Research Group



Mikko Laasanen
Ph.D.
 

Personal information

Publications:

  1. Florea C, Tanska P, Mononen ME, Qu C, Lammi MJ, Laasanen MS and Korhonen RK. A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells. Biomech Model Mechanobiol. 2017 Feb;16(1):297-311. doi:

  2. Koski JM, Alasaarela E, Soini I, Kemppainen K, Hakulinen U, Heikkinen JO, Laasanen MS and Saarakkala S. Ability of ultrasound imaging to detect erosions in a bone phantom model. Ann Rheum Dis. 2010 Sep;69(9):1618-22. doi: 10.1136/ard.2009.126680. Epub 2010

  3. Nissi MJ, Rieppo J, Toyras J, Laasanen MS, Kiviranta I, Nieminen MT and Jurvelin JS. Estimation of mechanical properties of articular cartilage with MRI - dGEMRIC, T2 and T1 imaging in different species with variable stages of maturation. Osteoarthritis Cartilage. 2007 Oct;15(10):1141-8. doi:

  4. Kiviranta P, Toyras J, Nieminen MT, Laasanen MS, Saarakkala S, Nieminen HJ, Nissi MJ and Jurvelin JS. Comparison of novel clinically applicable methodology for sensitive diagnostics of cartilage degeneration. Eur Cell Mater. 2007 Apr 3;13:46-55; discussion 55.

  5. Saarakkala S, Laasanen MS, Jurvelin JS and Toyras J. Quantitative ultrasound imaging detects degenerative changes in articular cartilage surface and subchondral bone. Phys Med Biol. 2006 Oct 21;51(20):5333-46. doi: 10.1088/0031-9155/51/20/017. Epub

  6. Nieminen HJ, Toyras J, Laasanen MS and Jurvelin JS. Acoustic properties of articular cartilage under mechanical stress. Biorheology. 2006;43(3,4):523-35.

  7. Nissi MJ, Rieppo J, Toyras J, Laasanen MS, Kiviranta I, Jurvelin JS and Nieminen MT. T(2) relaxation time mapping reveals age- and species-related diversity of collagen network architecture in articular cartilage. Osteoarthritis Cartilage. 2006 Dec;14(12):1265-71. doi:

  8. Pulkkinen H, Tiitu V, Lammentausta E, Laasanen MS, Hamalainen ER, Kiviranta I and Lammi MJ. Cellulose sponge as a scaffold for cartilage tissue engineering. Biomed Mater Eng. 2006;16(4 Suppl):S29-35.

  9. Brommer H, Laasanen MS, Brama PA, van Weeren PR, Helminen HJ and Jurvelin JS. In situ and ex vivo evaluation of an arthroscopic indentation instrument to estimate the health status of articular cartilage in the equine metacarpophalangeal joint. Vet Surg. 2006 Apr;35(3):259-66. doi: 10.1111/j.1532-950X.2006.00136.x.

  10. Lammentausta E, Kiviranta P, Nissi MJ, Laasanen MS, Kiviranta I, Nieminen MT and Jurvelin JS. T2 relaxation time and delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) of human patellar cartilage at 1.5 T and 9.4 T: Relationships with tissue mechanical properties. J Orthop Res. 2006 Mar;24(3):366-74. doi: 10.1002/jor.20041.

  11. Laasanen MS, Toyras J, Vasara A, Saarakkala S, Hyttinen MM, Kiviranta I and Jurvelin JS. Quantitative ultrasound imaging of spontaneous repair of porcine cartilage. Osteoarthritis Cartilage. 2006 Mar;14(3):258-63. doi: 10.1016/j.joca.2005.09.011.

  12. Laasanen MS, Saarakkala S, Toyras J, Rieppo J and Jurvelin JS. Site-specific ultrasound reflection properties and superficial collagen content of bovine knee articular cartilage. Phys Med Biol. 2005 Jul 21;50(14):3221-33. doi: 10.1088/0031-9155/50/14/002. Epub

  13. Brommer H, Laasanen MS, Brama PA, van Weeren PR, Helminen HJ and Jurvelin JS. Functional consequences of cartilage degeneration in the equine metacarpophalangeal joint: quantitative assessment of cartilage stiffness. Equine Vet J. 2005 Sep;37(5):462-7.

  14. Brommer H, Laasanen MS, Brama PA, van Weeren PR, Barneveld A, Helminen HJ and Jurvelin JS. Influence of age, site, and degenerative state on the speed of sound in equine articular cartilage. Am J Vet Res. 2005 Jul;66(7):1175-80.

  15. Laasanen MS, Heikkinen JO, Saarakkala S and Paajanen H. Localization of sentinel nodes in breast cancer: novel method and device to help pen marking of active nodes during gamma camera imaging. Phys Med Biol. 2005 Apr 7;50(7):N49-54. doi: 10.1088/0031-9155/50/7/N01. Epub

  16. Brommer H, Brama PA, Laasanen MS, Helminen HJ, van Weeren PR and Jurvelin JS. Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis. Equine Vet J. 2005 Mar;37(2):148-54.

  17. Lammi MJ, Qu CJ, Laasanen MS, Saarakkala S, Rieppo J, Jurvelin JS and Toyras J. Undersulfated chondroitin sulfate does not increase in osteoarthritic cartilage. J Rheumatol. 2004 Dec;31(12):2449-53.

  18. Saarakkala S, Korhonen RK, Laasanen MS, Toyras J, Rieppo J and Jurvelin JS. Mechano-acoustic determination of Young's modulus of articular cartilage. Biorheology. 2004;41(3-4):167-79.

  19. Saarakkala S, Toyras J, Hirvonen J, Laasanen MS, Lappalainen R and Jurvelin JS. Ultrasonic quantitation of superficial degradation of articular cartilage. Ultrasound Med Biol. 2004 Jun;30(6):783-92. doi:

  20. Nieminen HJ, Saarakkala S, Laasanen MS, Hirvonen J, Jurvelin JS and Toyras J. Ultrasound attenuation in normal and spontaneously degenerated articular cartilage. Ultrasound Med Biol. 2004 Apr;30(4):493-500. doi:

  21. Nissi MJ, Toyras J, Laasanen MS, Rieppo J, Saarakkala S, Lappalainen R, Jurvelin JS and Nieminen MT. Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage. J Orthop Res. 2004 May;22(3):557-64. doi: 10.1016/j.orthres.2003.09.008.

  22. Nieminen MT, Toyras J, Laasanen MS, Silvennoinen J, Helminen HJ and Jurvelin JS. Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging. J Biomech. 2004 Mar;37(3):321-8.

  23. Saarakkala S, Laasanen MS, Jurvelin JS, Torronen K, Lammi MJ, Lappalainen R and Toyras J. Ultrasound indentation of normal and spontaneously degenerated bovine articular cartilage. Osteoarthritis Cartilage. 2003 Sep;11(9):697-705.

  24. Korhonen RK, Laasanen MS, Toyras J, Lappalainen R, Helminen HJ and Jurvelin JS. Fibril reinforced poroelastic model predicts specifically mechanical behavior of normal, proteoglycan depleted and collagen degraded articular cartilage. J Biomech. 2003 Sep;36(9):1373-9.

  25. Laasanen MS, Saarakkala S, Toyras J, Hirvonen J, Rieppo J, Korhonen RK and Jurvelin JS. Ultrasound indentation of bovine knee articular cartilage in situ. J Biomech. 2003 Sep;36(9):1259-67.

  26. Korhonen RK, Saarakkala S, Toyras J, Laasanen MS, Kiviranta I and Jurvelin JS. Experimental and numerical validation for the novel configuration of an arthroscopic indentation instrument. Phys Med Biol. 2003 Jun 7;48(11):1565-76.

  27. Laasanen MS, Toyras J, Vasara AI, Hyttinen MM, Saarakkala S, Hirvonen J, Jurvelin JS and Kiviranta I. Mechano-acoustic diagnosis of cartilage degeneration and repair. J Bone Joint Surg Am. 2003;85-A Suppl 2:78-84.

  28. Toyras J, Laasanen MS, Saarakkala S, Lammi MJ, Rieppo J, Kurkijarvi J, Lappalainen R and Jurvelin JS. Speed of sound in normal and degenerated bovine articular cartilage. Ultrasound Med Biol. 2003 Mar;29(3):447-54.

  29. Laasanen MS, Toyras J, Korhonen RK, Rieppo J, Saarakkala S, Nieminen MT, Hirvonen J and Jurvelin JS. Biomechanical properties of knee articular cartilage. Biorheology. 2003;40(1-3):133-40.

  30. Laasanen MS, Toyras J, Hirvonen J, Saarakkala S, Korhonen RK, Nieminen MT, Kiviranta I and Jurvelin JS. Novel mechano-acoustic technique and instrument for diagnosis of cartilage degeneration. Physiol Meas. 2002 Aug;23(3):491-503.

  31. Toyras J, Nieminen HJ, Laasanen MS, Nieminen MT, Korhonen RK, Rieppo J, Hirvonen J, Helminen HJ and Jurvelin JS. Ultrasonic characterization of articular cartilage. Biorheology. 2002;39(1-2):161-9.

  32. Korhonen RK, Laasanen MS, Toyras J, Rieppo J, Hirvonen J, Helminen HJ and Jurvelin JS. Comparison of the equilibrium response of articular cartilage in unconfined compression, confined compression and indentation. J Biomech. 2002 Jul;35(7):903-9.

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