Research Group

Jukka Sakari Jurvelin

Ph.D., Professor, Co-head of the BBC group

Personal information

  • Phone: +358 17 162530
  • Cellular: +358 40 5148507
  • Room: Me/232
  • Email: jukka.jurvelin [at] uef.fi (please fix the address before mailing!)

  • Present position: Professor of Medical Physics and Engineering, Department of Applied Physics, University of Eastern Finland, Kuopio, Finland

  • Current research interests: Biomechanics of soft and hard tissues, Bone Mineral Analysis, Biological Ultrasound, Electron Microscopy, Atomic Force Microscopy, Stereology, Nuclear Medicine Imaging, Magnetic Resonance Imaging, Finite Element Modeling, Physiological measurements and instrumentation, Quality Control

  • Current research interests: Research Associate, Department of Anatomy, University of Kuopio; Kuopio, Finland, 1983-1986; Associate Physicist, Department of Radiotherapy, Kuopio University; Hospital, Kuopio, Finland, 1988-1989; Associate Physicist, Department of Clinical Physiology, Kuopio; University Hospital, Kuopio, Finland, 1990-1991; Senior Physicist, Department of Clinical Physiology, Kuopio University; Hospital, Kuopio, Finland, 1992-2/2001; Associate Head Physicist, Department of Clinical Physiology and Nuclear medicine, Kuopio University Hospital, Kuopio, Finland, 3/2001-

  • Education:
    • Academic:
      • M. Sc. (Medical Physics), University of Kuopio, Kuopio, Finland, 1982
      • Ph. D. (Medical Physics), University of Kuopio, Kuopio, Finland, 1993
      • Docent (Biophysics), University of Kuopio, Kuopio, Finland, 1996
    • Professional:
      • Specialty of Senior Hospital Physicist, Ministry of Social Health, Finland, 1991.
    • Scientific:
      • Postdoctoral fellow, ME Müller Institute for Biomechanics, University Bern, Bern, Switzerland, 1.9.1993-31.8.1995.

  • Language proficiency
    • Finnish, native language
    • English, good
    • Swedish, fairly good
    • German, fairly good

  • Membership in scientific and professional organizations
    • Member, Editorial Consultant´s Panel, Journal of Biomechanics
    • Member, Editorial Board, Osteoarthritis & Cartilage
    • Member, OsteoArthritis Research Society International (OARSI)
    • Member, The Finnish Association of Isotope Medicine
    • Member, Association of Hospital Physicists in Finland

Publications:

The recent 50 publications
  1. Bhattarai A, ORCID: http://orcid.org/0000-0003-3713-1349, Honkanen JTJ, ORCID: http://orcid.org/0000-0002-9150-9253, Myller KAH, ORCID: http://orcid.org/0000-0001-8820-1322, Prakash M, ORCID: http://orcid.org/0000-0002-3853-4126, Korhonen M, ORCID: http://orcid.org/0000-0002-2548-4457, Saukko AEA, ORCID: http://orcid.org/0000-0001-8678-4675, Viren T, ORCID: http://orcid.org/0000-0002-7685-7911, Joukainen A, Patwa AN, Kroger H, ORCID: http://orcid.org/0000-0003-4245-8186, Grinstaff MW, ORCID: http://orcid.org/0000-0002-5453-3668, Jurvelin JS, Toyras J and ORCID: http://orcid.org/0000-0002-8035-1606. Quantitative Dual Contrast CT Technique for Evaluation of Articular Cartilage Properties. Ann Biomed Eng. 2018 Apr 13. pii: 10.1007/s10439-018-2013-y. doi:

  2. Svard T, Lakovaara M, Pakarinen H, Haapea M, Kiviranta I, Lammentausta E, Jurvelin J, Tervonen O, Ojala R and Nieminen M. Quantitative MRI of Human Cartilage In Vivo: Relationships with Arthroscopic Indentation Stiffness and Defect Severity. Cartilage. 2018 Jan;9(1):46-54. doi: 10.1177/1947603516684592. Epub 2016 Dec 28.

  3. Ojanen X, Tanska P, Malo MKH, Isaksson H, Vaananen SP, Koistinen AP, Grassi L, Magnusson SP, Ribel-Madsen SM, Korhonen RK, Jurvelin JS and Toyras J. Tissue viscoelasticity is related to tissue composition but may not fully predict the apparent-level viscoelasticity in human trabecular bone - An experimental and finite element study. J Biomech. 2017 Dec 8;65:96-105. doi: 10.1016/j.jbiomech.2017.10.002. Epub 2017

  4. Stewart RC, Honkanen JTJ, Kokkonen HT, Tiitu V, Saarakkala S, Joukainen A, Snyder BD, Jurvelin JS, Grinstaff MW and Toyras J. Contrast-Enhanced Computed Tomography Enables Quantitative Evaluation of Tissue Properties at Intrajoint Regions in Cadaveric Knee Cartilage. Cartilage. 2017 Oct;8(4):391-399. doi: 10.1177/1947603516665443. Epub 2016 Sep 1.

  5. Saukko AEA, ORCID: 0000-0001-8678-4675, Honkanen JTJ, Xu W, Vaananen SP, ORCID: 0000-0001-9803-7407, Jurvelin JS, Lehto VP, ORCID: 0000-0001-8153-1070, Toyras J and ORCID: 0000-0002-8035-1606. Dual Contrast CT Method Enables Diagnostics of Cartilage Injuries and Degeneration Using a Single CT Image. Ann Biomed Eng. 2017 Dec;45(12):2857-2866. doi: 10.1007/s10439-017-1916-3. Epub

  6. Tong X, ORCID: http://orcid.org/0000-0002-7868-0478, Malo MKH, Burton IS, Jurvelin JS, Isaksson H and Kroger H. Histomorphometric and osteocytic characteristics of cortical bone in male subtrochanteric femoral shaft. J Anat. 2017 Nov;231(5):708-717. doi: 10.1111/joa.12670. Epub 2017 Aug 7.

  7. Tong X, Burton IS, Jurvelin JS, Isaksson H and Kroger H. Iliac crest histomorphometry and skeletal heterogeneity in men. Bone Rep. 2016 Nov 28;6:9-16. doi: 10.1016/j.bonr.2016.11.004. eCollection 2017

  8. Eneh CT, Afara IO, Malo MK, Jurvelin JS and Toyras J. Porosity predicted from ultrasound backscatter using multivariate analysis can improve accuracy of cortical bone thickness assessment. J Acoust Soc Am. 2017 Jan;141(1):575. doi: 10.1121/1.4973572.

  9. Grassi L, ORCID: 0000-0001-7824-9947, Vaananen SP, Ristinmaa M, Jurvelin JS and Isaksson H. Prediction of femoral strength using 3D finite element models reconstructed from DXA images: validation against experiments. Biomech Model Mechanobiol. 2017 Jun;16(3):989-1000. doi:

  10. Ojanen X, Toyras J, Inkinen SI, Malo MK, Isaksson H and Jurvelin JS. Differences in acoustic impedance of fresh and embedded human trabecular bone samples-Scanning acoustic microscopy and numerical evaluation. J Acoust Soc Am. 2016 Sep;140(3):1931. doi: 10.1121/1.4962347.

  11. Venalainen MS, Mononen ME, Salo J, Rasanen LP, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Quantitative Evaluation of the Mechanical Risks Caused by Focal Cartilage Defects in the Knee. Sci Rep. 2016 Nov 29;6:37538. doi: 10.1038/srep37538.

  12. Kokkonen HT, Chin HC, Toyras J, Jurvelin JS and Quinn TM. Solute Transport of Negatively Charged Contrast Agents Across Articular Surface of Injured Cartilage. Ann Biomed Eng. 2017 Apr;45(4):973-981. doi: 10.1007/s10439-016-1756-6. Epub 2016

  13. Rasanen LP, Tanska P, Mononen ME, Lammentausta E, Zbyn S, Venalainen MS, Szomolanyi P, van Donkelaar CC, Jurvelin JS, Trattnig S, Nieminen MT and Korhonen RK. Spatial variation of fixed charge density in knee joint cartilage from sodium MRI - Implication on knee joint mechanics under static loading. J Biomech. 2016 Oct 3;49(14):3387-3396. doi: 10.1016/j.jbiomech.2016.09.011. Epub

  14. Myller KA, ORCID: 0000-0001-8820-1322, Turunen MJ, Honkanen JT, Vaananen SP, ORCID: 0000-0001-9803-7407, Iivarinen JT, Salo J, Jurvelin JS and Toyras J. In Vivo Contrast-Enhanced Cone Beam CT Provides Quantitative Information on Articular Cartilage and Subchondral Bone. Ann Biomed Eng. 2017 Mar;45(3):811-818. doi: 10.1007/s10439-016-1730-3. Epub 2016

  15. Saarelainen J, Hakulinen M, Rikkonen T, Kroger H, Koivumaa-Honkanen H, Honkanen R and Jurvelin JS. Inclusion of Regional Body Composition Parameters Improves Bone Mineral Density Cross-Calibration Between GE Lunar Prodigy and iDXA Densitometers. J Clin Densitom. 2017 Jan - Mar;20(1):97-105. doi: 10.1016/j.jocd.2016.07.006.

  16. Inkinen SI, Liukkonen J, Malo MK, Viren T, Jurvelin JS and Toyras J. Finite difference time domain model of ultrasound propagation in agarose scaffold containing collagen or chondrocytes. J Acoust Soc Am. 2016 Jul;140(1):1. doi: 10.1121/1.4953021.

  17. Turunen MJ, Kaspersen JD, Olsson U, Guizar-Sicairos M, Bech M, Schaff F, Tagil M, Jurvelin JS and Isaksson H. Bone mineral crystal size and organization vary across mature rat bone cortex. J Struct Biol. 2016 Sep;195(3):337-344. doi: 10.1016/j.jsb.2016.07.005. Epub 2016

  18. Puhakka J, Afara IO, Paatela T, Sormaala MJ, Timonen MA, Viren T, Jurvelin JS, Toyras J and Kiviranta I. In Vivo Evaluation of the Potential of High-Frequency Ultrasound for Arthroscopic Examination of the Shoulder Joint. Cartilage. 2016 Jul;7(3):248-55. doi: 10.1177/1947603515617280. Epub 2015 Nov 26.

  19. Saarelainen J, Hakulinen M, Rikkonen T, Kroger H, Tuppurainen M, Koivumaa-Honkanen H, Honkanen R, Hujo M and Jurvelin JS. Cross-Calibration of GE Healthcare Lunar Prodigy and iDXA Dual-Energy X-Ray Densitometers for Bone Mineral Measurements. J Osteoporos. 2016;2016:1424582. doi: 10.1155/2016/1424582. Epub 2016 Apr 27.

  20. Linder H, Malo MK, Liukkonen J, Jurvelin JS and Toyras J. Phased-array ultrasound technology enhances accuracy of dual frequency ultrasound measurements - towards improved ultrasound bone diagnostics. J Med Eng Technol. 2016 Aug;40(6):293-7. doi: 10.1080/03091902.2016.1185472. Epub

  21. Puhakka PH, Te Moller NC, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound. Acta Orthop. 2016 Aug;87(4):418-24. doi: 10.1080/17453674.2016.1180578. Epub 2016

  22. Eneh CT, Malo MK, Karjalainen JP, Liukkonen J, Toyras J and Jurvelin JS. Effect of porosity, tissue density, and mechanical properties on radial sound speed in human cortical bone. Med Phys. 2016 May;43(5):2030. doi: 10.1118/1.4942808.

  23. Rautiainen J, Nieminen MT, Salo EN, Kokkonen HT, Mangia S, Michaeli S, Grohn O, Jurvelin JS, Toyras J and Nissi MJ. Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage. Osteoarthritis Cartilage. 2016 Sep;24(9):1656-64. doi:

  24. Halonen KS, Mononen ME, Jurvelin JS, Toyras J, Klodowski A, Kulmala JP and Korhonen RK. Importance of Patella, Quadriceps Forces, and Depthwise Cartilage Structure on Knee Joint Motion and Cartilage Response During Gait. J Biomech Eng. 2016 Jul 1;138(7). pii: 2520868. doi: 10.1115/1.4033516.

  25. Honkanen JTJ, Turunen MJ, Freedman JD, Saarakkala S, Grinstaff MW, Ylarinne JH, Jurvelin JS and Toyras J. Cationic Contrast Agent Diffusion Differs Between Cartilage and Meniscus. Ann Biomed Eng. 2016 Oct;44(10):2913-2921. doi: 10.1007/s10439-016-1629-z. Epub

  26. Dahlberg LE, Aydemir A, Muurahainen N, Guhring H, Fredberg Edebo H, Krarup-Jensen N, Ladel CH and Jurvelin JS. A first-in-human, double-blind, randomised, placebo-controlled, dose ascending study of intra-articular rhFGF18 (sprifermin) in patients with advanced knee osteoarthritis. Clin Exp Rheumatol. 2016 May-Jun;34(3):445-50. Epub 2016 Mar 23.

  27. Mannicke N, Schone M, Liukkonen J, Fachet D, Inkinen S, Malo MK, Oelze ML, Toyras J, Jurvelin JS and Raum K. Species-Independent Modeling of High-Frequency Ultrasound Backscatter in Hyaline Cartilage. Ultrasound Med Biol. 2016 Jun;42(6):1375-84. doi:

  28. Venalainen MS, Mononen ME, Vaananen SP, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Effect of bone inhomogeneity on tibiofemoral contact mechanics during physiological loading. J Biomech. 2016 May 3;49(7):1111-1120. doi: 10.1016/j.jbiomech.2016.02.033. Epub

  29. Grassi L, Vaananen SP, Ristinmaa M, Jurvelin JS and Isaksson H. How accurately can subject-specific finite element models predict strains and strength of human femora? Investigation using full-field measurements. J Biomech. 2016 Mar 21;49(5):802-806. doi: 10.1016/j.jbiomech.2016.02.032. Epub

  30. Eneh CT, Liukkonen J, Malo MK, Jurvelin JS and Toyras J. Inter-individual changes in cortical bone three-dimensional microstructure and elastic coefficient have opposite effects on radial sound speed. J Acoust Soc Am. 2015 Dec;138(6):3491-9. doi: 10.1121/1.4934276.

  31. Rasanen LP, Mononen ME, Lammentausta E, Nieminen MT, Jurvelin JS and Korhonen RK. Three dimensional patient-specific collagen architecture modulates cartilage responses in the knee joint during gait. Comput Methods Biomech Biomed Engin. 2016;19(11):1225-40. doi:

  32. Penttila P, Liukkonen J, Joukainen A, Viren T, Jurvelin JS, Toyras J and Kroger H. Diagnosis of Knee Osteochondral Lesions With Ultrasound Imaging. Arthrosc Tech. 2015 Sep 14;4(5):e429-33. doi: 10.1016/j.eats.2015.04.002.

  33. Honkanen JT, ORCID: 0000-0002-9150-9253, Turunen MJ, Tiitu V, Jurvelin JS and Toyras J. Transport of Iodine Is Different in Cartilage and Meniscus. Ann Biomed Eng. 2016 Jul;44(7):2114-22. doi: 10.1007/s10439-015-1513-2. Epub 2015

  34. Karjalainen JP, Riekkinen O, Toyras J, Jurvelin JS and Kroger H. New method for point-of-care osteoporosis screening and diagnostics. Osteoporos Int. 2016 Mar;27(3):971-977. doi: 10.1007/s00198-015-3387-4. Epub 2015

  35. Iivarinen JT, Korhonen RK and Jurvelin JS. Modeling of interstitial fluid movement in soft tissue under negative pressure--relevance to treatment of tissue swelling. Comput Methods Biomech Biomed Engin. 2016;19(10):1089-98. doi:

  36. Afara IO, Hauta-Kasari M, Jurvelin JS, Oloyede A and Toyras J. Optical absorption spectra of human articular cartilage correlate with biomechanical properties, histological score and biochemical composition. Physiol Meas. 2015 Sep;36(9):1913-28. doi: 10.1088/0967-3334/36/9/1913. Epub 2015

  37. Ryd L, Brittberg M, Eriksson K, Jurvelin JS, Lindahl A, Marlovits S, Moller P, Richardson JB, Steinwachs M and Zenobi-Wong M. Pre-Osteoarthritis: Definition and Diagnosis of an Elusive Clinical Entity. Cartilage. 2015 Jul;6(3):156-65. doi: 10.1177/1947603515586048.

  38. Vaananen SP, Grassi L, Flivik G, Jurvelin JS and Isaksson H. Generation of 3D shape, density, cortical thickness and finite element mesh of proximal femur from a DXA image. Med Image Anal. 2015 Aug;24(1):125-134. doi: 10.1016/j.media.2015.06.001. Epub

  39. Puhakka PH, Te Moller NCR, Afara IO, Makela JTA, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. Osteoarthritis Cartilage. 2015 Dec;23(12):2206-2213. doi:

  40. Turunen MJ, Toyras J, Kokkonen HT and Jurvelin JS. Quantitative evaluation of knee subchondral bone mineral density using cone beam computed tomography. IEEE Trans Med Imaging. 2015 Oct;34(10):2186-90. doi: 10.1109/TMI.2015.2426684.

  41. Inkinen SI, Liukkonen J, Tiitu V, Viren T, Jurvelin JS and Toyras J. Ultrasound Backscattering Is Anisotropic in Bovine Articular Cartilage. Ultrasound Med Biol. 2015 Jul;41(7):1958-66. doi:

  42. Honkanen JT, Danso EK, Suomalainen JS, Tiitu V, Korhonen RK, Jurvelin JS and Toyras J. Contrast enhanced imaging of human meniscus using cone beam CT. Osteoarthritis Cartilage. 2015 Aug;23(8):1367-76. doi:

  43. Arokoski ME, Tiitu V, Jurvelin JS, Korhonen RK and Fick JM. Topographical investigation of changes in depth-wise proteoglycan distribution in rabbit femoral articular cartilage at 4 weeks after transection of the anterior cruciate ligament. J Orthop Res. 2015 Sep;33(9):1278-86. doi: 10.1002/jor.22906. Epub 2015 May 21.

  44. Danso EK, Makela JT, Tanska P, Mononen ME, Honkanen JT, Jurvelin JS, Toyras J, Julkunen P and Korhonen RK. Characterization of site-specific biomechanical properties of human meniscus-Importance of collagen and fluid on mechanical nonlinearities. J Biomech. 2015 Jun 1;48(8):1499-507. doi: 10.1016/j.jbiomech.2015.01.048. Epub

  45. Tong X, Burton IS, Isaksson H, Jurvelin JS and Kroger H. Cortical bone histomorphometry in male femoral neck: the investigation of age-association and regional differences. Calcif Tissue Int. 2015 Apr;96(4):295-306. doi: 10.1007/s00223-015-9957-9. Epub

  46. Ojanen X, Isaksson H, Toyras J, Turunen MJ, Malo MK, Halvari A and Jurvelin JS. Relationships between tissue composition and viscoelastic properties in human trabecular bone. J Biomech. 2015 Jan 21;48(2):269-75. doi: 10.1016/j.jbiomech.2014.11.034. Epub

  47. Florea C, Malo MK, Rautiainen J, Makela JT, Fick JM, Nieminen MT, Jurvelin JS, Davidescu A and Korhonen RK. Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2015 Mar;23(3):414-22. doi: 10.1016/j.joca.2014.11.023.

  48. Venalainen MS, Mononen ME, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Importance of material properties and porosity of bone on mechanical response of articular cartilage in human knee joint--a two-dimensional finite element study. J Biomech Eng. 2014 Dec;136(12):121005. doi: 10.1115/1.4028801.

  49. Puhakka PH, Ylarinne JH, Lammi MJ, Saarakkala S, Tiitu V, Kroger H, Viren T, Jurvelin JS and Toyras J. Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds. Phys Med Biol. 2014 Nov 7;59(21):6537-48. doi: 10.1088/0031-9155/59/21/6537. Epub

  50. Grassi L, Vaananen SP, Yavari SA, Jurvelin JS, Weinans H, Ristinmaa M, Zadpoor AA and Isaksson H. Full-field strain measurement during mechanical testing of the human femur at physiologically relevant strain rates. J Biomech Eng. 2014 Nov;136(11). pii: 1901145. doi: 10.1115/1.4028415.

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