomech.2015.06.010. Epub

  6. Puhakka PH, Te Moller NCR, Afara IO, Makela JTA, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. Osteoarthritis Cartilage. 2015 Dec;23(12):2206-2213. doi:

  7. Danso EK, Makela JT, Tanska P, Mononen ME, Honkanen JT, Jurvelin JS, Toyras J, Julkunen P and Korhonen RK. Characterization of site-specific biomechanical properties of human meniscus-Importance of collagen and fluid on mechanical nonlinearities. J Biomech. 2015 Jun 1;48(8):1499-507. doi: 10.1016/j.jbiomech.2015.01.048. Epub

  8. Florea C, Malo MK, Rautiainen J, Makela JT, Fick JM, Nieminen MT, Jurvelin JS, Davidescu A and Korhonen RK. Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2015 Mar;23(3):414-22. doi: 10.1016/j.joca.2014.11.023.

  9. Makela JT, Rezaeian ZS, Mikkonen S, Madden R, Han SK, Jurvelin JS, Herzog W and Korhonen RK. Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2014 Jun;22(6):869-78. doi: 10.1016/j.joca.2014.04.010.

  10. Huttu MR, Puhakka J, Makela JT, Takakubo Y, Tiitu V, Saarakkala S, Konttinen YT, Kiviranta I and Korhonen RK. Cell-tissue interactions in osteoarthritic human hip joint articular cartilage. Connect Tissue Res. 2014 Aug;55(4):282-91. doi: 10.3109/03008207.2014.912645.

  11. Makela JT, Huttu MR and Korhonen RK. Structure-function relationships in osteoarthritic human hip joint articular cartilage. Osteoarthritis Cartilage. 2012 Nov;20(11):1268-77. doi:

  12. Kokkonen HT, Makela J, Kulmala KA, Rieppo L, Jurvelin JS, Tiitu V, Karjalainen HM, Korhonen RK, Kovanen V and Toyras J. Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage. Osteoarthritis Cartilage. 2011 Oct;19(10):1190-8. doi:

  1. Mikael J. Turunen, Nikae C.R. te Moller, Ali Mohammadi, Janne T.A. Mäkelä, Arto P. Koistinen, Paul R. van Weeren. Compositional Changes in Subchondral Bone an Calcified Cartilage in an Equine Cartilage defect Model - a Pilot Study. European Conference on Spectroscopy of Biological Molecules (ECSBM), 2019.

  2. Nikae C.R. te Moller, Ali Mohammadi, Janne T.A. Mäkelä, Rami Korhonen, Behdad Pouran, Martijn Beukers, Saskia Plomp, Harold Brommer, P. René van Weeren. Progression of chondral lesions and signs of osteoarthritic changes in a long term equine carpal groove model. NVMB - Dutch Society for Matrix Biology, Annual Meeting 2019.

  3. B. Nelson, J. Makela, T. Lawson, A. Patwa, M. Barrett, W. McIlwraith, M. Hurtig, B. Snyder, V. Moorman, M. Grinstaff, L. Goodrich, C. Kawcak. Cationic contrast enhanced computed tomography depicts articular cartilage properties following impact injury. ICRS Vancouver, 2019.

  4. Mäkelä JTA, Patwa AN, Töyräs J, Snyder BD, Grinstaff MW. Effect Of Molecule Structure To The Diffusion Of The Cationic Contrast Agent CA4+. Transactions of the Orthopaedic Research Society 44:228, 2019.

  5. Honkanen MKM, Saukko AEA, Turunen MJ, Shaikh R, Prakash M, Lovric G, Mäkelä JTA, Grinstaff MW, Töyräs J. Synchrotron µCT Reveals the Potential of the Dual-Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition. Transactions of the Orthopaedic Research Society 44:2082, 2019

  6. Nelson BB, Mäkelä JTA, Lawson TB, Patwa AN, Snyder BD, Grinstaff MW, Goodrich LR, Kawcak CE. Cationic Contrast-Enhanced Computed Tomography Biomarkers Distinguish Reparative and Degenerative Articular Cartilage in an Equine Model. Transactions of the Orthopaedic Research Society 43:37, 2018.

  7. Mäkelä JTA, Lawson TB, Bordeianu C, Nelson BB, Parambath Anilkumar, Abbina S, Kizhakkedathu JN, Grinstaff MW, Snyder BD. High Molecular Weight Hyperbranched Polyglycerol In Articular Cartilage Lubrication. Transactions of the Orthopaedic Research Society 43:38, 2018.

  8. Mäkelä JTA, Cooper BG, Korhonen RK, Grinstaff MW, Snyder BD. a Unifying Framework For Evaluating Cartilage Lubrication: Expressing The Stribeck Curve As A Function Of Interstitial Fluid Load Support Derived From Finite Element Analysis. Transactions of the Orthopaedic Research Society 43:102, 2018.

  9. Ojanen SP, Finnilä MAJ, Saarela K, Mäkelä JTA, Herzog W, Saarakkala S, Korhonen RK, ACL transection of rabbits alter FCD content, tissue modulus and cell deformation mostly in the lateral femoral condyle cartilage 2 weeks post-surgery. Transactions of the Orthopaedic Research Society, 43: 512, 2018.

  10. Sabuhi WA, Mäkelä JTA, Snyder BD, Grinstaff MW, Characterization of a Synthetic Polymer Biolubricant in an Ex Vivo Rotational Cartilage Mechanical Model. Transactions of the Orthopaedic Research Society 43:1339, 2018.

  11. Ojanen SP, Finnilä MAJ, Saarela K, Mäkelä JTA, Herzog W, Saarakkala S, Korhonen RK, ACLT of Rabbits Alters PG Content and Cartilage Biomechanics Two Weeks Post-surgery. 15th Science day of the Campus of Kontikangas, February 2018.

  12. Ojanen S, Finnilä M, Mäkelä JTA, Saarela K, Happonen E, Herzog W, Saarakkala S, Korhonen RK. Site-specific changes of articular cartilage bioechanics and chondrocyte deformation in early OA. 23rd Congress of the European Society of Biomechancis, Seville, Spain, 2017.

  13. Mäkelä JTA, Cooper BG, Korhonen RK, Grinstaff MW, Snyder BD. Novel Interpenetrating Hydrogel Reconstitutes Articular Cartilage Mechanical Properties. Transactions of the Orthopaedic Research Society 42: 2283, 2017

  14. Nelson BB, Mäkelä JTA, Lawson TB, Snyder BD Hurtig MB, Moorman VJ, Grinstaff MW, Goodrich LR, Kawcak, CE. Cationic Contrast-Enhanced Computed Tomography Detects Subtle Equine Articular Cartilage Damage After Impact Injury and Reflects Biomechanical Properties. Transactions of the Orthopaedic Research Society 42: 1384, 2017

  15. Mäkelä JTA, Cooper BG, Grinstaff MW, Snyder BD. A unifying framework for evaluating cartilage friction and lubrication mode: Expressing the Stribeck curve as a funtion of interstitial fluid load support. Transactions of the Orthopaedic Research Society 42: 0469, 2017

  16. Drezek K, Jeyaram A, Sabuhi WA, Mäkelä JTA, Cooper BG, Snyder BD, Grinstaff MW. pMPC, a Synthetic Crosslinked Polymer Biolubricant. 43rd Northeast Bioengineering Conference (NEBEC), 2017

  17. Mäkelä JTA, Han S-K, Herzog W, Korhonen RK. Fluid flow properties of articular cartilage change most in very early osteoarthritis. Transactions of the Orthopaedic Research Society 40: 0791, 2015

  18. Danso EK, Mäkelä JA, Tanska P, Mononen ME, Honkanen JTJ, Jurvelin JS, Töyräs J, Julkunen P, Korhonen RK. Site-Specific Biomechanical Properties of Human Meniscus. Transactions of the Orthopaedic Research Society 40: 0249, 2015

  19. Mäkelä JTA, Herzog W, Korhonen RK. Collagen content is increased in lapine femoral condyle cartilage four weeks after anterior cruciate ligament transection. Transactions of the Orthopaedic Research Society 39: 1226, 2014.

  20. Florea C, Malo MKH, Rautiainen J, Mäkelä J, Nieminen M, Jurvelin JS, Davidescu A, Korhonen R, Alterations in the Properties of Rabbit Articular Cartilage and Underlying Bone at 4 weeks After Anterior Cruciate Ligament Transection.8th Combined Meeting of Orthopaedic Research Societies (CORS), Venice, Italy, 2013.

  21. Mäkelä JTA, Rezaeian ZS, Mikkonen S, Madden R, Han S-K, Jurvelin JS, Herzog W, Korhonen RK. Site-dependent changes in collagen orientation and elastic moduli in lapine articular cartilage at 4 weeks after anterior cruciate ligament transection. Transactions of the Orthopaedic Research Society 38: 1280, 2013.

  22. Mäkelä JTA, Huttu MRJ, Korhonen RK. Structure-function relationships in osteoarthritic human articular cartilage. Transactions of the Orthopaedic Research Society 37: 1800, 2012.

  23. Huttu MRJ, Puhakka J, Mäkelä JTA, Takakubo Y, Tiitu V, Saarakkala S, Konttinen YT, Kiviranta I, Korhonen RK. Relationships between cell volume, structure, composition and mechanical properties of osteoarthritic human hip articular cartilage. Transactions of the Orthopaedic Research Society 37: 1823, 2012.

Acknowledged technical contributions:

  1. Stewart RC, Honkanen JTJ, Kokkonen HT, Tiitu V, Saarakkala S, Joukainen A, Snyder BD, Jurvelin JS, Grinstaff MW, Toyras J, Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage Cartilage. 2017 Oct;8(4):391-399.

  2. Florea C, Tanska P, Mononen ME, Qu C, Lammi MJ, Laasanen MS, Korhonen RK. A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells. Biomech Model Mechanobiol. 16(1):297-311, 2017.

  3. Muhonen V, Salonius E, Haaparanta AM, Järvinen E, Paatela T, Meller A, Hannula M, Björkman M, Pyhältö T, Ellä V, Vasara A, Töyräs J, Kellomäki M, Kiviranta I, Articular cartilage repair with recombinant human type II collagen/polylactide scaffold in a preliminary porcine study. J Orthop Res. 2016 May;34(5):745-53.

Popularised articles:

  1. Mäkelä JTA, Kudosnesteen virtauksen muutokset nivelrustossa voivat ennustaa nivelrikon alkamista. Niveltieto 2/2016:11-13, Suomen nivelyhdistys ry.

  2. Elizabeth Hofheinz, Mäkelä JTA, Predict onset of OA with fluid flow, Orthopedics This Week, 21.2.2016

Contact: +358 29 4451111 (Switch), email: bbc-l [at] lists.uef.fi