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Laboratory engineer

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Research Group

Jukka Sakari Jurvelin

Ph.D., Professor, Co-head of the BBC group

Personal information

  • Phone: +358 17 162530
  • Cellular: +358 40 5148507
  • Room: Me/232
  • Email: jukka.jurvelin [at] uef.fi (please fix the address before mailing!)

  • Present position: Professor of Medical Physics and Engineering, Department of Applied Physics, University of Eastern Finland, Kuopio, Finland

  • Current research interests: Biomechanics of soft and hard tissues, Bone Mineral Analysis, Biological Ultrasound, Electron Microscopy, Atomic Force Microscopy, Stereology, Nuclear Medicine Imaging, Magnetic Resonance Imaging, Finite Element Modeling, Physiological measurements and instrumentation, Quality Control

  • Current research interests: Research Associate, Department of Anatomy, University of Kuopio; Kuopio, Finland, 1983-1986; Associate Physicist, Department of Radiotherapy, Kuopio University; Hospital, Kuopio, Finland, 1988-1989; Associate Physicist, Department of Clinical Physiology, Kuopio; University Hospital, Kuopio, Finland, 1990-1991; Senior Physicist, Department of Clinical Physiology, Kuopio University; Hospital, Kuopio, Finland, 1992-2/2001; Associate Head Physicist, Department of Clinical Physiology and Nuclear medicine, Kuopio University Hospital, Kuopio, Finland, 3/2001-

  • Education:
    • Academic:
      • M. Sc. (Medical Physics), University of Kuopio, Kuopio, Finland, 1982
      • Ph. D. (Medical Physics), University of Kuopio, Kuopio, Finland, 1993
      • Docent (Biophysics), University of Kuopio, Kuopio, Finland, 1996
    • Professional:
      • Specialty of Senior Hospital Physicist, Ministry of Social Health, Finland, 1991.
    • Scientific:
      • Postdoctoral fellow, ME Müller Institute for Biomechanics, University Bern, Bern, Switzerland, 1.9.1993-31.8.1995.

  • Language proficiency
    • Finnish, native language
    • English, good
    • Swedish, fairly good
    • German, fairly good

  • Membership in scientific and professional organizations
    • Member, Editorial Consultant´s Panel, Journal of Biomechanics
    • Member, Editorial Board, Osteoarthritis & Cartilage
    • Member, OsteoArthritis Research Society International (OARSI)
    • Member, The Finnish Association of Isotope Medicine
    • Member, Association of Hospital Physicists in Finland

Publications:

The recent 200 publications
  1. Myller KAH, Korhonen R, Toyras J, Tanska P, Vaananen S, Jurvelin JS, Saarakkala S and Mononen ME. Clinical Contrast-enhanced Computed Tomography with Semiautomatic Segmentation Provides Feasible Input for Computational Models of the Knee Joint. J Biomech Eng. 2019 Oct 1. pii: 1066004. doi: 10.1115/1.4045279.

  2. Vaananen SP, Grassi L, Venalainen MS, Matikka H, Zheng Y, Jurvelin JS and Isaksson H. Automated segmentation of cortical and trabecular bone to generate finite element models for femoral bone mechanics. Med Eng Phys. 2019 Aug;70:19-28. doi: 10.1016/j.medengphy.2019.06.015.

  3. Grassi L, Vaananen SP, Ristinmaa M, Jurvelin JS and Isaksson H. Correction to: Prediction of femoral strength using 3D finite element models reconstructed from DXA images: validation against experiments. Biomech Model Mechanobiol. 2019 Aug;18(4):1263-1267. doi: 10.1007/s10237-019-01173-x.

  4. Saukko AEA, Turunen MJ, Honkanen MKM, Lovric G, Tiitu V, Honkanen JTJ, Grinstaff MW, Jurvelin JS and Toyras J. Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging. Sci Rep. 2019 May 8;9(1):7118. doi: 10.1038/s41598-019-43276-6.

  5. Venalainen MS, Mononen ME, Salo J, Rasanen LP, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Publisher Correction: Quantitative Evaluation of the Mechanical Risks Caused by Focal Cartilage Defects in the Knee. Sci Rep. 2019 Apr 4;9(1):5660. doi: 10.1038/s41598-019-41384-x.

  6. Myller KAH, Korhonen RK, Toyras J, Salo J, Jurvelin JS and Venalainen MS. Computational evaluation of altered biomechanics related to articular cartilage lesions observed in vivo. J Orthop Res. 2019 May;37(5):1042-1051. doi: 10.1002/jor.24273.

  7. Honkanen MKM, Matikka H, Honkanen JTJ, Bhattarai A, Grinstaff MW, Joukainen A, Kroger H, Jurvelin JS and Toyras J. Imaging of proteoglycan and water contents in human articular cartilage with full-body CT using dual contrast technique. J Orthop Res. 2019 May;37(5):1059-1070. doi: 10.1002/jor.24256.

  8. Grassi L, Vaananen SP, Ristinmaa M, Jurvelin JS and Isaksson H. Corrigendum to "How accurately can subject-specific finite element models predict strains and strength of human femora? Investigation using full-field measurements" [J. Biomech. 49 (2016) 802-806]. J Biomech. 2019 Feb 14;84:290-292. doi: 10.1016/j.jbiomech.2018.12.032.

  9. Bolcos PO, Mononen ME, Mohammadi A, Ebrahimi M, Tanaka MS, Samaan MA, Souza RB, Li X, Suomalainen JS, Jurvelin JS, Toyras J and Korhonen RK. Comparison between kinetic and kinetic-kinematic driven knee joint finite element models. Sci Rep. 2018 Nov 26;8(1):17351. doi: 10.1038/s41598-018-35628-5.

  10. Myller KAH, Honkanen JTJ, Jurvelin JS, Saarakkala S, Toyras J and Vaananen SP. Method for Segmentation of Knee Articular Cartilages Based on Contrast-Enhanced CT Images. Ann Biomed Eng. 2018 Nov;46(11):1756-1767. doi: 10.1007/s10439-018-2081-z.

  11. Pouran B, Arbabi V, Bajpayee AG, van Tiel J, Toyras J, Jurvelin JS, Malda J, Zadpoor AA and Weinans H. Multi-scale imaging techniques to investigate solute transport across articular cartilage. J Biomech. 2018 Sep 10;78:10-20. doi: 10.1016/j.jbiomech.2018.06.012.

  12. Bhattarai A, Honkanen JTJ, Myller KAH, Prakash M, Korhonen M, Saukko AEA, Viren T, Joukainen A, Patwa AN, Kroger H, Grinstaff MW, Jurvelin JS and Toyras J. Quantitative Dual Contrast CT Technique for Evaluation of Articular Cartilage Properties. Ann Biomed Eng. 2018 Jul;46(7):1038-1046. doi: 10.1007/s10439-018-2013-y.

  13. Svard T, Lakovaara M, Pakarinen H, Haapea M, Kiviranta I, Lammentausta E, Jurvelin J, Tervonen O, Ojala R and Nieminen M. Quantitative MRI of Human Cartilage In Vivo: Relationships with Arthroscopic Indentation Stiffness and Defect Severity. Cartilage. 2018 Jan;9(1):46-54. doi: 10.1177/1947603516684592.

  14. Ojanen X, Tanska P, Malo MKH, Isaksson H, Vaananen SP, Koistinen AP, Grassi L, Magnusson SP, Ribel-Madsen SM, Korhonen RK, Jurvelin JS and Toyras J. Tissue viscoelasticity is related to tissue composition but may not fully predict the apparent-level viscoelasticity in human trabecular bone - An experimental and finite element study. J Biomech. 2017 Dec 8;65:96-105. doi: 10.1016/j.jbiomech.2017.10.002.

  15. Stewart RC, Honkanen JTJ, Kokkonen HT, Tiitu V, Saarakkala S, Joukainen A, Snyder BD, Jurvelin JS, Grinstaff MW and Toyras J. Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage. Cartilage. 2017 Oct;8(4):391-399. doi: 10.1177/1947603516665443.

  16. Saukko AEA, Honkanen JTJ, Xu W, Vaananen SP, Jurvelin JS, Lehto VP and Toyras J. Dual Contrast CT Method Enables Diagnostics of Cartilage Injuries and Degeneration Using a Single CT Image. Ann Biomed Eng. 2017 Dec;45(12):2857-2866. doi: 10.1007/s10439-017-1916-3.

  17. Tong X, Malo MKH, Burton IS, Jurvelin JS, Isaksson H and Kroger H. Histomorphometric and osteocytic characteristics of cortical bone in male subtrochanteric femoral shaft. J Anat. 2017 Nov;231(5):708-717. doi: 10.1111/joa.12670.

  18. Tong X, Burton IS, Jurvelin JS, Isaksson H and Kroger H. Iliac crest histomorphometry and skeletal heterogeneity in men. Bone Rep. 2016 Nov 28;6:9-16. doi: 10.1016/j.bonr.2016.11.004. eCollection 2017 Jun.

  19. Eneh CT, Afara IO, Malo MK, Jurvelin JS and Toyras J. Porosity predicted from ultrasound backscatter using multivariate analysis can improve accuracy of cortical bone thickness assessment. J Acoust Soc Am. 2017 Jan;141(1):575. doi: 10.1121/1.4973572.

  20. Grassi L, Vaananen SP, Ristinmaa M, Jurvelin JS and Isaksson H. Prediction of femoral strength using 3D finite element models reconstructed from DXA images: validation against experiments. Biomech Model Mechanobiol. 2017 Jun;16(3):989-1000. doi: 10.1007/s10237-016-0866-2.

  21. Ojanen X, Toyras J, Inkinen SI, Malo MK, Isaksson H and Jurvelin JS. Differences in acoustic impedance of fresh and embedded human trabecular bone samples-Scanning acoustic microscopy and numerical evaluation. J Acoust Soc Am. 2016 Sep;140(3):1931. doi: 10.1121/1.4962347.

  22. Venalainen MS, Mononen ME, Salo J, Rasanen LP, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Quantitative Evaluation of the Mechanical Risks Caused by Focal Cartilage Defects in the Knee. Sci Rep. 2016 Nov 29;6:37538. doi: 10.1038/srep37538.

  23. Kokkonen HT, Chin HC, Toyras J, Jurvelin JS and Quinn TM. Solute Transport of Negatively Charged Contrast Agents Across Articular Surface of Injured Cartilage. Ann Biomed Eng. 2017 Apr;45(4):973-981. doi: 10.1007/s10439-016-1756-6.

  24. Rasanen LP, Tanska P, Mononen ME, Lammentausta E, Zbyn S, Venalainen MS, Szomolanyi P, van Donkelaar CC, Jurvelin JS, Trattnig S, Nieminen MT and Korhonen RK. Spatial variation of fixed charge density in knee joint cartilage from sodium MRI - Implication on knee joint mechanics under static loading. J Biomech. 2016 Oct 3;49(14):3387-3396. doi: 10.1016/j.jbiomech.2016.09.011.

  25. Myller KA, Turunen MJ, Honkanen JT, Vaananen SP, Iivarinen JT, Salo J, Jurvelin JS and Toyras J. In Vivo Contrast-Enhanced Cone Beam CT Provides Quantitative Information on Articular Cartilage and Subchondral Bone. Ann Biomed Eng. 2017 Mar;45(3):811-818. doi: 10.1007/s10439-016-1730-3.

  26. Saarelainen J, Hakulinen M, Rikkonen T, Kroger H, Koivumaa-Honkanen H, Honkanen R and Jurvelin JS. Inclusion of Regional Body Composition Parameters Improves Bone Mineral Density Cross-Calibration Between GE Lunar Prodigy and iDXA Densitometers. J Clin Densitom. 2017 Jan - Mar;20(1):97-105. doi: 10.1016/j.jocd.2016.07.006.

  27. Inkinen SI, Liukkonen J, Malo MK, Viren T, Jurvelin JS and Toyras J. Finite difference time domain model of ultrasound propagation in agarose scaffold containing collagen or chondrocytes. J Acoust Soc Am. 2016 Jul;140(1):1. doi: 10.1121/1.4953021.

  28. Turunen MJ, Kaspersen JD, Olsson U, Guizar-Sicairos M, Bech M, Schaff F, Tagil M, Jurvelin JS and Isaksson H. Bone mineral crystal size and organization vary across mature rat bone cortex. J Struct Biol. 2016 Sep;195(3):337-344. doi: 10.1016/j.jsb.2016.07.005.

  29. Puhakka J, Afara IO, Paatela T, Sormaala MJ, Timonen MA, Viren T, Jurvelin JS, Toyras J and Kiviranta I. In Vivo Evaluation of the Potential of High-Frequency Ultrasound for Arthroscopic Examination of the Shoulder Joint. Cartilage. 2016 Jul;7(3):248-55. doi: 10.1177/1947603515617280.

  30. Saarelainen J, Hakulinen M, Rikkonen T, Kroger H, Tuppurainen M, Koivumaa-Honkanen H, Honkanen R, Hujo M and Jurvelin JS. Cross-Calibration of GE Healthcare Lunar Prodigy and iDXA Dual-Energy X-Ray Densitometers for Bone Mineral Measurements. J Osteoporos. 2016;2016:1424582. doi: 10.1155/2016/1424582.

  31. Linder H, Malo MK, Liukkonen J, Jurvelin JS and Toyras J. Phased-array ultrasound technology enhances accuracy of dual frequency ultrasound measurements - towards improved ultrasound bone diagnostics. J Med Eng Technol. 2016 Aug;40(6):293-7. doi: 10.1080/03091902.2016.1185472.

  32. Puhakka PH, Te Moller NC, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound. Acta Orthop. 2016 Aug;87(4):418-24. doi: 10.1080/17453674.2016.1180578.

  33. Eneh CT, Malo MK, Karjalainen JP, Liukkonen J, Toyras J and Jurvelin JS. Effect of porosity, tissue density, and mechanical properties on radial sound speed in human cortical bone. Med Phys. 2016 May;43(5):2030. doi: 10.1118/1.4942808.

  34. Rautiainen J, Nieminen MT, Salo EN, Kokkonen HT, Mangia S, Michaeli S, Grohn O, Jurvelin JS, Toyras J and Nissi MJ. Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage. Osteoarthritis Cartilage. 2016 Sep;24(9):1656-64. doi: 10.1016/j.joca.2016.04.017.

  35. Halonen KS, Mononen ME, Jurvelin JS, Toyras J, Klodowski A, Kulmala JP and Korhonen RK. Importance of Patella, Quadriceps Forces, and Depthwise Cartilage Structure on Knee Joint Motion and Cartilage Response During Gait. J Biomech Eng. 2016 Jul 1;138(7). pii: 2520868. doi: 10.1115/1.4033516.

  36. Honkanen JTJ, Turunen MJ, Freedman JD, Saarakkala S, Grinstaff MW, Ylarinne JH, Jurvelin JS and Toyras J. Cationic Contrast Agent Diffusion Differs Between Cartilage and Meniscus. Ann Biomed Eng. 2016 Oct;44(10):2913-2921. doi: 10.1007/s10439-016-1629-z.

  37. Dahlberg LE, Aydemir A, Muurahainen N, Guhring H, Fredberg Edebo H, Krarup-Jensen N, Ladel CH and Jurvelin JS. A first-in-human, double-blind, randomised, placebo-controlled, dose ascending study of intra-articular rhFGF18 (sprifermin) in patients with advanced knee osteoarthritis. Clin Exp Rheumatol. 2016 May-Jun;34(3):445-50.

  38. Mannicke N, Schone M, Liukkonen J, Fachet D, Inkinen S, Malo MK, Oelze ML, Toyras J, Jurvelin JS and Raum K. Species-Independent Modeling of High-Frequency Ultrasound Backscatter in Hyaline Cartilage. Ultrasound Med Biol. 2016 Jun;42(6):1375-84. doi: 10.1016/j.ultrasmedbio.2016.01.018.

  39. Venalainen MS, Mononen ME, Vaananen SP, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Effect of bone inhomogeneity on tibiofemoral contact mechanics during physiological loading. J Biomech. 2016 May 3;49(7):1111-1120. doi: 10.1016/j.jbiomech.2016.02.033.

  40. Grassi L, Vaananen SP, Ristinmaa M, Jurvelin JS and Isaksson H. How accurately can subject-specific finite element models predict strains and strength of human femora? Investigation using full-field measurements. J Biomech. 2016 Mar 21;49(5):802-806. doi: 10.1016/j.jbiomech.2016.02.032.

  41. Eneh CT, Liukkonen J, Malo MK, Jurvelin JS and Toyras J. Inter-individual changes in cortical bone three-dimensional microstructure and elastic coefficient have opposite effects on radial sound speed. J Acoust Soc Am. 2015 Dec;138(6):3491-9. doi: 10.1121/1.4934276.

  42. Rasanen LP, Mononen ME, Lammentausta E, Nieminen MT, Jurvelin JS and Korhonen RK. Three dimensional patient-specific collagen architecture modulates cartilage responses in the knee joint during gait. Comput Methods Biomech Biomed Engin. 2016;19(11):1225-40. doi: 10.1080/10255842.2015.1124269.

  43. Penttila P, Liukkonen J, Joukainen A, Viren T, Jurvelin JS, Toyras J and Kroger H. Diagnosis of Knee Osteochondral Lesions With Ultrasound Imaging. Arthrosc Tech. 2015 Sep 14;4(5):e429-33. doi: 10.1016/j.eats.2015.04.002. eCollection 2015 Oct.

  44. Honkanen JT, Turunen MJ, Tiitu V, Jurvelin JS and Toyras J. Transport of Iodine Is Different in Cartilage and Meniscus. Ann Biomed Eng. 2016 Jul;44(7):2114-22. doi: 10.1007/s10439-015-1513-2.

  45. Karjalainen JP, Riekkinen O, Toyras J, Jurvelin JS and Kroger H. New method for point-of-care osteoporosis screening and diagnostics. Osteoporos Int. 2016 Mar;27(3):971-977. doi: 10.1007/s00198-015-3387-4.

  46. Iivarinen JT, Korhonen RK and Jurvelin JS. Modeling of interstitial fluid movement in soft tissue under negative pressure--relevance to treatment of tissue swelling. Comput Methods Biomech Biomed Engin. 2016;19(10):1089-98. doi: 10.1080/10255842.2015.1101073.

  47. Afara IO, Hauta-Kasari M, Jurvelin JS, Oloyede A and Toyras J. Optical absorption spectra of human articular cartilage correlate with biomechanical properties, histological score and biochemical composition. Physiol Meas. 2015 Sep;36(9):1913-28. doi: 10.1088/0967-3334/36/9/1913.

  48. Ryd L, Brittberg M, Eriksson K, Jurvelin JS, Lindahl A, Marlovits S, Moller P, Richardson JB, Steinwachs M and Zenobi-Wong M. Pre-Osteoarthritis: Definition and Diagnosis of an Elusive Clinical Entity. Cartilage. 2015 Jul;6(3):156-65. doi: 10.1177/1947603515586048.

  49. Vaananen SP, Grassi L, Flivik G, Jurvelin JS and Isaksson H. Generation of 3D shape, density, cortical thickness and finite element mesh of proximal femur from a DXA image. Med Image Anal. 2015 Aug;24(1):125-134. doi: 10.1016/j.media.2015.06.001.

  50. Puhakka PH, Te Moller NCR, Afara IO, Makela JTA, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. Osteoarthritis Cartilage. 2015 Dec;23(12):2206-2213. doi: 10.1016/j.joca.2015.05.034.

  51. Turunen MJ, Toyras J, Kokkonen HT and Jurvelin JS. Quantitative evaluation of knee subchondral bone mineral density using cone beam computed tomography. IEEE Trans Med Imaging. 2015 Oct;34(10):2186-90. doi: 10.1109/TMI.2015.2426684.

  52. Inkinen SI, Liukkonen J, Tiitu V, Viren T, Jurvelin JS and Toyras J. Ultrasound Backscattering Is Anisotropic in Bovine Articular Cartilage. Ultrasound Med Biol. 2015 Jul;41(7):1958-66. doi: 10.1016/j.ultrasmedbio.2015.03.021.

  53. Honkanen JT, Danso EK, Suomalainen JS, Tiitu V, Korhonen RK, Jurvelin JS and Toyras J. Contrast enhanced imaging of human meniscus using cone beam CT. Osteoarthritis Cartilage. 2015 Aug;23(8):1367-76. doi: 10.1016/j.joca.2015.03.037.

  54. Arokoski ME, Tiitu V, Jurvelin JS, Korhonen RK and Fick JM. Topographical investigation of changes in depth-wise proteoglycan distribution in rabbit femoral articular cartilage at 4 weeks after transection of the anterior cruciate ligament. J Orthop Res. 2015 Sep;33(9):1278-86. doi: 10.1002/jor.22906.

  55. Danso EK, Makela JT, Tanska P, Mononen ME, Honkanen JT, Jurvelin JS, Toyras J, Julkunen P and Korhonen RK. Characterization of site-specific biomechanical properties of human meniscus-Importance of collagen and fluid on mechanical nonlinearities. J Biomech. 2015 Jun 1;48(8):1499-507. doi: 10.1016/j.jbiomech.2015.01.048.

  56. Tong X, Burton IS, Isaksson H, Jurvelin JS and Kroger H. Cortical bone histomorphometry in male femoral neck: the investigation of age-association and regional differences. Calcif Tissue Int. 2015 Apr;96(4):295-306. doi: 10.1007/s00223-015-9957-9.

  57. Ojanen X, Isaksson H, Toyras J, Turunen MJ, Malo MK, Halvari A and Jurvelin JS. Relationships between tissue composition and viscoelastic properties in human trabecular bone. J Biomech. 2015 Jan 21;48(2):269-75. doi: 10.1016/j.jbiomech.2014.11.034.

  58. Florea C, Malo MK, Rautiainen J, Makela JT, Fick JM, Nieminen MT, Jurvelin JS, Davidescu A and Korhonen RK. Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2015 Mar;23(3):414-22. doi: 10.1016/j.joca.2014.11.023.

  59. Venalainen MS, Mononen ME, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Importance of material properties and porosity of bone on mechanical response of articular cartilage in human knee joint--a two-dimensional finite element study. J Biomech Eng. 2014 Dec;136(12):121005. doi: 10.1115/1.4028801.

  60. Puhakka PH, Ylarinne JH, Lammi MJ, Saarakkala S, Tiitu V, Kroger H, Viren T, Jurvelin JS and Toyras J. Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds. Phys Med Biol. 2014 Nov 7;59(21):6537-48. doi: 10.1088/0031-9155/59/21/6537.

  61. Grassi L, Vaananen SP, Yavari SA, Jurvelin JS, Weinans H, Ristinmaa M, Zadpoor AA and Isaksson H. Full-field strain measurement during mechanical testing of the human femur at physiologically relevant strain rates. J Biomech Eng. 2014 Nov;136(11). pii: 1901145. doi: 10.1115/1.4028415.

  62. Liukkonen J, Lehenkari P, Hirvasniemi J, Joukainen A, Viren T, Saarakkala S, Nieminen MT, Jurvelin JS and Toyras J. Ultrasound arthroscopy of human knee cartilage and subchondral bone in vivo. Ultrasound Med Biol. 2014 Sep;40(9):2039-47. doi: 10.1016/j.ultrasmedbio.2014.04.001.

  63. Inkinen S, Liukkonen J, Ylarinne JH, Puhakka PH, Lammi MJ, Viren T, Jurvelin JS and Toyras J. Collagen and chondrocyte concentrations control ultrasound scattering in agarose scaffolds. Ultrasound Med Biol. 2014 Sep;40(9):2162-71. doi: 10.1016/j.ultrasmedbio.2014.03.016.

  64. Halonen KS, Mononen ME, Jurvelin JS, Toyras J, Salo J and Korhonen RK. Deformation of articular cartilage during static loading of a knee joint--experimental and finite element analysis. J Biomech. 2014 Jul 18;47(10):2467-74. doi: 10.1016/j.jbiomech.2014.04.013.

  65. Malo MK, Toyras J, Karjalainen JP, Isaksson H, Riekkinen O and Jurvelin JS. Ultrasound backscatter measurements of intact human proximal femurs--relationships of ultrasound parameters with tissue structure and mineral density. Bone. 2014 Jul;64:240-5. doi: 10.1016/j.bone.2014.04.014.

  66. Makela JT, Rezaeian ZS, Mikkonen S, Madden R, Han SK, Jurvelin JS, Herzog W and Korhonen RK. Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2014 Jun;22(6):869-78. doi: 10.1016/j.joca.2014.04.010.

  67. Qu C, Hirviniemi M, Tiitu V, Jurvelin JS, Toyras J and Lammi MJ. Effects of Freeze-Thaw Cycle with and without Proteolysis Inhibitors and Cryopreservant on the Biochemical and Biomechanical Properties of Articular Cartilage. Cartilage. 2014 Apr;5(2):97-106. doi: 10.1177/1947603513515998.

  68. Tong XY, Malo M, Tamminen IS, Isaksson H, Jurvelin JS and Kroger H. Development of new criteria for cortical bone histomorphometry in femoral neck: intra- and inter-observer reproducibility. J Bone Miner Metab. 2015 Jan;33(1):109-18. doi: 10.1007/s00774-014-0562-1.

  69. Rieppo L, Saarakkala S, Jurvelin JS and Rieppo J. Optimal variable selection for Fourier transform infrared spectroscopic analysis of articular cartilage composition. J Biomed Opt. 2014 Feb;19(2):027003. doi: 10.1117/1.JBO.19.2.027003.

  70. Turunen MJ, Lages S, Labrador A, Olsson U, Tagil M, Jurvelin JS and Isaksson H. Evaluation of composition and mineral structure of callus tissue in rat femoral fracture. J Biomed Opt. 2014 Feb;19(2):025003. doi: 10.1117/1.JBO.19.2.025003.

  71. Koistinen AP, Halmesmaki EP, Iivarinen JT, Arokoski JP, Brama PA, Jurvelin JS, Helminen HJ and Isaksson H. Short-term exercise-induced improvements in bone properties are for the most part not maintained during aging in hamsters. Exp Gerontol. 2014 Mar;51:46-53. doi: 10.1016/j.exger.2013.12.017.

  72. Niemela T, Viren T, Liukkonen J, Arguelles D, te Moller NC, Puhakka PH, Jurvelin JS, Tulamo RM and Toyras J. Application of optical coherence tomography enhances reproducibility of arthroscopic evaluation of equine joints. Acta Vet Scand. 2014 Jan 10;56:3. doi: 10.1186/1751-0147-56-3.

  73. Iivarinen JT, Korhonen RK and Jurvelin JS. Experimental and numerical analysis of soft tissue stiffness measurement using manual indentation device--significance of indentation geometry and soft tissue thickness. Skin Res Technol. 2014 Aug;20(3):347-54. doi: 10.1111/srt.12125.

  74. Kokkonen HT, Suomalainen JS, Joukainen A, Kroger H, Sirola J, Jurvelin JS, Salo J and Toyras J. In vivo diagnostics of human knee cartilage lesions using delayed CBCT arthrography. J Orthop Res. 2014 Mar;32(3):403-12. doi: 10.1002/jor.22521.

  75. Rieppo L, Narhi T, Helminen HJ, Jurvelin JS, Saarakkala S and Rieppo J. Infrared spectroscopic analysis of human and bovine articular cartilage proteoglycans using carbohydrate peak or its second derivative. J Biomed Opt. 2013 Sep;18(9):097006. doi: 10.1117/1.JBO.18.9.097006.

  76. te Moller NC, Brommer H, Liukkonen J, Viren T, Timonen M, Puhakka PH, Jurvelin JS, van Weeren PR and Toyras J. Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses. Vet J. 2013 Sep;197(3):589-95. doi: 10.1016/j.tvjl.2013.05.031.

  77. Vaananen SP, Amin Yavari S, Weinans H, Zadpoor AA, Jurvelin JS and Isaksson H. Repeatability of digital image correlation for measurement of surface strains in composite long bones. J Biomech. 2013 Jul 26;46(11):1928-32. doi: 10.1016/j.jbiomech.2013.05.021.

  78. Liukkonen J, Hirvasniemi J, Joukainen A, Penttila P, Viren T, Saarakkala S, Kroger H, Jurvelin JS and Toyras J. Arthroscopic ultrasound technique for simultaneous quantitative assessment of articular cartilage and subchondral bone: an in vitro and in vivo feasibility study. Ultrasound Med Biol. 2013 Aug;39(8):1460-8. doi: 10.1016/j.ultrasmedbio.2013.03.026.

  79. Julkunen P, Wilson W, Isaksson H, Jurvelin JS, Herzog W and Korhonen RK. A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading. Comput Math Methods Med. 2013;2013:326150. doi: 10.1155/2013/326150.

  80. Kulmala KA, Karjalainen HM, Kokkonen HT, Tiitu V, Kovanen V, Lammi MJ, Jurvelin JS, Korhonen RK and Toyras J. Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking--contribution of steric and electrostatic effects. Med Eng Phys. 2013 Oct;35(10):1415-20. doi: 10.1016/j.medengphy.2013.03.010.

  81. Mononen ME, Jurvelin JS and Korhonen RK. Effects of radial tears and partial meniscectomy of lateral meniscus on the knee joint mechanics during the stance phase of the gait cycle--A 3D finite element study. J Orthop Res. 2013 Aug;31(8):1208-17. doi: 10.1002/jor.22358.

  82. Mononen ME, Jurvelin JS and Korhonen RK. Implementation of a gait cycle loading into healthy and meniscectomised knee joint models with fibril-reinforced articular cartilage. Comput Methods Biomech Biomed Engin. 2015;18(2):141-52. doi: 10.1080/10255842.2013.783575.

  83. Tamminen IS, Yli-Kyyny T, Isaksson H, Turunen MJ, Tong X, Jurvelin JS and Kroger H. Incidence and bone biopsy findings of atypical femoral fractures. J Bone Miner Metab. 2013 Sep;31(5):585-94. doi: 10.1007/s00774-013-0448-7.

  84. Rieppo L, Saarakkala S, Jurvelin JS and Rieppo J. Prediction of compressive stiffness of articular cartilage using Fourier transform infrared spectroscopy. J Biomech. 2013 Apr 26;46(7):1269-75. doi: 10.1016/j.jbiomech.2013.02.022.

  85. Grassi L, Vaananen SP, Amin Yavari S, Weinans H, Jurvelin JS, Zadpoor AA and Isaksson H. Experimental validation of finite element model for proximal composite femur using optical measurements. J Mech Behav Biomed Mater. 2013 May;21:86-94. doi: 10.1016/j.jmbbm.2013.02.006.

  86. Turunen MJ, Prantner V, Jurvelin JS, Kroger H and Isaksson H. Composition and microarchitecture of human trabecular bone change with age and differ between anatomical locations. Bone. 2013 May;54(1):118-25. doi: 10.1016/j.bone.2013.01.045.

  87. Halonen KS, Mononen ME, Jurvelin JS, Toyras J and Korhonen RK. Importance of depth-wise distribution of collagen and proteoglycans in articular cartilage--a 3D finite element study of stresses and strains in human knee joint. J Biomech. 2013 Apr 5;46(6):1184-92. doi: 10.1016/j.jbiomech.2012.12.025.

  88. Malo MK, Rohrbach D, Isaksson H, Toyras J, Jurvelin JS, Tamminen IS, Kroger H and Raum K. Longitudinal elastic properties and porosity of cortical bone tissue vary with age in human proximal femur. Bone. 2013 Apr;53(2):451-8. doi: 10.1016/j.bone.2013.01.015.

  89. Hirvasniemi J, Kulmala KA, Lammentausta E, Ojala R, Lehenkari P, Kamel A, Jurvelin JS, Toyras J, Nieminen MT and Saarakkala S. In vivo comparison of delayed gadolinium-enhanced MRI of cartilage and delayed quantitative CT arthrography in imaging of articular cartilage. Osteoarthritis Cartilage. 2013 Mar;21(3):434-42. doi: 10.1016/j.joca.2012.12.009.

  90. Silvast TS, Jurvelin JS, Tiitu V, Quinn TM and Toyras J. Bath Concentration of Anionic Contrast Agents Does Not Affect Their Diffusion and Distribution in Articular Cartilage In Vitro. Cartilage. 2013 Jan;4(1):42-51. doi: 10.1177/1947603512451023.

  91. Kobrina Y, Rieppo L, Saarakkala S, Pulkkinen HJ, Tiitu V, Valonen P, Kiviranta I, Jurvelin JS and Isaksson H. Cluster analysis of infrared spectra can differentiate intact and repaired articular cartilage. Osteoarthritis Cartilage. 2013 Mar;21(3):462-9. doi: 10.1016/j.joca.2012.12.005.

  92. Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Rieppo L, Toyras J, Silvast TS, Lammi MJ and Kiviranta I. Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit. Osteoarthritis Cartilage. 2013 Mar;21(3):481-90. doi: 10.1016/j.joca.2012.12.004.

  93. Kokkonen HT, Aula AS, Kroger H, Suomalainen JS, Lammentausta E, Mervaala E, Jurvelin JS and Toyras J. Delayed Computed Tomography Arthrography of Human Knee Cartilage In Vivo. Cartilage. 2012 Oct;3(4):334-41. doi: 10.1177/1947603512447300.

  94. Kinnunen J, Kokkonen HT, Kovanen V, Hauta-Kasari M, Vahimaa P, Lammi MJ, Toyras J and Jurvelin JS. Nondestructive fluorescence-based quantification of threose-induced collagen cross-linking in bovine articular cartilage. J Biomed Opt. 2012 Sep;17(9):97003. doi: 10.1117/1.JBO.17.9.097003.

  95. Tapaninen T, Kroger H, Jurvelin J and Venesmaa P. Femoral neck bone mineral density after resurfacing hip arthroplasty. Scand J Surg. 2012;101(3):211-5. doi: 10.1177/145749691210100312.

  96. Sommer I, Erkkila AT, Jarvinen R, Mursu J, Sirola J, Jurvelin JS, Kroger H and Tuppurainen M. Alcohol consumption and bone mineral density in elderly women. Public Health Nutr. 2013 Apr;16(4):704-12. doi: 10.1017/S136898001200331X.

  97. Vaananen SP, Isaksson H, Waarsing JH, Zadpoor AA, Jurvelin JS and Weinans H. Estimation of 3D rotation of femur in 2D hip radiographs. J Biomech. 2012 Aug 31;45(13):2279-83. doi: 10.1016/j.jbiomech.2012.06.007.

  98. Rasanen LP, Mononen ME, Nieminen MT, Lammentausta E, Jurvelin JS and Korhonen RK. Implementation of subject-specific collagen architecture of cartilage into a 2D computational model of a knee joint--data from the Osteoarthritis Initiative (OAI). J Orthop Res. 2013 Jan;31(1):10-22. doi: 10.1002/jor.22175.

  99. Kulmala KA, Pulkkinen HJ, Rieppo L, Tiitu V, Kiviranta I, Brunott A, Brommer H, van Weeren R, Brama PA, Mikkola MT, Korhonen RK, Jurvelin JS and Toyras J. Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage. Cartilage. 2012 Jul;3(3):235-44. doi: 10.1177/1947603511424173.

  100. Rikkonen T, Sirola J, Salovaara K, Tuppurainen M, Jurvelin JS, Honkanen R and Kroger H. Muscle strength and body composition are clinical indicators of osteoporosis. Calcif Tissue Int. 2012 Aug;91(2):131-8. doi: 10.1007/s00223-012-9618-1.

  101. Iivarinen JT, Korhonen RK, Julkunen P and Jurvelin JS. Experimental and computational analysis of soft tissue mechanical response under negative pressure in forearm. Skin Res Technol. 2013 Feb;19(1):e356-65. doi: 10.1111/j.1600-0846.2012.00652.x.

  102. Viren T, Timonen M, Tyrvainen H, Tiitu V, Jurvelin JS and Toyras J. Ultrasonic evaluation of acute impact injury of articular cartilage in vitro. Osteoarthritis Cartilage. 2012 Jul;20(7):719-26. doi: 10.1016/j.joca.2012.03.018.

  103. Viren T, Huang YP, Saarakkala S, Pulkkinen H, Tiitu V, Linjama A, Kiviranta I, Lammi MJ, Brunott A, Brommer H, Van Weeren R, Brama PA, Zheng YP, Jurvelin JS and Toyras J. Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage. J Med Eng Technol. 2012 Apr;36(3):185-92. doi: 10.3109/03091902.2012.663054.

  104. Rieppo L, Rieppo J, Jurvelin JS and Saarakkala S. Fourier transform infrared spectroscopic imaging and multivariate regression for prediction of proteoglycan content of articular cartilage. PLoS One. 2012;7(2):e32344. doi: 10.1371/journal.pone.0032344.

  105. Kobrina Y, Rieppo L, Saarakkala S, Jurvelin JS and Isaksson H. Clustering of infrared spectra reveals histological zones in intact articular cartilage. Osteoarthritis Cartilage. 2012 May;20(5):460-8. doi: 10.1016/j.joca.2012.01.014.

  106. Rieppo L, Saarakkala S, Narhi T, Helminen HJ, Jurvelin JS and Rieppo J. Application of second derivative spectroscopy for increasing molecular specificity of Fourier transform infrared spectroscopic imaging of articular cartilage. Osteoarthritis Cartilage. 2012 May;20(5):451-9. doi: 10.1016/j.joca.2012.01.010.

  107. Turunen MJ, Toyras J, Lammi MJ, Jurvelin JS and Korhonen RK. Hyperosmolaric contrast agents in cartilage tomography may expose cartilage to overload-induced cell death. J Biomech. 2012 Feb 2;45(3):497-503. doi: 10.1016/j.jbiomech.2011.11.049.

  108. Mononen ME, Mikkola MT, Julkunen P, Ojala R, Nieminen MT, Jurvelin JS and Korhonen RK. Effect of superficial collagen patterns and fibrillation of femoral articular cartilage on knee joint mechanics-a 3D finite element analysis. J Biomech. 2012 Feb 2;45(3):579-87. doi: 10.1016/j.jbiomech.2011.11.003.

  109. Lotjonen P, Julkunen P, Tiitu V, Jurvelin JS and Toyras J. Ultrasound speed varies in articular cartilage under indentation loading. IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Dec;58(12):2772-80. doi: 10.1109/TUFFC.2011.2143.

  110. Jarvinen R, Tuppurainen M, Erkkila AT, Penttinen P, Karkkainen M, Salovaara K, Jurvelin JS and Kroger H. Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. Eur J Clin Nutr. 2012 Apr;66(4):496-503. doi: 10.1038/ejcn.2011.188.

  111. Hakulinen MA, Borg H, Hakkinen A, Parviainen T, Kiviranta I and Jurvelin JS. Influence of different DXA acquisition modes on monitoring the changes in bone mineral density after hip resurfacing arthroplasty. J Clin Densitom. 2012 Jan-Mar;15(1):72-7. doi: 10.1016/j.jocd.2011.08.002.

  112. Vaananen SP, Jurvelin JS and Isaksson H. Estimation of 3D shape, internal density and mechanics of proximal femur by combining bone mineral density images with shape and density templates. Biomech Model Mechanobiol. 2012 Jul;11(6):791-800. doi: 10.1007/s10237-011-0352-9.

  113. Saarelainen J, Kiviniemi V, Kroger H, Tuppurainen M, Niskanen L, Jurvelin J and Honkanen R. Body mass index and bone loss among postmenopausal women: the 10-year follow-up of the OSTPRE cohort. J Bone Miner Metab. 2012 Mar;30(2):208-16. doi: 10.1007/s00774-011-0305-5.

  114. Turunen MJ, Saarakkala S, Helminen HJ, Jurvelin JS and Isaksson H. Age-related changes in organization and content of the collagen matrix in rabbit cortical bone. J Orthop Res. 2012 Mar;30(3):435-42. doi: 10.1002/jor.21538.

  115. Kokkonen HT, Makela J, Kulmala KA, Rieppo L, Jurvelin JS, Tiitu V, Karjalainen HM, Korhonen RK, Kovanen V and Toyras J. Computed tomography detects changes in contrast agent diffusion after collagen cross-linking typical to natural aging of articular cartilage. Osteoarthritis Cartilage. 2011 Oct;19(10):1190-8. doi: 10.1016/j.joca.2011.07.008.

  116. Kaleva E, Viren T, Saarakkala S, Sahlman J, Sirola J, Puhakka J, Paatela T, Kroger H, Kiviranta I, Jurvelin JS and Toyras J. Arthroscopic Ultrasound Assessment of Articular Cartilage in the Human Knee Joint: A Potential Diagnostic Method. Cartilage. 2011 Jul;2(3):246-53. doi: 10.1177/1947603510391781.

  117. Iivarinen JT, Korhonen RK, Julkunen P and Jurvelin JS. Experimental and computational analysis of soft tissue stiffness in forearm using a manual indentation device. Med Eng Phys. 2011 Dec;33(10):1245-53. doi: 10.1016/j.medengphy.2011.05.015.

  118. Malo MK, Karjalainen JP, Riekkinen O, Isaksson H, Jurvelin JS and Toyras J. Effects of non-optimal focusing on dual-frequency ultrasound measurements of bone. IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Jun;58(6):1182-8. doi: 10.1109/TUFFC.2011.1928.

  119. Karjalainen JP, Riekkinen O, Toyras J, Hakulinen M, Kroger H, Rikkonen T, Salovaara K and Jurvelin JS. Multi-site bone ultrasound measurements in elderly women with and without previous hip fractures. Osteoporos Int. 2012 Apr;23(4):1287-95. doi: 10.1007/s00198-011-1682-2.

  120. Turunen MJ, Saarakkala S, Rieppo L, Helminen HJ, Jurvelin JS and Isaksson H. Comparison between infrared and Raman spectroscopic analysis of maturing rabbit cortical bone. Appl Spectrosc. 2011 Jun;65(6):595-603. doi: 10.1366/10-06193.

  121. Hakkinen A, Borg H, Hakulinen M, Jurvelin J, Anttila E, Parviainen T and Kiviranta I. Bone mineral density of the proximal femur after hip resurfacing arthroplasty: 1-year follow-up study. BMC Musculoskelet Disord. 2011 May 19;12:100. doi: 10.1186/1471-2474-12-100.

  122. Kinnunen J, Saarakkala S, Hauta-Kasari M, Vahimaa P and Jurvelin JS. Optical spectral reflectance of human articular cartilage - relationships with tissue structure, composition and mechanical properties. Biomed Opt Express. 2011 Apr 29;2(5):1394-402. doi: 10.1364/BOE.2.001394.

  123. Tamminen IS, Mayranpaa MK, Turunen MJ, Isaksson H, Makitie O, Jurvelin JS and Kroger H. Altered bone composition in children with vertebral fracture. J Bone Miner Res. 2011 Sep;26(9):2226-34. doi: 10.1002/jbmr.409.

  124. Hurtig MB, Buschmann MD, Fortier LA, Hoemann CD, Hunziker EB, Jurvelin JS, Mainil-Varlet P, McIlwraith CW, Sah RL and Whiteside RA. Preclinical Studies for Cartilage Repair: Recommendations from the International Cartilage Repair Society. Cartilage. 2011 Apr;2(2):137-52. doi: 10.1177/1947603511401905.

  125. Narhi T, Siitonen U, Lehto LJ, Hyttinen MM, Arokoski JP, Brama PA, Jurvelin JS, Helminen HJ and Julkunen P. Minor influence of lifelong voluntary exercise on composition, structure, and incidence of osteoarthritis in tibial articular cartilage of mice compared with major effects caused by growth, maturation, and aging. Connect Tissue Res. 2011 Oct;52(5):380-92. doi: 10.3109/03008207.2010.544428.

  126. Saarelainen J, Honkanen R, Kroger H, Tuppurainen M, Jurvelin JS and Niskanen L. Body fat distribution is associated with lumbar spine bone density independently of body weight in postmenopausal women. Maturitas. 2011 May;69(1):86-90. doi: 10.1016/j.maturitas.2011.02.009.

  127. Viren T, Saarakkala S, Tiitu V, Puhakka J, Kiviranta I, Jurvelin J and Toyras J. Ultrasound evaluation of mechanical injury of bovine knee articular cartilage under arthroscopic control. IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Jan;58(1):148-55. doi: 10.1109/TUFFC.2011.1781.

  128. Kokkonen HT, Jurvelin JS, Tiitu V and Toyras J. Detection of mechanical injury of articular cartilage using contrast enhanced computed tomography. Osteoarthritis Cartilage. 2011 Mar;19(3):295-301. doi: 10.1016/j.joca.2010.12.012.

  129. Kobrina Y, Isaksson H, Sinisaari M, Rieppo L, Brama PA, van Weeren R, Helminen HJ, Jurvelin JS and Saarakkala S. Infrared spectroscopy reveals both qualitative and quantitative differences in equine subchondral bone during maturation. J Biomed Opt. 2010 Nov-Dec;15(6):067003. doi: 10.1117/1.3512177.

  130. Trattnig S, Winalski CS, Marlovits S, Jurvelin JS, Welsch GH and Potter HG. Magnetic Resonance Imaging of Cartilage Repair: A Review. Cartilage. 2011 Jan;2(1):5-26. doi: 10.1177/1947603509360209.

  131. Huang YP, Saarakkala S, Toyras J, Wang LK, Jurvelin JS and Zheng YP. Effects of optical beam angle on quantitative optical coherence tomography (OCT) in normal and surface degenerated bovine articular cartilage. Phys Med Biol. 2011 Jan 21;56(2):491-509. doi: 10.1088/0031-9155/56/2/013.

  132. Timonen MA, Toyras J, Aula AS, Karjalainen JP, Riekkinen O and Jurvelin JS. Technical and practical improvements in arthroscopic indentation technique for diagnostics of articular cartilage softening. J Med Eng Technol. 2011 Jan;35(1):40-6. doi: 10.3109/03091902.2010.525684.

  133. Saarakkala S, Wang SZ, Huang YP, Jurvelin JS and Zheng YP. Characterization of center frequency and bandwidth of broadband ultrasound reflected by the articular cartilage to subchondral bone interface. Ultrasound Med Biol. 2011 Jan;37(1):112-21. doi: 10.1016/j.ultrasmedbio.2010.10.015.

  134. Prantner V, Isaksson H, Narvainen J, Lammentausta E, Nissi MJ, Avela J, Grohn OH and Jurvelin JS. NMR relaxation times of trabecular bone-reproducibility, relationships to tissue structure and effects of sample freezing. Phys Med Biol. 2010 Dec 7;55(23):7363-75. doi: 10.1088/0031-9155/55/23/012.

  135. Tamminen IS, Isaksson H, Aula AS, Honkanen E, Jurvelin JS and Kroger H. Reproducibility and agreement of micro-CT and histomorphometry in human trabecular bone with different metabolic status. J Bone Miner Metab. 2011 Jul;29(4):442-8. doi: 10.1007/s00774-010-0236-6.

  136. Kobrina Y, Turunen MJ, Saarakkala S, Jurvelin JS, Hauta-Kasari M and Isaksson H. Cluster analysis of infrared spectra of rabbit cortical bone samples during maturation and growth. Analyst. 2010 Dec;135(12):3147-55. doi: 10.1039/c0an00500b.

  137. Hakulinen MA, Borg H, Hakkinen A, Parviainen T, Kiviranta I and Jurvelin JS. Quantification of bone density of the proximal femur after hip resurfacing arthroplasty--comparison of different DXA acquisition modes. J Clin Densitom. 2010 Oct-Dec;13(4):426-32. doi: 10.1016/j.jocd.2010.07.001.

  138. Sirola J, Koistinen AK, Salovaara K, Rikkonen T, Tuppurainen M, Jurvelin JS, Honkanen R, Alhava E and Kroger H. Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women: A 15-Year Population-Based Study. J Osteoporos. 2010 Feb 22;2010:736391. doi: 10.4061/2010/736391.

  139. Aula AS, Toyras J, Tiitu V and Jurvelin JS. Simultaneous ultrasound measurement of articular cartilage and subchondral bone. Osteoarthritis Cartilage. 2010 Dec;18(12):1570-6. doi: 10.1016/j.joca.2010.09.009.

  140. Isaksson H, Malkiewicz M, Nowak R, Helminen HJ and Jurvelin JS. Rabbit cortical bone tissue increases its elastic stiffness but becomes less viscoelastic with age. Bone. 2010 Dec;47(6):1030-8. doi: 10.1016/j.bone.2010.08.015.

  141. Vaananen SP, Isaksson H, Julkunen P, Sirola J, Kroger H and Jurvelin JS. Assessment of the 3-D shape and mechanics of the proximal femur using a shape template and a bone mineral density image. Biomech Model Mechanobiol. 2011 Jul;10(4):529-38. doi: 10.1007/s10237-010-0253-3.

  142. Kinnunen J, Jurvelin JS, Makitalo J, Hauta-Kasari M, Vahimaa P and Saarakkala S. Optical spectral imaging of degeneration of articular cartilage. J Biomed Opt. 2010 Jul-Aug;15(4):046024. doi: 10.1117/1.3477190.

  143. Remvig L, Duhn P, Ullman S, Arokoski J, Jurvelin J, Safi A, Jensen F, Farholt S, Hove H and Juul-Kristensen B. Skin signs in Ehlers-Danlos syndrome: clinical tests and para-clinical methods. Scand J Rheumatol. 2010 Nov;39(6):511-7. doi: 10.3109/03009741003781977.

  144. Julkunen P, Halmesmaki EP, Iivarinen J, Rieppo L, Narhi T, Marjanen J, Rieppo J, Arokoski J, Brama PA, Jurvelin JS and Helminen HJ. Effects of growth and exercise on composition, structural maturation and appearance of osteoarthritis in articular cartilage of hamsters. J Anat. 2010 Sep;217(3):262-74. doi: 10.1111/j.1469-7580.2010.01270.x.

  145. Mononen ME, Julkunen P, Toyras J, Jurvelin JS, Kiviranta I and Korhonen RK. Alterations in structure and properties of collagen network of osteoarthritic and repaired cartilage modify knee joint stresses. Biomech Model Mechanobiol. 2011 Jun;10(3):357-69. doi: 10.1007/s10237-010-0239-1.

  146. Kulmala KA, Korhonen RK, Julkunen P, Jurvelin JS, Quinn TM, Kroger H and Toyras J. Diffusion coefficients of articular cartilage for different CT and MRI contrast agents. Med Eng Phys. 2010 Oct;32(8):878-82. doi: 10.1016/j.medengphy.2010.06.002.

  147. Tuppurainen M, Harma K, Komulainen M, Kiviniemi V, Kroger H, Honkanen R, Alhava E, Jurvelin J and Saarikoski S. Effects of continuous combined hormone replacement therapy and clodronate on bone mineral density in osteoporotic postmenopausal women: a 5-year follow-up. Maturitas. 2010 Aug;66(4):423-30. doi: 10.1016/j.maturitas.2010.04.013.

  148. Isaksson H, Harjula T, Koistinen A, Iivarinen J, Seppanen K, Arokoski JP, Brama PA, Jurvelin JS and Helminen HJ. Collagen and mineral deposition in rabbit cortical bone during maturation and growth: effects on tissue properties. J Orthop Res. 2010 Dec;28(12):1626-33. doi: 10.1002/jor.21186.

  149. Rikkonen T, Salovaara K, Sirola J, Karkkainen M, Tuppurainen M, Jurvelin J, Honkanen R, Alhava E and Kroger H. Physical activity slows femoral bone loss but promotes wrist fractures in postmenopausal women: a 15-year follow-up of the OSTPRE study. J Bone Miner Res. 2010 Nov;25(11):2332-40. doi: 10.1002/jbmr.143.

  150. Tapaninen TS, Venesmaa PK, Jurvelin JS, Miettinen HJ and Kroger HP. Alendronate reduces periprosthetic bone loss after uncemented primary total hip arthroplasty - a 5-year follow-up of 16 patients. Scand J Surg. 2010;99(1):32-7. doi: 10.1177/145749691009900108.

  151. Isaksson H, Nagao S, Malkiewicz M, Julkunen P, Nowak R and Jurvelin JS. Precision of nanoindentation protocols for measurement of viscoelasticity in cortical and trabecular bone. J Biomech. 2010 Aug 26;43(12):2410-7. doi: 10.1016/j.jbiomech.2010.04.017.

  152. Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Lammi MJ and Kiviranta I. Engineering of cartilage in recombinant human type II collagen gel in nude mouse model in vivo. Osteoarthritis Cartilage. 2010 Aug;18(8):1077-87. doi: 10.1016/j.joca.2010.05.004.

  153. Sirola J, Salovaara K, Rikkonen T, Karkkainen M, Tuppurainen M, Jurvelin JS, Honkanen R and Kroger H. Bone health-related factors and the use of bisphosphonates in community setting--15-year follow-up study. Osteoporos Int. 2011 Jan;22(1):255-64. doi: 10.1007/s00198-010-1254-x.

  154. Viren T, Saarakkala S, Jurvelin JS, Pulkkinen HJ, Tiitu V, Valonen P, Kiviranta I, Lammi MJ and Toyras J. Quantitative evaluation of spontaneously and surgically repaired rabbit articular cartilage using intra-articular ultrasound method in situ. Ultrasound Med Biol. 2010 May;36(5):833-9. doi: 10.1016/j.ultrasmedbio.2010.02.015.

  155. Kaleva E, Liukkonen J, Toyras J, Saarakkala S, Kiviranta P and Jurvelin J. 2-D finite difference time domain model of ultrasound reflection from normal and osteoarthritic human articular cartilage surface. IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Apr;57(4):892-9. doi: 10.1109/TUFFC.2010.1493.

  156. Isaksson H, Toyras J, Hakulinen M, Aula AS, Tamminen I, Julkunen P, Kroger H and Jurvelin JS. Structural parameters of normal and osteoporotic human trabecular bone are affected differently by microCT image resolution. Osteoporos Int. 2011 Jan;22(1):167-77. doi: 10.1007/s00198-010-1219-0.

  157. Karkkainen M, Tuppurainen M, Salovaara K, Sandini L, Rikkonen T, Sirola J, Honkanen R, Jurvelin J, Alhava E and Kroger H. Effect of calcium and vitamin D supplementation on bone mineral density in women aged 65-71 years: a 3-year randomized population-based trial (OSTPRE-FPS). Osteoporos Int. 2010 Dec;21(12):2047-55. doi: 10.1007/s00198-009-1167-8.

  158. Isaksson H, Turunen MJ, Rieppo L, Saarakkala S, Tamminen IS, Rieppo J, Kroger H and Jurvelin JS. Infrared spectroscopy indicates altered bone turnover and remodeling activity in renal osteodystrophy. J Bone Miner Res. 2010 Jun;25(6):1360-6. doi: 10.1002/jbmr.10.

  159. Malo MK, Karjalainen JP, Isaksson H, Riekkinen O, Jurvelin JS and Toyras J. Numerical analysis of uncertainties in dual frequency bone ultrasound technique. Ultrasound Med Biol. 2010 Feb;36(2):288-94. doi: 10.1016/j.ultrasmedbio.2009.10.008.

  160. Korhonen RK and Jurvelin JS. Compressive and tensile properties of articular cartilage in axial loading are modulated differently by osmotic environment. Med Eng Phys. 2010 Mar;32(2):155-60. doi: 10.1016/j.medengphy.2009.11.004.

  161. Julkunen P, Iivarinen J, Brama PA, Arokoski J, Jurvelin JS and Helminen HJ. Maturation of collagen fibril network structure in tibial and femoral cartilage of rabbits. Osteoarthritis Cartilage. 2010 Mar;18(3):406-15. doi: 10.1016/j.joca.2009.11.007.

  162. Julkunen P, Wilson W, Jurvelin JS and Korhonen RK. Composition of the pericellular matrix modulates the deformation behaviour of chondrocytes in articular cartilage under static loading. Med Biol Eng Comput. 2009 Dec;47(12):1281-90. doi: 10.1007/s11517-009-0547-8.

  163. Silvast TS, Kokkonen HT, Jurvelin JS, Quinn TM, Nieminen MT and Toyras J. Diffusion and near-equilibrium distribution of MRI and CT contrast agents in articular cartilage. Phys Med Biol. 2009 Nov 21;54(22):6823-36. doi: 10.1088/0031-9155/54/22/005.

  164. Rieppo L, Saarakkala S, Narhi T, Holopainen J, Lammi M, Helminen HJ, Jurvelin JS and Rieppo J. Quantitative analysis of spatial proteoglycan content in articular cartilage with Fourier transform infrared imaging spectroscopy: Critical evaluation of analysis methods and specificity of the parameters. Microsc Res Tech. 2010 May;73(5):503-12. doi: 10.1002/jemt.20789.

  165. Saarakkala S, Julkunen P, Kiviranta P, Makitalo J, Jurvelin JS and Korhonen RK. Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics. Osteoarthritis Cartilage. 2010 Jan;18(1):73-81. doi: 10.1016/j.joca.2009.08.003.

  166. Isaksson H, Tolvanen V, Finnila MA, Iivarinen J, Turunen A, Silvast TS, Tuukkanen J, Seppanen K, Arokoski JP, Brama PA, Jurvelin JS and Helminen HJ. Long-term voluntary exercise of male mice induces more beneficial effects on cancellous and cortical bone than on the collagenous matrix. Exp Gerontol. 2009 Nov;44(11):708-17. doi: 10.1016/j.exger.2009.08.005.

  167. Julkunen P, Jurvelin JS and Isaksson H. Contribution of tissue composition and structure to mechanical response of articular cartilage under different loading geometries and strain rates. Biomech Model Mechanobiol. 2010 Apr;9(2):237-45. doi: 10.1007/s10237-009-0169-y.

  168. Isaksson H, Tolvanen V, Finnila MA, Iivarinen J, Tuukkanen J, Seppanen K, Arokoski JP, Brama PA, Jurvelin JS and Helminen HJ. Physical exercise improves properties of bone and its collagen network in growing and maturing mice. Calcif Tissue Int. 2009 Sep;85(3):247-56. doi: 10.1007/s00223-009-9273-3.

  169. Julkunen P, Harjula T, Iivarinen J, Marjanen J, Seppanen K, Narhi T, Arokoski J, Lammi MJ, Brama PA, Jurvelin JS and Helminen HJ. Biomechanical, biochemical and structural correlations in immature and mature rabbit articular cartilage. Osteoarthritis Cartilage. 2009 Dec;17(12):1628-38. doi: 10.1016/j.joca.2009.07.002.

  170. Aula AS, Jurvelin JS and Toyras J. Simultaneous computed tomography of articular cartilage and subchondral bone. Osteoarthritis Cartilage. 2009 Dec;17(12):1583-8. doi: 10.1016/j.joca.2009.06.010.

  171. Kaleva E, Toyras J, Jurvelin JS, Viren T and Saarakkala S. Effects of ultrasound frequency, temporal sampling frequency, and spatial sampling step on the quantitative ultrasound parameters of articular cartilage. IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Jul;56(7):1383-93. doi: 10.1109/TUFFC.2009.1194.

  172. Viren T, Saarakkala S, Kaleva E, Nieminen HJ, Jurvelin JS and Toyras J. Minimally invasive ultrasound method for intra-articular diagnostics of cartilage degeneration. Ultrasound Med Biol. 2009 Sep;35(9):1546-54. doi: 10.1016/j.ultrasmedbio.2009.04.004.

  173. Kaleva E, Saarakkala S, Jurvelin JS, Viren T and Toyras J. Effects of ultrasound beam angle and surface roughness on the quantitative ultrasound parameters of articular cartilage. Ultrasound Med Biol. 2009 Aug;35(8):1344-51. doi: 10.1016/j.ultrasmedbio.2009.03.009.

  174. Kiviranta P, Lammentausta E, Toyras J, Nieminen HJ, Julkunen P, Kiviranta I and Jurvelin JS. Differences in acoustic properties of intact and degenerated human patellar cartilage during compression. Ultrasound Med Biol. 2009 Aug;35(8):1367-75. doi: 10.1016/j.ultrasmedbio.2009.03.003.

  175. Karjalainen JP, Toyras J, Riekkinen O, Hakulinen M and Jurvelin JS. Ultrasound backscatter imaging provides frequency-dependent information on structure, composition and mechanical properties of human trabecular bone. Ultrasound Med Biol. 2009 Aug;35(8):1376-84. doi: 10.1016/j.ultrasmedbio.2009.03.011.

  176. Lotjonen P, Julkunen P, Toyras J, Lammi MJ, Jurvelin JS and Nieminen HJ. Strain-dependent modulation of ultrasound speed in articular cartilage under dynamic compression. Ultrasound Med Biol. 2009 Jul;35(7):1177-84. doi: 10.1016/j.ultrasmedbio.2009.03.002.

  177. Julkunen P, Harjula T, Marjanen J, Helminen HJ and Jurvelin JS. Comparison of single-phase isotropic elastic and fibril-reinforced poroelastic models for indentation of rabbit articular cartilage. J Biomech. 2009 Mar 26;42(5):652-6. doi: 10.1016/j.jbiomech.2008.12.010.

  178. Remvig L, Duhn PH, Ullman S, Kobayasi T, Hansen B, Juul-Kristensen B, Jurvelin JS and Arokoski J. Skin extensibility and consistency in patients with Ehlers-Danlos syndrome and benign joint hypermobility syndrome. Scand J Rheumatol. 2009 May-Jun;38(3):227-30. doi: 10.1080/03009740802520714.

  179. Laaksonen MM, Impivaara O, Sievanen H, Viikari JS, Lehtimaki TJ, Lamberg-Allardt CJ, Karkkainen MU, Valimaki M, Heikkinen J, Kroger LM, Kroger HP, Jurvelin JS, Kahonen MA and Raitakari OT. Associations of genetic lactase non-persistence and sex with bone loss in young adulthood. Bone. 2009 May;44(5):1003-9. doi: 10.1016/j.bone.2008.12.019.

  180. Karkkainen M, Rikkonen T, Kroger H, Sirola J, Tuppurainen M, Salovaara K, Arokoski J, Jurvelin J, Honkanen R and Alhava E. Physical tests for patient selection for bone mineral density measurements in postmenopausal women. Bone. 2009 Apr;44(4):660-5. doi: 10.1016/j.bone.2008.12.010.

  181. Nieminen HJ, Zheng Y, Saarakkala S, Wang Q, Toyras J, Huang Y and Jurvelin J. Quantitative assessment of articular cartilage using high-frequency ultrasound: research findings and diagnostic prospects. Crit Rev Biomed Eng. 2009;37(6):461-94. doi: 10.1615/critrevbiomedeng.v37.i6.20.

  182. Berberat JE, Nissi MJ, Jurvelin JS and Nieminen MT. Assessment of interstitial water content of articular cartilage with T1 relaxation. Magn Reson Imaging. 2009 Jun;27(5):727-32. doi: 10.1016/j.mri.2008.09.005.

  183. Silvast TS, Jurvelin JS, Aula AS, Lammi MJ and Toyras J. Contrast agent-enhanced computed tomography of articular cartilage: association with tissue composition and properties. Acta Radiol. 2009 Jan;50(1):78-85. doi: 10.1080/02841850802572526.

  184. Aula AS, Toyras J, Hakulinen MA and Jurvelin JS. Effect of bone marrow on acoustic properties of trabecular bone--3D finite difference modeling study. Ultrasound Med Biol. 2009 Feb;35(2):308-18. doi: 10.1016/j.ultrasmedbio.2008.08.002.

  185. Karjalainen J, Riekkinen O, Toyras J, Kroger H and Jurvelin J. Ultrasonic assessment of cortical bone thickness in vitro and in vivo. IEEE Trans Ultrason Ferroelectr Freq Control. 2008 Oct;55(10):2191-7. doi: 10.1109/TUFFC.918.

  186. Rieppo J, Hyttinen MM, Halmesmaki E, Ruotsalainen H, Vasara A, Kiviranta I, Jurvelin JS and Helminen HJ. Changes in spatial collagen content and collagen network architecture in porcine articular cartilage during growth and maturation. Osteoarthritis Cartilage. 2009 Apr;17(4):448-55. doi: 10.1016/j.joca.2008.09.004.

  187. Karjalainen J, Toyras J, Rikkonen T, Jurvelin JS and Riekkinen O. Dual-frequency ultrasound technique minimizes errors induced by soft tissue in ultrasound bone densitometry. Acta Radiol. 2008 Nov;49(9):1038-41. doi: 10.1080/02841850802325982.

  188. Sirola J, Salovaara K, Tuppurainen M, Jurvelin JS, Alhava E and Kroger H. Sister's fracture history may be associated with perimenopausal bone fragility and modifies the predictability of fracture risk. Osteoporos Int. 2009 Apr;20(4):557-65. doi: 10.1007/s00198-008-0704-1.

  189. Sirola J, Rikkonen T, Tuppurainen M, Jurvelin JS, Alhava E and Kroger H. Grip strength may facilitate fracture prediction in perimenopausal women with normal BMD: a 15-year population-based study. Calcif Tissue Int. 2008 Aug;83(2):93-100. doi: 10.1007/s00223-008-9155-0.

  190. Silvast TS, Jurvelin JS, Lammi MJ and Toyras J. pQCT study on diffusion and equilibrium distribution of iodinated anionic contrast agent in human articular cartilage--associations to matrix composition and integrity. Osteoarthritis Cartilage. 2009 Jan;17(1):26-32. doi: 10.1016/j.joca.2008.05.012.

  191. Riekkinen O, Hakulinen MA, Toyras J and Jurvelin JS. Dual-frequency ultrasound--new pulse-echo technique for bone densitometry. Ultrasound Med Biol. 2008 Oct;34(10):1703-8. doi: 10.1016/j.ultrasmedbio.2008.03.018.

  192. Julkunen P, Wilson W, Jurvelin JS, Rieppo J, Qu CJ, Lammi MJ and Korhonen RK. Stress-relaxation of human patellar articular cartilage in unconfined compression: prediction of mechanical response by tissue composition and structure. J Biomech. 2008;41(9):1978-86. doi: 10.1016/j.jbiomech.2008.03.026.

  193. Julkunen P, Korhonen RK, Nissi MJ and Jurvelin JS. Mechanical characterization of articular cartilage by combining magnetic resonance imaging and finite-element analysis: a potential functional imaging technique. Phys Med Biol. 2008 May 7;53(9):2425-38. doi: 10.1088/0031-9155/53/9/014.

  194. Karkkainen M, Rikkonen T, Kroger H, Sirola J, Tuppurainen M, Salovaara K, Arokoski J, Jurvelin J, Honkanen R and Alhava E. Association between functional capacity tests and fractures: an eight-year prospective population-based cohort study. Osteoporos Int. 2008 Aug;19(8):1203-10. doi: 10.1007/s00198-008-0561-y.

  195. Kiviranta P, Lammentausta E, Toyras J, Kiviranta I and Jurvelin JS. Indentation diagnostics of cartilage degeneration. Osteoarthritis Cartilage. 2008 Jul;16(7):796-804. doi: 10.1016/j.joca.2007.10.016.

  196. Lammentausta E, Silvast TS, Narvainen J, Jurvelin JS, Nieminen MT and Grohn OH. T2, Carr-Purcell T2 and T1rho of fat and water as surrogate markers of trabecular bone structure. Phys Med Biol. 2008 Feb 7;53(3):543-55. doi: 10.1088/0031-9155/53/3/003.

  197. Kurkijarvi JE, Nissi MJ, Rieppo J, Toyras J, Kiviranta I, Nieminen MT and Jurvelin JS. The zonal architecture of human articular cartilage described by T2 relaxation time in the presence of Gd-DTPA2-. Magn Reson Imaging. 2008 Jun;26(5):602-7. doi: 10.1016/j.mri.2007.10.013.

  198. Rieppo J, Hallikainen J, Jurvelin JS, Kiviranta I, Helminen HJ and Hyttinen MM. Practical considerations in the use of polarized light microscopy in the analysis of the collagen network in articular cartilage. Microsc Res Tech. 2008 Apr;71(4):279-87. doi: 10.1002/jemt.20551.

  199. Riekkinen O, Hakulinen MA, Toyras J and Jurvelin JS. Spatial variation of acoustic properties is related with mechanical properties of trabecular bone. Phys Med Biol. 2007 Dec 7;52(23):6961-8. doi: 10.1088/0031-9155/52/23/013.

  200. Saarakkala S, Jurvelin JS, Zheng YP, Nieminen HJ and Toyras J. Quantitative information from ultrasound evaluation of articular cartilage should be interpreted with care. Arthroscopy. 2007 Oct;23(10):1137-8; author reply 1139-41. doi: 10.1016/j.arthro.2007.08.015.

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