Group overview

Personal profiles

Group leaders

Post Doc researchers

Ph.D. Students

Laboratory engineer

Active Collaborators

Emeritus and Emerita members

Research Group

Juha's group

Group leader

Academy research fellow

Adjunct professor

Post Doc researchers

Ph.D. students

Minna Husso
Laura Kalevo
Samu Kainulainen
Henri Korkalainen
Akseli Leino
Tomi Miettinen
Sami Nikkonen
Nikae te Moller (Utrecht University)
Tytti Niemelä (University of Helsinki)
Brett Duce (Queensland University of Technology)

Recent publications

  • Afara IO, Florea C, Olumegbon IA, Eneh CT, Malo MKH, Korhonen RK and Toyras J. Characterizing human subchondral bone properties using near-infrared (NIR) spectroscopy. Sci Rep. 2018 Jun 27;8(1):9733. doi: 10.1038/s41598-018-27786-3.

  • Nykanen O, Rieppo L, Toyras J, Kolehmainen V, Saarakkala S, Shmueli K and Nissi MJ. Quantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments. Magn Reson Med. 2018 Dec;80(6):2702-2716. doi: 10.1002/mrm.27216. Epub 2018 Apr 24.

  • Joukainen A, Viren T, Penttila P, Liukkonen J, Puhakka PH, Kroger H and Toyras J. Ultrasound Arthroscopy of Hip in Treatment of Osteochondritis Dissecans. Arthrosc Tech. 2017 Jul 17;6(4):e1063-e1068. doi: 10.1016/j.eats.2017.03.022. eCollection 2017 Aug.

  • Sarin JK, Brommer H, Arguelles D, Puhakka PH, Inkinen SI, Afara IO, Saarakkala S and Toyras J. Corrigendum to "Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo" [Osteoarthritis Cartilage 25 (5) (2017 May) 790-798]. Osteoarthritis Cartilage. 2017 Aug;25(8):1377-1378. doi: 10.1016/j.joca.2017.05.010. Epub 2017 May 27.

  • Eneh CT, Afara IO, Malo MK, Jurvelin JS and Toyras J. Porosity predicted from ultrasound backscatter using multivariate analysis can improve accuracy of cortical bone thickness assessment. J Acoust Soc Am. 2017 Jan;141(1):575. doi: 10.1121/1.4973572.

  • Sarin JK, Brommer H, Arguelles D, Puhakka PH, Inkinen SI, Afara IO, Saarakkala S and Toyras J. Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo. Osteoarthritis Cartilage. 2017 May;25(5):790-798. doi: 10.1016/j.joca.2016.12.007. Epub 2016 Dec 10.

  • Te Moller NCR, Pitkanen M, Sarin JK, Vaananen S, Liukkonen J, Afara IO, Puhakka PH, Brommer H, Niemela T, Tulamo RM, Arguelles Capilla D and Toyras J. Semi-automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images. Equine Vet J. 2017 Jul;49(4):552-555. doi: 10.1111/evj.12637. Epub 2016 Oct 20.

  • Inkinen SI, Liukkonen J, Malo MK, Viren T, Jurvelin JS and Toyras J. Finite difference time domain model of ultrasound propagation in agarose scaffold containing collagen or chondrocytes. J Acoust Soc Am. 2016 Jul;140(1):1. doi: 10.1121/1.4953021.

  • Linder H, Malo MK, Liukkonen J, Jurvelin JS and Toyras J. Phased-array ultrasound technology enhances accuracy of dual frequency ultrasound measurements - towards improved ultrasound bone diagnostics. J Med Eng Technol. 2016 Aug;40(6):293-7. doi: 10.1080/03091902.2016.1185472. Epub 2016 May 17.

  • Puhakka PH, Te Moller NC, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound. Acta Orthop. 2016 Aug;87(4):418-24. doi: 10.1080/17453674.2016.1180578. Epub 2016 May 10.

  • Eneh CT, Malo MK, Karjalainen JP, Liukkonen J, Toyras J and Jurvelin JS. Effect of porosity, tissue density, and mechanical properties on radial sound speed in human cortical bone. Med Phys. 2016 May;43(5):2030. doi: 10.1118/1.4942808.

  • Rautiainen J, Nieminen MT, Salo EN, Kokkonen HT, Mangia S, Michaeli S, Grohn O, Jurvelin JS, Toyras J and Nissi MJ. Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage. Osteoarthritis Cartilage. 2016 Sep;24(9):1656-64. doi: 10.1016/j.joca.2016.04.017. Epub 2016 Apr 30.

  • Mannicke N, Schone M, Liukkonen J, Fachet D, Inkinen S, Malo MK, Oelze ML, Toyras J, Jurvelin JS and Raum K. Species-Independent Modeling of High-Frequency Ultrasound Backscatter in Hyaline Cartilage. Ultrasound Med Biol. 2016 Jun;42(6):1375-84. doi: 10.1016/j.ultrasmedbio.2016.01.018. Epub 2016 Mar 31.

  • Eneh CT, Liukkonen J, Malo MK, Jurvelin JS and Toyras J. Inter-individual changes in cortical bone three-dimensional microstructure and elastic coefficient have opposite effects on radial sound speed. J Acoust Soc Am. 2015 Dec;138(6):3491-9. doi: 10.1121/1.4934276.

  • Penttila P, Liukkonen J, Joukainen A, Viren T, Jurvelin JS, Toyras J and Kroger H. Diagnosis of Knee Osteochondral Lesions With Ultrasound Imaging. Arthrosc Tech. 2015 Sep 14;4(5):e429-33. doi: 10.1016/j.eats.2015.04.002. eCollection 2015 Oct.

  • Puhakka PH, Te Moller NCR, Afara IO, Makela JTA, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. Osteoarthritis Cartilage. 2015 Dec;23(12):2206-2213. doi: 10.1016/j.joca.2015.05.034. Epub 2015 Jun 6.

  • Inkinen SI, Liukkonen J, Tiitu V, Viren T, Jurvelin JS and Toyras J. Ultrasound Backscattering Is Anisotropic in Bovine Articular Cartilage. Ultrasound Med Biol. 2015 Jul;41(7):1958-66. doi: 10.1016/j.ultrasmedbio.2015.03.021. Epub 2015 Apr 29.

  • Puhakka PH, Ylarinne JH, Lammi MJ, Saarakkala S, Tiitu V, Kroger H, Viren T, Jurvelin JS and Toyras J. Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds. Phys Med Biol. 2014 Nov 7;59(21):6537-48. doi: 10.1088/0031-9155/59/21/6537. Epub 2014 Oct 13.

  • Liukkonen J, Lehenkari P, Hirvasniemi J, Joukainen A, Viren T, Saarakkala S, Nieminen MT, Jurvelin JS and Toyras J. Ultrasound arthroscopy of human knee cartilage and subchondral bone in vivo. Ultrasound Med Biol. 2014 Sep;40(9):2039-47. doi: 10.1016/j.ultrasmedbio.2014.04.001. Epub 2014 Jul 9.

  • Inkinen S, Liukkonen J, Ylarinne JH, Puhakka PH, Lammi MJ, Viren T, Jurvelin JS and Toyras J. Collagen and chondrocyte concentrations control ultrasound scattering in agarose scaffolds. Ultrasound Med Biol. 2014 Sep;40(9):2162-71. doi: 10.1016/j.ultrasmedbio.2014.03.016. Epub 2014 Jun 25.

  • Niemela T, Viren T, Liukkonen J, Arguelles D, te Moller NC, Puhakka PH, Jurvelin JS, Tulamo RM and Toyras J. Application of optical coherence tomography enhances reproducibility of arthroscopic evaluation of equine joints. Acta Vet Scand. 2014 Jan 10;56:3. doi: 10.1186/1751-0147-56-3.

  • te Moller NC, Brommer H, Liukkonen J, Viren T, Timonen M, Puhakka PH, Jurvelin JS, van Weeren PR and Toyras J. Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses. Vet J. 2013 Sep;197(3):589-95. doi: 10.1016/j.tvjl.2013.05.031. Epub 2013 Jun 28.

  • Liukkonen J, Hirvasniemi J, Joukainen A, Penttila P, Viren T, Saarakkala S, Kroger H, Jurvelin JS and Toyras J. Arthroscopic ultrasound technique for simultaneous quantitative assessment of articular cartilage and subchondral bone: an in vitro and in vivo feasibility study. Ultrasound Med Biol. 2013 Aug;39(8):1460-8. doi: 10.1016/j.ultrasmedbio.2013.03.026. Epub 2013 Jun 4.

  • Salo EN, Nissi MJ, Kulmala KA, Tiitu V, Toyras J and Nieminen MT. Diffusion of Gd-DTPA(2)(-) into articular cartilage. Osteoarthritis Cartilage. 2012 Feb;20(2):117-26. doi: 10.1016/j.joca.2011.11.016. Epub 2011 Dec 2.

  • Kaleva E, Liukkonen J, Toyras J, Saarakkala S, Kiviranta P and Jurvelin J. 2-D finite difference time domain model of ultrasound reflection from normal and osteoarthritic human articular cartilage surface. IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Apr;57(4):892-9. doi: 10.1109/TUFFC.2010.1493.

  • Kurkijarvi JE, Nissi MJ, Rieppo J, Toyras J, Kiviranta I, Nieminen MT and Jurvelin JS. The zonal architecture of human articular cartilage described by T2 relaxation time in the presence of Gd-DTPA2-. Magn Reson Imaging. 2008 Jun;26(5):602-7. doi: 10.1016/j.mri.2007.10.013. Epub 2007 Dec 26.

  • Nissi MJ, Rieppo J, Toyras J, Laasanen MS, Kiviranta I, Nieminen MT and Jurvelin JS. Estimation of mechanical properties of articular cartilage with MRI - dGEMRIC, T2 and T1 imaging in different species with variable stages of maturation. Osteoarthritis Cartilage. 2007 Oct;15(10):1141-8. doi: 10.1016/j.joca.2007.03.018. Epub 2007 May 21.

  • Kiviranta P, Toyras J, Nieminen MT, Laasanen MS, Saarakkala S, Nieminen HJ, Nissi MJ and Jurvelin JS. Comparison of novel clinically applicable methodology for sensitive diagnostics of cartilage degeneration. Eur Cell Mater. 2007 Apr 3;13:46-55; discussion 55.

  • Nissi MJ, Rieppo J, Toyras J, Laasanen MS, Kiviranta I, Jurvelin JS and Nieminen MT. T(2) relaxation time mapping reveals age- and species-related diversity of collagen network architecture in articular cartilage. Osteoarthritis Cartilage. 2006 Dec;14(12):1265-71. doi: 10.1016/j.joca.2006.06.002. Epub 2006 Jul 14.

  • Nissi MJ, Toyras J, Laasanen MS, Rieppo J, Saarakkala S, Lappalainen R, Jurvelin JS and Nieminen MT. Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage. J Orthop Res. 2004 May;22(3):557-64. doi: 10.1016/j.orthres.2003.09.008.

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