Research Group

Janne Toivo August Mäkelä



Postdoctoral Research Fellow
Harvard Medical School
Beth Israel Deaconess Medical Center
Boston, Massachusetts


Biomechanics of articular cartilage

Personal information

  • Email: janne . makela [at] uef . fi (please fix the address before mailing!)
  • ResearchGate: [link]

  • Past research interests: Structure-function relationships in osteoarthritic articular cartilage.

  • Education:
    • PhD, Medical Physics, University of Eastern Finland, 2016
    • Master of Science, Medical Physics, University of Eastern Finland, 2011
    • Graduate of Finnish Upper Secondary School, Kuopion Lyseon lukio, 2001

  • Language proficiency:
    • Finnish, native language
    • English, fluent
    • Swedish, good

  • Skills: Finite element modeling (Abaqus-software); Mechanical, microscopical and spectroscopical measurements and analysis: Digital densitometry, Polarized microscopy, Fourier transform infrared imaging, Raman; Animal models; Programming languages: Matlab, Java, HTML.

Publications (Citation statistics):

(full papers, Conference proceedings [ORS])
  1. Makela JTA, Cooper BG, Korhonen RK, Grinstaff MW and Snyder BD. Functional effects of an interpenetrating polymer network on articular cartilage mechanical properties. Osteoarthritis Cartilage. 2018 Jan 8. pii: S1063-4584(18)30002-5. doi:

  2. Makela JTA and Korhonen RK. Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity. J Biomech. 2016 Jun 14;49(9):1734-1741. doi: 10.1016/j.jbiomech.2016.04.002. Epub

  3. Makela JT, Han SK, Herzog W and Korhonen RK. Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage. J Biomech. 2015 Sep 18;48(12):3369-76. doi: 10.1016/j.jbiomech.2015.06.010. Epub

  4. Puhakka PH, Te Moller NCR, Afara IO, Makela JTA, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. Osteoarthritis Cartilage. 2015 Dec;23(12):2206-2213. doi:

  5. Danso EK, Makela JT, Tanska P, Mononen ME, Honkanen JT, Jurvelin JS, Toyras J, Julkunen P and Korhonen RK. Characterization of site-specific biomechanical properties of human meniscus-Importance of collagen and fluid on mechanical nonlinearities. J Biomech. 2015 Jun 1;48(8):1499-507. doi: 10.1016/j.jbiomech.2015.01.048. Epub

  6. Florea C, Malo MK, Rautiainen J, Makela JT, Fick JM, Nieminen MT, Jurvelin JS, Davidescu A and Korhonen RK. Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2015 Mar;23(3):414-22. doi: 10.1016/j.joca.2014.11.023.

  7. Makela JT, Rezaeian ZS, Mikkonen S, Madden R, Han SK, Jurvelin JS, Herzog W and Korhonen RK. Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2014 Jun;22(6):869-78. doi: 10.1016/j.joca.2014.04.010.

  8. Huttu MR, Puhakka J, Makela JT, Takakubo Y, Tiitu V, Saarakkala S, Konttinen YT, Kiviranta I and Korhonen RK. Cell-tissue interactions in osteoarthritic human hip joint articular cartilage. Connect Tissue Res. 2014 Aug;55(4):282-91. doi: 10.3109/03008207.2014.912645.

  9. Makela JT, Huttu MR and Korhonen RK. Structure-function relationships in osteoarthritic human hip joint articular cartilage. Osteoarthritis Cartilage. 2012 Nov;20(11):1268-77. doi:

  10. Kokkonen HT, Makela J, Kulmala KA, Rieppo L, Jurvelin JS, Tiitu V, Karjalainen HM, Korhonen RK, Kovanen V and Toyras J. Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage. Osteoarthritis Cartilage. 2011 Oct;19(10):1190-8. doi:

  1. Ojanen S, Finnilä M, Mäkelä JTA, Saarela K, Happonen E, Herzog W, Saarakkala S, Korhonen RK. Site-specific changes of articular cartilage bioechanics and chondrocyte deformation in early OA. 23rd Congress of the European Society of Biomechancis, Seville, Spain, 2017.

  2. Mäkelä JTA, Cooper BG, Korhonen RK, Grinstaff MW, Snyder BD. Novel Interpenetrating Hydrogel Reconstitutes Articular Cartilage Mechanical Properties. Transactions of the Orthopaedic Research Society 42: 2283, 2017

  3. Nelson BB, Mäkelä JTA, Lawson TB, Snyder BD Hurtig MB, Moorman VJ, Grinstaff MW, Goodrich LR, Kawcak, CE. Cationic Contrast-Enhanced Computed Tomography Detects Subtle Equine Articular Cartilage Damage After Impact Injury and Reflects Biomechanical Properties. Transactions of the Orthopaedic Research Society 42: 1384, 2017

  4. Mäkelä JTA, Cooper BG, Grinstaff MW, Snyder BD. A unifying framework for evaluating cartilage friction and lubrication mode: Expressing the Stribeck curve as a funtion of interstitial fluid load support. Transactions of the Orthopaedic Research Society 42: 0469, 2017

  5. Mäkelä JTA, Han S-K, Herzog W, Korhonen RK. Fluid flow properties of articular cartilage change most in very early osteoarthritis. Transactions of the Orthopaedic Research Society 40: 0791, 2015

  6. Danso EK, Mäkelä JA, Tanska P, Mononen ME, Honkanen JTJ, Jurvelin JS, Töyräs J, Julkunen P, Korhonen RK. Site-Specific Biomechanical Properties of Human Meniscus. Transactions of the Orthopaedic Research Society 40: 0249, 2015

  7. Mäkelä JTA, Herzog W, Korhonen RK. Collagen content is increased in lapine femoral condyle cartilage four weeks after anterior cruciate ligament transection. Transactions of the Orthopaedic Research Society 39: 1226, 2014.

  8. Florea C, Malo MKH, Rautiainen J, Mäkelä J, Nieminen M, Jurvelin JS, Davidescu A, Korhonen R, Alterations in the Properties of Rabbit Articular Cartilage and Underlying Bone at 4 weeks After Anterior Cruciate Ligament Transection.8th Combined Meeting of Orthopaedic Research Societies (CORS), Venice, Italy, 2013.

  9. Mäkelä JTA, Rezaeian ZS, Mikkonen S, Madden R, Han S-K, Jurvelin JS, Herzog W, Korhonen RK. Site-dependent changes in collagen orientation and elastic moduli in lapine articular cartilage at 4 weeks after anterior cruciate ligament transection. Transactions of the Orthopaedic Research Society 38: 1280, 2013.

  10. Mäkelä JTA, Huttu MRJ, Korhonen RK. Structure-function relationships in osteoarthritic human articular cartilage. Transactions of the Orthopaedic Research Society 37: 1800, 2012.

  11. Huttu MRJ, Puhakka J, Mäkelä JTA, Takakubo Y, Tiitu V, Saarakkala S, Konttinen YT, Kiviranta I, Korhonen RK. Relationships between cell volume, structure, composition and mechanical properties of osteoarthritic human hip articular cartilage. Transactions of the Orthopaedic Research Society 37: 1823, 2012.

Contact: +358 20 7872211 (Switch), email: bbc-l [at] lists.uef.fi