Research Group

Mikael Juhani Turunen
Ph.D.


Post doctoral researcher

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Personal information

  • Phone:
    Work: +358 50 5777355
    Personal: +358 44 3447499
  • Room: Sn/3134
  • Email: mikael.turunen [at] uef.fi (please fix the address before mailing!)

  • Date of birth: 10 August 1984

  • Current position: Post doctoral fellow (Finnish Academy), UEF

  • Current research interests: Bone fracture mechanisms and fracture criterion in nano- and microscale in healthy and osteoporotic bone.

  • Previous research experience:
    • Visiting Post doctoral fellow, Department of Biomedical Engineering, Lund University, Apr-Oct 2017
    • Post doctoral researcher, Department of Applied Physics, UEF, Oct 2013 - Aug 2015
    • Post doctoral researcher, Department of Biomedical Engineering, Lund University, Feb-May 2015
    • Doctoral student, Department of Applied Physics, UEF, Aug 2010 - Sep 2013
    • Part-time research assistant, Department of Applied Physics, University of Kuopio, Jun 2009 - Jun 2010

  • Education:
    • Ph.D., Medical Physics, University of Eastern Finland, 2013
    • M.Sc., Medical Physics, University of Eastern Finland, 2010
    • B.Sc., Medical Physics, University of Eastern Finland, 2010
    • Graduate of Finnish Secondary School, Kuopion musiikkilukio, 2003

  • Doctoral dissertation:
    Spectroscopic Characterization of Bone Composition - Alterations during Bone Formation, Maturation and Aging

  • Language proficiency:
    • Finnish, native language
    • English, fluent
    • Swedish, fair
    • German, fair

  • Membership in professional organizations:
    • European Society of Radiology (ESR)
    • European Society of Biomechanics (ESB)
    • Finnish Bone Society (FBS)
    • Finnish Society of Medical Physics and Medical Engineering (LFTY)
    • Finnish Synchrotron Radiation User Organization (FSRUO)
    • National Doctoral Programme of Musculoskeletal Disorders and Biomaterials (TBDP)
    • Orthopaedic Research Society (ORS)
    • Radiological Society of Finland (SRY)

  • Significant funding & awards:
    • Finnish Academy Post doctoral fellow, 2015-2018
    • ESB Travel Award, 2013

  • Reviews for Scientific Journals:
    • Acta Biomaterialia
    • Aging and Disease
    • Applied Sciences
    • Biomechanics and Modeling in Mechanobiology
    • Clinical Interventions in Aging
    • Frontiers in Physics
    • IBMS BoneKEy
    • Journal of Biomedical Optics
    • Journal of Orthopaedic Research
    • Journal of Structural Biology
    • Symmetry

Publications: (h-index: 11, Citations)

Full papers listed in PubMed

  1. Gustafsson A, Mathavan N, Turunen MJ, Engqvist J, Khayyeri H, Hall SA and Isaksson H. Linking multiscale deformation to microstructure in cortical bone using in situ loading, digital image correlation and synchrotron X-ray scattering. Acta Biomater. 2018 Mar 15;69:323-331. doi: 10.1016/j.actbio.2018.01.037.

  2. Mathavan N, Turunen MJ, Guizar-Sicairos M, Bech M, Schaff F, Tagil M and Isaksson H. The compositional and nano-structural basis of fracture healing in healthy and osteoporotic bone. Sci Rep. 2018 Jan 25;8(1):1591. doi: 10.1038/s41598-018-19296-z.

  3. Khayyeri H, Blomgran P, Hammerman M, Turunen MJ, Lowgren A, Guizar-Sicairos M, Aspenberg P and Isaksson H. Achilles tendon compositional and structural properties are altered after unloading by botox. Sci Rep. 2017 Oct 12;7(1):13067. doi: 10.1038/s41598-017-13107-7.

  4. Turunen MJ, Khayyeri H, Guizar-Sicairos M and Isaksson H. Effects of tissue fixation and dehydration on tendon collagen nanostructure. J Struct Biol. 2017 Sep;199(3):209-215. doi: 10.1016/j.jsb.2017.07.009.

  5. Isaksson H, Le Cann S, Perdikouri C, Turunen MJ, Kaestner A, Tagil M, Hall SA and Tudisco E. Neutron tomographic imaging of bone-implant interface: Comparison with X-ray tomography. Bone. 2017 Oct;103:295-301. doi: 10.1016/j.bone.2017.07.022.

  6. Myller KA, Turunen MJ, Honkanen JT, Vaananen SP, Iivarinen JT, Salo J, Jurvelin JS and Toyras J. In Vivo Contrast-Enhanced Cone Beam CT Provides Quantitative Information on Articular Cartilage and Subchondral Bone. Ann Biomed Eng. 2017 Mar;45(3):811-818. doi: 10.1007/s10439-016-1730-3.

  7. Turunen MJ, Kaspersen JD, Olsson U, Guizar-Sicairos M, Bech M, Schaff F, Tagil M, Jurvelin JS and Isaksson H. Bone mineral crystal size and organization vary across mature rat bone cortex. J Struct Biol. 2016 Sep;195(3):337-344. doi: 10.1016/j.jsb.2016.07.005.

  8. Honkanen JTJ, Turunen MJ, Freedman JD, Saarakkala S, Grinstaff MW, Ylarinne JH, Jurvelin JS and Toyras J. Cationic Contrast Agent Diffusion Differs Between Cartilage and Meniscus. Ann Biomed Eng. 2016 Oct;44(10):2913-2921. doi: 10.1007/s10439-016-1629-z.

  9. Kaspersen JD, Turunen MJ, Mathavan N, Lages S, Pedersen JS, Olsson U and Isaksson H. Small-Angle X-ray Scattering Demonstrates Similar Nanostructure in Cortical Bone from Young Adult Animals of Different Species. Calcif Tissue Int. 2016 Jul;99(1):76-87. doi: 10.1007/s00223-016-0120-z.

  10. Honkanen JT, Turunen MJ, Tiitu V, Jurvelin JS and Toyras J. Transport of Iodine Is Different in Cartilage and Meniscus. Ann Biomed Eng. 2016 Jul;44(7):2114-22. doi: 10.1007/s10439-015-1513-2.

  11. Turunen MJ, Toyras J, Kokkonen HT and Jurvelin JS. Quantitative evaluation of knee subchondral bone mineral density using cone beam computed tomography. IEEE Trans Med Imaging. 2015 Oct;34(10):2186-90. doi: 10.1109/TMI.2015.2426684.

  12. Mathavan N, Turunen MJ, Tagil M and Isaksson H. Characterising bone material composition and structure in the ovariectomized (OVX) rat model of osteoporosis. Calcif Tissue Int. 2015 Aug;97(2):134-44. doi: 10.1007/s00223-015-9991-7.

  13. Ojanen X, Isaksson H, Toyras J, Turunen MJ, Malo MK, Halvari A and Jurvelin JS. Relationships between tissue composition and viscoelastic properties in human trabecular bone. J Biomech. 2015 Jan 21;48(2):269-75. doi: 10.1016/j.jbiomech.2014.11.034.

  14. Turunen MJ, Lages S, Labrador A, Olsson U, Tagil M, Jurvelin JS and Isaksson H. Evaluation of composition and mineral structure of callus tissue in rat femoral fracture. J Biomed Opt. 2014 Feb;19(2):025003. doi: 10.1117/1.JBO.19.2.025003.

  15. Tamminen IS, Misof BM, Roschger P, Mayranpaa MK, Turunen MJ, Isaksson H, Kroger H, Makitie O and Klaushofer K. Increased heterogeneity of bone matrix mineralization in pediatric patients prone to fractures: a biopsy study. J Bone Miner Res. 2014;29(5):1110-7. doi: 10.1002/jbmr.2124.

  16. Tamminen IS, Yli-Kyyny T, Isaksson H, Turunen MJ, Tong X, Jurvelin JS and Kroger H. Incidence and bone biopsy findings of atypical femoral fractures. J Bone Miner Metab. 2013 Sep;31(5):585-94. doi: 10.1007/s00774-013-0448-7.

  17. Turunen MJ, Prantner V, Jurvelin JS, Kroger H and Isaksson H. Composition and microarchitecture of human trabecular bone change with age and differ between anatomical locations. Bone. 2013 May;54(1):118-25. doi: 10.1016/j.bone.2013.01.045.

  18. Turunen MJ, Toyras J, Lammi MJ, Jurvelin JS and Korhonen RK. Hyperosmolaric contrast agents in cartilage tomography may expose cartilage to overload-induced cell death. J Biomech. 2012 Feb 2;45(3):497-503. doi: 10.1016/j.jbiomech.2011.11.049.

  19. Turunen MJ, Saarakkala S, Helminen HJ, Jurvelin JS and Isaksson H. Age-related changes in organization and content of the collagen matrix in rabbit cortical bone. J Orthop Res. 2012 Mar;30(3):435-42. doi: 10.1002/jor.21538.

  20. Turunen MJ, Saarakkala S, Rieppo L, Helminen HJ, Jurvelin JS and Isaksson H. Comparison between infrared and Raman spectroscopic analysis of maturing rabbit cortical bone. Appl Spectrosc. 2011 Jun;65(6):595-603. doi: 10.1366/10-06193.

  21. Tamminen IS, Mayranpaa MK, Turunen MJ, Isaksson H, Makitie O, Jurvelin JS and Kroger H. Altered bone composition in children with vertebral fracture. J Bone Miner Res. 2011 Sep;26(9):2226-34. doi: 10.1002/jbmr.409.

  22. Kobrina Y, Turunen MJ, Saarakkala S, Jurvelin JS, Hauta-Kasari M and Isaksson H. Cluster analysis of infrared spectra of rabbit cortical bone samples during maturation and growth. Analyst. 2010 Dec;135(12):3147-55. doi: 10.1039/c0an00500b.

  23. Isaksson H, Turunen MJ, Rieppo L, Saarakkala S, Tamminen IS, Rieppo J, Kroger H and Jurvelin JS. Infrared spectroscopy indicates altered bone turnover and remodeling activity in renal osteodystrophy. J Bone Miner Res. 2010 Jun;25(6):1360-6. doi: 10.1002/jbmr.10.

    Full papers not listed in PubMed

  24. Huttunen JMJ, Turunen MJ, Honkanen JTJ, Töyräs J and Jurvelin JS. Estimation of systematic and spatially correlated components of random signals from repeated measurements: Application to contrast enhanced CT measurements. SIAM J Sci Comput. 2016 Jan;38(1):B77-B99. doi: 10.1137/15M1017727

  25. Singh SP, Parviainen I, Dekker H, Schulten EAJM, ten Bruggenkate CM, Bravenboer N, Mikkonen JJ, Turunen MJ, Koistinen AP and Kullaa AM. Raman microspectroscopy demonstrates alterations in human mandibular bone after radiotherapy. J Anal Bioanal Tech. 2015 Sep;6(6):276. doi: 10.4172/2155-9872.1000276

Conference proceedings

  1. Turunen MJ, Le Cann S, Tudisco E, Lovric G, Hall SA and Isaksson H. Repetitive Synchrotron X-ray Radiation May Alter Bone Collagen and Mineral. Accepted to Annual meeting of the Orthopaedic Research Society, New Orleans, LA, 2018.

  2. Podium presentation: Gustafsson A, Mathavan N, Turunen MJ, Khayyeri H, Hall S and Isaksson H. Linking bone damage to microsctuctural and multiscale deformation using in situ loading with SAXS/WAXS. ESB Annual Congress, Seville, Spain, 2017.

  3. Podium presentation: Le Cann S, Tudisco E, Perdikouri C, Belfrage O, Turunen MJ, Kaestner A, Hall S, Tägil M and Isaksson H. Neutron tomography and in situ mechanical testing to characterize the bome-implant interface. 3rd International Conference on tomography on materials and Structures, Lund, Sweden, 2017.

  4. Turunen MJ, Khayyeri H, Guizar-Sicairos M, Aspenberg P and Isaksson H. Effects of Sample Preparation and Dehydration on Tendon Collagen Nanostructure. Annual meeting of the Orthopaedic Research Society, San Diego, CA, 2017.

  5. Isaksson H, Tudisco E, Perdikouri C, Le Cann S, Turunen MJ, Kaestner A, Tägil M and Hall S. Neutron tomographic imaging of bone-implant ingrowth. Annual meeting of the Orthopaedic Research Society, San Diego, CA, 2017.

  6. Tanska P, Ojanen X, Väänänen SP, Malo MKH, Turunen MJ, Töyräs J, Isaksson H, Korhonen RK and Jurvelin JS. Viscoelastic Contribution of Calcified and Collagen Matrices in Trabecular Bone in Nanoindentation. Annual meeting of the Orthopaedic Research Society, San Diego, CA, 2017.

  7. Podium presentation: Khayyeri H, Sepanloo P, Hammerman M, Turunen MJ, Aspenberg P and Isaksson H. Link between composition and mechanical behavior in immobilized healthy achilles tendons. ESB Annual Congress, Lyon, France, 2016.

  8. Podium presentation: Le Cann S, Tudisco E, Turunen MJ, Belfrage O, Hall S, Tägil M and Isaksson H. Tomographic X-ray imaging of bone-implant ingrowth with in situ mechanical testing. ESB Annual Congress, Lyon, France, 2016.

  9. Turunen MJ, Kaspersen JD, Bech M, Schaff F, Tägil M, Olsson U, Jurvelin JS and Isaksson H. Bone mineral crystal size and organization vary across rat bone cortex. Annual meeting of the Orthopaedic Research Society, Orlando, FL, 2016.

  10. Turunen MJ, Töyräs J, Kokkonen H and Jurvelin JS. Mineral density of subchondral bone may be quantitatively evaluated using a clinical cone beam computed tomography scanner. Annual meeting of the Orthopaedic Research Society, Las Vegas, NV, 2015.

  11. Honkanen JTJ, Turunen MJ, Tiitu V, Jurvelin JS and Töyräs J. Diffusion rate and equilibrium partition of an anionic contrast agent are different in cartilage and meniscus. Annual meeting of the Orthopaedic Research Society, Las Vegas, NV, 2015.

  12. Mathavan N, Turunen MJ, Bech M, Schaff F, Olsson U, Tägil M and Isaksson H. Characterization of composition and structure of callus tissue in fractures treated with BMP-7 and Zoledronate in an osteoporotic rat model. Annual meeting of the Orthopaedic Research Society, Las Vegas, NV, 2015.

  13. Turunen MJ, Jurvelin JS and Korhonen RK. Automated determination of zone thicknesses of articular cartilage based on chondrocyte shapes. World Congress of Biomechanics 2014.

  14. Mathavan N, Turunen MJ, Tägil M and Isaksson H. Investigating new characteristics of bone quality in the ovariectomized rat model of osteoporosis. World Congress of Biomechanics 2014.

  15. Mathavan N, Turunen MJ, Tägil M and Isaksson H. Elucidating the influence of ovariectomy-induced osteoporosis on the efficacy of fracture healing treatments in rats. Annual meeting of the Orthopaedic Research Society, New Orleans, LA, 2014.

  16. Podium presentation: Turunen MJ, Lages S, Labrador A, Olsson U, Tägil M, Jurvelin JS and Isaksson H. Composition and mineral structure of callus tissue during fracture healing. ESB Annual Congress, Patras, Greece, 2013.

  17. Podium presentation: Malo MKH, Riekkinen O, Turunen MJ, Isaksson H, Karjalainen JP, Töyräs J, and Jurvelin JS. In Situ Ultrasound Backscatter Measurements at Trochanter Major. ESUCB2013, Granada, Spain, 2013.

  18. Podium presentation: Turunen MJ, Prantner V, Jurvelin JS, Kröger H and Isaksson H. Composition and structure of human trabecular bone in different anatomical locations. ESB Annual Congress, Lisbon, Portugal, 2012.

  19. Podium presentation: Turunen MJ, Jurvelin JS, Kröger H and Isaksson H. Composition of human trabecular bone changes with age and differs between anatomical locations; evaluation with FTIR. Annual meeting of the Orthopaedic Research Society, San Fransisco, CA, 2012.

  20. Podium presentation: Turunen MJ, Bosemark P, Tägil M and Isaksson H. Local molecular composition in callus tissue of rats during bone healing: assessed by IR-spectroscopy. Baltic Bone and Cartilage Conference, Malmö, Sweden, 2011.

  21. Turunen MJ, Saarakkala S, Helminen HJ, Jurvelin JS and Isaksson H. Age-related changes in the composition and organization of the organic matrix in rabbit cortical bone. Annual meeting of the Orthopaedic Research Society, Long Beach, CA, 2011.

  22. Podium presentation: Kobrina Y, Turunen MJ, Saarakkala S, Jurvelin JS, Hauta-Kasari M and Isaksson H. Cluster analysis of infrared spectra of rabbit cortical bone samples during maturation and growth. The 6th International SPEC conference, Manchester, Great-Britain, 2010.

  23. Tamminen I, Mäyränpää M, Turunen MJ, Isaksson H, Mäkitie O, Jurvelin JS and Kröger H. Altered bone composition in fracture prone children with vertebral fracture. Annual meeting of the American Society for Bone and Mineral Research, Toronto, Canada, 2010.

  24. Turunen MJ, Saarakkala S, Rieppo L, Helminen HJ, Jurvelin JS and Isaksson H. Changes in rabbit bone composition during maturation - A comparison between Infrared and Raman microspectroscopy. Annual meeting of the Orthopaedic Research Society, New Orleans, LA, 2010.

  25. Podium presentation: Isaksson H, Turunen M, Rieppo L, Saarakkala S, Rieppo J, Kröger H and Jurvelin JS. Spectroscopic characterization of altered bone composition following osteoporosis or renal osteodystrophy. Annual meeting of the Orthopaedic Research Society, Las Vegas, NV, 2009.

  26. Töyras J, Turunen M, Lammi M, Jurvelin JS and Korhonen RK. Hyperosmolaric Contrast Agents in Cartilage Tomography May Expose Cartilage to Overload-Induced Cell Death. Annual meeting of the Orthopaedic Research Society, Las Vegas, NV, 2009.

Under review:

  1. Huang L, Korhonen RK, Turunen MJ and Finnilä MAJ. Experimental strain measurement of tissue and cells.

  2. Saukko AEA, Turunen MJ, Korhonen M, Lovric G, Tiitu V, Honkanen JTJ, Grinstaff MW, Jurvelin JS and Töyräs J. Simultaneous quantitation of cationic and non-ionic contrast agents in articular cartilage using synchrotron microCT imaging.

Contact: +358 20 7872211 (Switch), email: bbc-l [at] lists.uef.fi