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Mikko Finnila, Ph.D.

Post-doc Researcher

Cell and tissue imaging

Medical physics Oulu

Personal information

  • Phone: +358 50 3501894
  • Room: Me/331
  • Email: mikko.finnila [at] (please fix the address before mailing!)

  • Current research interests: Bone, teeth and cartilage morphology, mechanics; bone remodeling; osteocytes and mechanotracduction, in-vivo imaging

  • Education:
    • Doctor of Philosophy, Biomedicine, Department of Anatomy and Cell Biology, University of Oulu, Oulu, 2014.
    • Master of Health Science, Medical and Wellness Technology / Biomedical Technology, University of Oulu, June 2008
    • Matriculation examination, Haapajärvi High School, 2003.

  • Language proficiency:
    • Finnish, native language
    • English, fluent

  • Skills:
    • µ-CT imaging, infrared microspectroscopy, image analysis
    • Programming: Matlab


(full papers, conference proceedings)
  1. Mustonen AM, ORCID:, Kakela R, Finnila MAJ, Sawatsky A, Korhonen RK, Saarakkala S, Herzog W, Paakkonen T and Nieminen P. Anterior cruciate ligament transection alters the n-3/n-6 fatty acid balance in the lapine infrapatellar fat pad. Lipids Health Dis. 2019 Mar 18;18(1):67. doi: 10.1186/s12944-019-1008-5.

  2. Huang L, Korhonen RK, Turunen MJ and Finnila MAJ. Experimental mechanical strain measurement of tissues. PeerJ. 2019 Mar 7;7:e6545. doi: 10.7717/peerj.6545. eCollection 2019.

  3. Ylitalo T, Finnila MAJ, Gahunia HK, Karhula SS, Suhonen H, Valkealahti M, Lehenkari P, Haeggstrom E, Pritzker KPH, Saarakkala S and Nieminen HJ. Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses. J Orthop Res. 2019 Feb 9. doi: 10.1002/jor.24245.

  4. Ebrahimi M, ORCID:, Ojanen S, Mohammadi A, Finnila MA, Joukainen A, Kroger H, Saarakkala S, Korhonen RK and Tanska P. Elastic, Viscoelastic and Fibril-Reinforced Poroelastic Material Properties of Healthy and Osteoarthritic Human Tibial Cartilage. Ann Biomed Eng. 2019 Apr;47(4):953-966. doi: 10.1007/s10439-019-02213-4. Epub

  5. Vidal B, Cascao R, Finnila MAJ, Lopes IP, da Gloria VG, Saarakkala S, Zioupos P, Canhao H and Fonseca JE. Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model. Rheumatology (Oxford). 2019 Feb 1;58(2):371. doi: 10.1093/rheumatology/key377.

  6. Kauppinen S, Karhula SS, Thevenot J, Ylitalo T, Rieppo L, Kestila I, Haapea M, Hadjab I, Finnila MA, Quenneville E, Garon M, Gahunia HK, Pritzker KPH, Buschmann MD, Saarakkala S and Nieminen HJ. 3D morphometric analysis of calcified cartilage properties using micro-computed tomography. Osteoarthritis Cartilage. 2019 Jan;27(1):172-180. doi:

  7. Ketola JH, Karhula SS, Finnila MAJ, ORCID:, Korhonen RK, Herzog W, Siltanen S, Nieminen MT and Saarakkala S. Iterative and discrete reconstruction in the evaluation of the rabbit model of osteoarthritis. Sci Rep. 2018 Aug 13;8(1):12051. doi: 10.1038/s41598-018-30334-8.

  8. Oinas J, Ronkainen AP, Rieppo L, Finnila MAJ, ORCID:, Iivarinen JT, van Weeren PR, Helminen HJ, Brama PAJ, Korhonen RK and Saarakkala S. Composition, structure and tensile biomechanical properties of equine articular cartilage during growth and maturation. Sci Rep. 2018 Jul 27;8(1):11357. doi: 10.1038/s41598-018-29655-5.

  9. Persson M, Lehenkari PP, Berglin L, Turunen S, Finnila MAJ, ORCID:, Risteli J, Skrifvars M, Tuukkanen J and ORCID: Osteogenic Differentiation of Human Mesenchymal Stem cells in a 3D Woven Scaffold. Sci Rep. 2018 Jul 11;8(1):10457. doi: 10.1038/s41598-018-28699-x.

  10. Kestila I, Thevenot J, Finnila MA, Karhula SS, Hadjab I, Kauppinen S, Garon M, Quenneville E, Haapea M, Rieppo L, Pritzker KP, Buschmann MD, Nieminen HJ and Saarakkala S. In vitro method for 3D morphometry of human articular cartilage chondrons based on micro-computed tomography. Osteoarthritis Cartilage. 2018 Aug;26(8):1118-1126. doi:

  11. Ojanen SP, ORCID: 0000-0003-4386-0716, Finnila MAJ, Reunamo AE, Ronkainen AP, Mikkonen S, Herzog W, Saarakkala S and Korhonen RK. Site-specific glycosaminoglycan content is better maintained in the pericellular matrix than the extracellular matrix in early post-traumatic osteoarthritis. PLoS One. 2018 Apr 25;13(4):e0196203. doi: 10.1371/journal.pone.0196203.

  12. Vidal B, ORCID: 0000-0003-2906-4705, Cascao R, Finnila MAJ, Lopes IP, Saarakkala S, Zioupos P, Canhao H and Fonseca JE. Early arthritis induces disturbances at bone nanostructural level reflected in decreased tissue hardness in an animal model of arthritis. PLoS One. 2018 Jan 9;13(1):e0190920. doi: 10.1371/journal.pone.0190920.

  13. Vidal B, Cascao R, Finnila MAJ, Lopes IP, da Gloria VG, Saarakkala S, Zioupos P, Canhao H and Fonseca JE. Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model. Rheumatology (Oxford). 2018 Aug 1;57(8):1461-1471. doi:

  14. Nieminen HJ, ORCID: 0000-0001-6084-1272, Barreto G, Finnila MA, Garcia-Perez A, Salmi A, Ranjan S, Eklund KK, ORCID: 0000-0002-5870-4663, Pritzker KPH, Saarakkala S and Haeggstrom E. Laser-ultrasonic delivery of agents into articular cartilage. Sci Rep. 2017 Jun 21;7(1):3991. doi: 10.1038/s41598-017-04293-5.

  15. Mustonen AJ, ORCID: 0000-0003-2266-2518, Finnila MAJ, Puukka KS, Jamsa TJ, Saarakkala S, Tuukkanen JK and Nieminen TP. Raccoon dog model shows preservation of bone during prolonged catabolism and reduced physical activity. J Exp Biol. 2017 Jun 15;220(Pt 12):2196-2202. doi: 10.1242/jeb.135475. Epub 2017

  16. Nair RR, Keratar JM, Autio KJ, Masud AJ, Finnila MAJ, Autio-Harmainen HI, Miinalainen IJ, Nieminen PA, Hiltunen JK and Kastaniotis AJ. Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice. Hum Mol Genet. 2017 Jun 1;26(11):2104-2117. doi: 10.1093/hmg/ddx105.

  17. Karhula SS, Finnila MA, Lammi MJ, Ylarinne JH, Kauppinen S, Rieppo L, Pritzker KP, Nieminen HJ and Saarakkala S. Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography. PLoS One. 2017 Jan 30;12(1):e0171075. doi: 10.1371/journal.pone.0171075.

  18. Oinas J, Rieppo L, Finnila MA, Valkealahti M, Lehenkari P and Saarakkala S. Imaging of Osteoarthritic Human Articular Cartilage using Fourier Transform Infrared Microspectroscopy Combined with Multivariate and Univariate Analysis. Sci Rep. 2016 Jul 21;6:30008. doi: 10.1038/srep30008.

  19. Finnila MAJ, Thevenot J, Aho OM, Tiitu V, Rautiainen J, Kauppinen S, Nieminen MT, Pritzker K, Valkealahti M, Lehenkari P and Saarakkala S. Association between subchondral bone structure and osteoarthritis histopathological grade. J Orthop Res. 2017 Apr;35(4):785-792. doi: 10.1002/jor.23312. Epub 2016 Jun 22.

  20. Koskela A, Finnila MA, Korkalainen M, Spulber S, Koponen J, Hakansson H, Tuukkanen J and Viluksela M. Effects of developmental exposure to perfluorooctanoic acid (PFOA) on long bone morphology and bone cell differentiation. Toxicol Appl Pharmacol. 2016 Jun 15;301:14-21. doi: 10.1016/j.taap.2016.04.002.

  21. Hirvasniemi J, Thevenot J, Kokkonen HT, Finnila MA, Venalainen MS, Jamsa T, Korhonen RK, Toyras J and Saarakkala S. Correlation of Subchondral Bone Density and Structure from Plain Radiographs with Micro Computed Tomography Ex Vivo. Ann Biomed Eng. 2016 May;44(5):1698-709. doi: 10.1007/s10439-015-1452-y. Epub

  22. Nieminen P, Huitu O, Henttonen H, Finnila MA, Voutilainen L, Itamies J, Karja V, Saarela S, Halonen T, Aho J and Mustonen AM. Physiological condition of bank voles (Myodes glareolus) during the increase and decline phases of the population cycle. Comp Biochem Physiol A Mol Integr Physiol. 2015 Sep;187:141-9. doi:

  23. Rautiainen J, Nissi MJ, Salo EN, Tiitu V, Finnila MAJ, Aho OM, Saarakkala S, Lehenkari P, Ellermann J and Nieminen MT. Multiparametric MRI assessment of human articular cartilage degeneration: Correlation with quantitative histology and mechanical properties. Magn Reson Med. 2015 Jul;74(1):249-259. doi: 10.1002/mrm.25401. Epub 2014 Aug 7.

  24. Herlin M, Finnila MA, Zioupos P, Aula A, Risteli J, Miettinen HM, Jamsa T, Tuukkanen J, Korkalainen M, Hakansson H and Viluksela M. New insights to the role of aryl hydrocarbon receptor in bone phenotype and in dioxin-induced modulation of bone microarchitecture and material properties. Toxicol Appl Pharmacol. 2013 Nov 15;273(1):219-26. doi:

  25. Elabbas LE, Herlin M, Finnila MA, Rendel F, Stern N, Trossvik C, Bowers WJ, Nakai J, Tuukkanen J, Viluksela M, Heimeier RA, Akesson A and Hakansson H. In utero and lactational exposure to Aroclor 1254 affects bone geometry, mineral density and biomechanical properties of rat offspring. Toxicol Lett. 2011 Nov 10;207(1):82-8. doi: 10.1016/j.toxlet.2011.08.003. Epub

  26. Elabbas LE, Finnila MA, Herlin M, Stern N, Trossvik C, Bowers WJ, Nakai J, Tuukkanen J, Heimeier RA, Akesson A and Hakansson H. Perinatal exposure to environmental contaminants detected in Canadian Arctic human populations changes bone geometry and biomechanical properties in rat offspring. J Toxicol Environ Health A. 2011;74(19):1304-18. doi:

  27. Huesa C, Yadav MC, Finnila MA, Goodyear SR, Robins SP, Tanner KE, Aspden RM, Millan JL and Farquharson C. PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures. Bone. 2011 May 1;48(5):1066-74. doi: 10.1016/j.bone.2011.01.010. Epub 2011 Jan

  28. Nieminen P, Finnila MA, Tuukkanen J, Jamsa T and Mustonen AM. Preservation of bone mass and biomechanical properties during winter sleep--the raccoon dog (Nyctereutes procyonoides) as a novel model species. Bone. 2011 Apr 1;48(4):878-84. doi: 10.1016/j.bone.2010.12.001. Epub 2010 Dec 10.

  29. Finnila MA, Zioupos P, Herlin M, Miettinen HM, Simanainen U, Hakansson H, Tuukkanen J, Viluksela M and Jamsa T. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on bone material properties. J Biomech. 2010 Apr 19;43(6):1097-103. doi: 10.1016/j.jbiomech.2009.12.011. Epub

  30. Isaksson H, Tolvanen V, Finnila MA, Iivarinen J, Turunen A, Silvast TS, Tuukkanen J, Seppanen K, Arokoski JP, Brama PA, Jurvelin JS and Helminen HJ. Long-term voluntary exercise of male mice induces more beneficial effects on cancellous and cortical bone than on the collagenous matrix. Exp Gerontol. 2009 Nov;44(11):708-17. doi: 10.1016/j.exger.2009.08.005. Epub 2009

  31. Isaksson H, Tolvanen V, Finnila MA, Iivarinen J, Tuukkanen J, Seppanen K, Arokoski JP, Brama PA, Jurvelin JS and Helminen HJ. Physical exercise improves properties of bone and its collagen network in growing and maturing mice. Calcif Tissue Int. 2009 Sep;85(3):247-56. doi: 10.1007/s00223-009-9273-3. Epub

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