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Laboratory engineer

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Research Group

Mikko Juhani Lammi
Ph.D., Research Director
WoS ResearcherID

Tissue and cell biology

Personal information

  • Phone: +358 040 5870601
  • Room: Me/330
  • Email: mikko.lammi[at]uef.fi (please fix the address before mailing!)

  • Date of birth: 29 December 1961

  • Current research interests: Tissue engineering, cartilage repair, chondrogenic differentiation, biomaterials, Kashin-Beck disease

  • Education:
    • Title of Docent (Cell Biology), University of Kuopio, Kuopio, 1999
    • Ph.D. (biochemistry), University of Kuopio, Kuopio, 1993
    • M.Sc., University of Kuopio, Kuopio, 1986

  • Language proficiency:
    • Finnish, native language
    • English, fluent
    • Swedish, good
    • German, fairly good

  • Skills:
  • Cell Biology, tissue engineering, cartilage repair.

  • Hobbies: Music, rock concerts, science fiction (Star Trek and Babylon 5)

Publications:

(full papers, conference proceedings)

  1. Prittinen J, Ylarinne J, Piltti J, Karhula SS, Rieppo L, Ojanen SP, Korhonen RK, Saarakkala S, Lammi MJ and Qu C. Effect of centrifugal force on the development of articular neocartilage with bovine primary chondrocytes. Cell Tissue Res. 2018 Oct 23. pii: 10.1007/s00441-018-2938-3. doi: 10.1007/s00441-018-2938-3.

  2. Lammi MJ, ORCID: 0000-0002-6181-9904, Piltti J, ORCID: 0000-0002-1732-4269, Prittinen J, Qu C and ORCID: 0000-0002-1710-7715. Challenges in Fabrication of Tissue-Engineered Cartilage with Correct Cellular Colonization and Extracellular Matrix Assembly. Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092700. doi: 10.3390/ijms19092700.

  3. Qu C, Kaitainen S, Kroger H, Lappalainen R and Lammi MJ. Behavior of Human Bone Marrow-Derived Mesenchymal Stem Cells on Various Titanium-Based Coatings. Materials (Basel). 2016 Oct 12;9(10). pii: ma9100827. doi: 10.3390/ma9100827.

  4. Arasu UT, Karna R, Harkonen K, Oikari S, Koistinen A, Kroger H, Qu C, Lammi MJ and Rilla K. Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles. Matrix Biol. 2017 Dec;64:54-68. doi: 10.1016/j.matbio.2017.05.001. Epub 2017 May 5.

  5. Rieppo L, Kokkonen HT, Kulmala KA, Kovanen V, Lammi MJ, Toyras J and Saarakkala S. Infrared microspectroscopic determination of collagen cross-links in articular cartilage. J Biomed Opt. 2017 Mar 1;22(3):35007. doi: 10.1117/1.JBO.22.3.035007.

  6. Karhula SS, Finnila MA, Lammi MJ, Ylarinne JH, Kauppinen S, Rieppo L, Pritzker KP, Nieminen HJ and Saarakkala S. Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography. PLoS One. 2017 Jan 30;12(1):e0171075. doi: 10.1371/journal.pone.0171075. eCollection 2017.

  7. Florea C, Tanska P, Mononen ME, Qu C, Lammi MJ, Laasanen MS and Korhonen RK. A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells. Biomech Model Mechanobiol. 2017 Feb;16(1):297-311. doi: 10.1007/s10237-016-0817-y. Epub 2016 Aug 23.

  8. Piltti J, Varjosalo M, Qu C, Hayrinen J and Lammi MJ. Rho-kinase inhibitor Y-27632 increases cellular proliferation and migration in human foreskin fibroblast cells. Proteomics. 2015 Sep;15(17):2953-65. doi: 10.1002/pmic.201400417. Epub 2015 Jun 15.

  9. Karjalainen HM, Qu C, Leskela SS, Rilla K and Lammi MJ. Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions. Amino Acids. 2015 Mar;47(3):561-70. doi: 10.1007/s00726-014-1888-7. Epub 2014 Dec 14.

  10. Puhakka PH, Ylarinne JH, Lammi MJ, Saarakkala S, Tiitu V, Kroger H, Viren T, Jurvelin JS and Toyras J. Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds. Phys Med Biol. 2014 Nov 7;59(21):6537-48. doi: 10.1088/0031-9155/59/21/6537. Epub 2014 Oct 13.

  11. Fick JM, Huttu MR, Lammi MJ and Korhonen RK. In vitro glycation of articular cartilage alters the biomechanical response of chondrocytes in a depth-dependent manner. Osteoarthritis Cartilage. 2014 Oct;22(10):1410-8. doi: 10.1016/j.joca.2014.07.020.

  12. Prittinen J, Jiang Y, Ylarinne JH, Pakkanen TA, Lammi MJ and Qu C. Chondrocyte behavior on nanostructured micropillar polypropylene and polystyrene surfaces. Mater Sci Eng C Mater Biol Appl. 2014 Oct;43:424-31. doi: 10.1016/j.msec.2014.07.045. Epub 2014 Jul 19.

  13. Ylarinne JH, Qu C and Lammi MJ. Hypertonic conditions enhance cartilage formation in scaffold-free primary chondrocyte cultures. Cell Tissue Res. 2014 Nov;358(2):541-50. doi: 10.1007/s00441-014-1970-1. Epub 2014 Aug 9.

  14. Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ and Lammi MJ. Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthritis Cartilage. 2014 Nov;22(11):1774-83. doi: 10.1016/j.joca.2014.07.023. Epub 2014 Aug 12.

  15. Inkinen S, Liukkonen J, Ylarinne JH, Puhakka PH, Lammi MJ, Viren T, Jurvelin JS and Toyras J. Collagen and chondrocyte concentrations control ultrasound scattering in agarose scaffolds. Ultrasound Med Biol. 2014 Sep;40(9):2162-71. doi: 10.1016/j.ultrasmedbio.2014.03.016. Epub 2014 Jun 25.

  16. Qu C, Hirviniemi M, Tiitu V, Jurvelin JS, Toyras J and Lammi MJ. Effects of Freeze-Thaw Cycle with and without Proteolysis Inhibitors and Cryopreservant on the Biochemical and Biomechanical Properties of Articular Cartilage. Cartilage. 2014 Apr;5(2):97-106. doi: 10.1177/1947603513515998.

  17. Qu C, Rilla K, Tammi R, Tammi M, Kroger H and Lammi MJ. Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3. Int J Biochem Cell Biol. 2014 Mar;48:45-54. doi: 10.1016/j.biocel.2013.12.016. Epub 2014 Jan 6.

  18. Qu C, Myllymaa S, Prittinen J, Koistinen AP, Lappalainen R and Lammi MJ. Osteoblast behavior on various ultra short pulsed laser deposited surface coatings. Mater Sci Eng C Mater Biol Appl. 2013 Apr 1;33(3):1676-82. doi: 10.1016/j.msec.2012.12.078. Epub 2012 Dec 31.

  19. Huttu M, Turunen S, Sokolinski V, Tiitu V, Lammi M and Korhonen RK. Effects of medium and temperature on cellular responses in the superficial zone of hypo-osmotically challenged articular cartilage. J Funct Biomater. 2012 Sep;3(3):544-55. doi: 10.3390/jfb3030544.

  20. Qu C, Puttonen KA, Lindeberg H, Ruponen M, Hovatta O, Koistinaho J and Lammi MJ. Chondrogenic differentiation of human pluripotent stem cells in chondrocyte co-culture. Int J Biochem Cell Biol. 2013 Aug;45(8):1802-12. doi: 10.1016/j.biocel.2013.05.029. Epub 2013 Jun 2.

  21. Kulmala KA, Karjalainen HM, Kokkonen HT, Tiitu V, Kovanen V, Lammi MJ, Jurvelin JS, Korhonen RK and Toyras J. Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking--contribution of steric and electrostatic effects. Med Eng Phys. 2013 Oct;35(10):1415-20. doi: 10.1016/j.medengphy.2013.03.010. Epub 2013 Apr 24.

  22. Kaitainen S, Mahonen AJ, Lappalainen R, Kroger H, Lammi MJ and Qu C. TiO2 coating promotes human mesenchymal stem cell proliferation without the loss of their capacity for chondrogenic differentiation. Biofabrication. 2013 Jun;5(2):025009. doi: 10.1088/1758-5082/5/2/025009. Epub 2013 Apr 17.

  23. Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Rieppo L, Toyras J, Silvast TS, Lammi MJ and Kiviranta I. Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit. Osteoarthritis Cartilage. 2013 Mar;21(3):481-90. doi: 10.1016/j.joca.2012.12.004. Epub 2012 Dec 17.

  24. Kinnunen J, Kokkonen HT, Kovanen V, Hauta-Kasari M, Vahimaa P, Lammi MJ, Toyras J and Jurvelin JS. Nondestructive fluorescence-based quantification of threose-induced collagen cross-linking in bovine articular cartilage. J Biomed Opt. 2012 Sep;17(9):97003. doi: 10.1117/1.JBO.17.9.097003.

  25. Turunen SM, Lammi MJ, Saarakkala S, Han SK, Herzog W, Tanska P and Korhonen RK. The effect of collagen degradation on chondrocyte volume and morphology in bovine articular cartilage following a hypotonic challenge. Biomech Model Mechanobiol. 2013 Jun;12(3):417-29. doi: 10.1007/s10237-012-0409-4. Epub 2012 Jun 19.

  26. Viren T, Huang YP, Saarakkala S, Pulkkinen H, Tiitu V, Linjama A, Kiviranta I, Lammi MJ, Brunott A, Brommer H, Van Weeren R, Brama PA, Zheng YP, Jurvelin JS and Toyras J. Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage. J Med Eng Technol. 2012 Apr;36(3):185-92. doi: 10.3109/03091902.2012.663054.

  27. Qu C, Lindeberg H, Ylarinne JH and Lammi MJ. Five percent oxygen tension is not beneficial for neocartilage formation in scaffold-free cell cultures. Cell Tissue Res. 2012 Apr;348(1):109-17. doi: 10.1007/s00441-012-1366-z. Epub 2012 Mar 6.

  28. Turunen MJ, Toyras J, Lammi MJ, Jurvelin JS and Korhonen RK. Hyperosmolaric contrast agents in cartilage tomography may expose cartilage to overload-induced cell death. J Biomech. 2012 Feb 2;45(3):497-503. doi: 10.1016/j.jbiomech.2011.11.049. Epub 2011 Dec 27.

  29. Turunen SM, Lammi MJ, Saarakkala S, Koistinen A and Korhonen RK. Hypotonic challenge modulates cell volumes differently in the superficial zone of intact articular cartilage and cartilage explant. Biomech Model Mechanobiol. 2012 May;11(5):665-75. doi: 10.1007/s10237-011-0341-z. Epub 2011 Aug 30.

  30. Pollanen R, Tikkanen AM, Lammi MJ and Lappalainen R. The effect of loading and material on the biomechanical properties and vitality of bovine cartilage in vitro. J Appl Biomater Biomech. 2011 Jan-Apr;9(1):47-53. doi: 10.5301/JABB.2011.6472.

  31. Langsjo TK, Vasara AI, Hyttinen MM, Lammi MJ, Kaukinen A, Helminen HJ and Kiviranta I. Quantitative analysis of collagen network structure and fibril dimensions in cartilage repair with autologous chondrocyte transplantation. Cells Tissues Organs. 2010;192(6):351-60. doi: 10.1159/000319469. Epub 2010 Jul 26.

  32. Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Lammi MJ and Kiviranta I. Engineering of cartilage in recombinant human type II collagen gel in nude mouse model in vivo. Osteoarthritis Cartilage. 2010 Aug;18(8):1077-87. doi: 10.1016/j.joca.2010.05.004. Epub 2010 May 28.

  33. Olkku A, Leskinen JJ, Lammi MJ, Hynynen K and Mahonen A. Ultrasound-induced activation of Wnt signaling in human MG-63 osteoblastic cells. Bone. 2010 Aug;47(2):320-30. doi: 10.1016/j.bone.2010.04.604. Epub 2010 May 7.

  34. Viren T, Saarakkala S, Jurvelin JS, Pulkkinen HJ, Tiitu V, Valonen P, Kiviranta I, Lammi MJ and Toyras J. Quantitative evaluation of spontaneously and surgically repaired rabbit articular cartilage using intra-articular ultrasound method in situ. Ultrasound Med Biol. 2010 May;36(5):833-9. doi: 10.1016/j.ultrasmedbio.2010.02.015.

  35. Myllymaa S, Myllymaa K, Korhonen H, Lammi MJ, Tiitu V and Lappalainen R. Surface characterization and in vitro biocompatibility assessment of photosensitive polyimide films. Colloids Surf B Biointerfaces. 2010 Apr 1;76(2):505-11. doi: 10.1016/j.colsurfb.2009.12.011. Epub 2009 Dec 22.

  36. Rieppo L, Saarakkala S, Narhi T, Holopainen J, Lammi M, Helminen HJ, Jurvelin JS and Rieppo J. Quantitative analysis of spatial proteoglycan content in articular cartilage with Fourier transform infrared imaging spectroscopy: Critical evaluation of analysis methods and specificity of the parameters. Microsc Res Tech. 2010 May;73(5):503-12. doi: 10.1002/jemt.20789.

  37. Julkunen P, Harjula T, Iivarinen J, Marjanen J, Seppanen K, Narhi T, Arokoski J, Lammi MJ, Brama PA, Jurvelin JS and Helminen HJ. Biomechanical, biochemical and structural correlations in immature and mature rabbit articular cartilage. Osteoarthritis Cartilage. 2009 Dec;17(12):1628-38. doi: 10.1016/j.joca.2009.07.002. Epub 2009 Jul 8.

  38. Myllymaa K, Myllymaa S, Korhonen H, Lammi MJ, Saarenpaa H, Suvanto M, Pakkanen TA, Tiitu V and Lappalainen R. Improved adherence and spreading of Saos-2 cells on polypropylene surfaces achieved by surface texturing and carbon nitride coating. J Mater Sci Mater Med. 2009 Nov;20(11):2337-47. doi: 10.1007/s10856-009-3792-3. Epub 2009 Jun 9.

  39. Qu CJ, Poytakangas T, Jauhiainen M, Auriola S and Lammi MJ. Glucosamine sulphate does not increase extracellular matrix production at low oxygen tension. Cell Tissue Res. 2009 Jul;337(1):103-11. doi: 10.1007/s00441-009-0797-7. Epub 2009 May 14.

  40. Lotjonen P, Julkunen P, Toyras J, Lammi MJ, Jurvelin JS and Nieminen HJ. Strain-dependent modulation of ultrasound speed in articular cartilage under dynamic compression. Ultrasound Med Biol. 2009 Jul;35(7):1177-84. doi: 10.1016/j.ultrasmedbio.2009.03.002. Epub 2009 May 7.

  41. Pulkkinen HJ, Tiitu V, Valonen P, Hamalainen ER, Lammi MJ and Kiviranta I. Recombinant human type II collagen as a material for cartilage tissue engineering. Int J Artif Organs. 2008 Nov;31(11):960-9.

  42. Tiitu V, Pulkkinen HJ, Valonen P, Kiviranta O, Kiekara T, Kiviranta I and Lammi MJ. Recombinant human collagens as scaffold materials for chondrocyte cultures. Biomed Mater Eng. 2008;18(4-5):225-9.

  43. Silvast TS, Jurvelin JS, Aula AS, Lammi MJ and Toyras J. Contrast agent-enhanced computed tomography of articular cartilage: association with tissue composition and properties. Acta Radiol. 2009 Jan;50(1):78-85. doi: 10.1080/02841850802572526.

  44. Tiitu V, Pulkkinen HJ, Valonen P, Pulliainen O, Kellomaki M, Lammi MJ and Kiviranta I. Bioreactor improves the growth and viability of chondrocytes in the knitted poly-L,D-lactide scaffold. Biorheology. 2008;45(3-4):539-46.

  45. Leskinen JJ, Karjalainen HM, Olkku A, Hynynen K, Mahonen A and Lammi MJ. Genome-wide microarray analysis of MG-63 osteoblastic cells exposed to ultrasound. Biorheology. 2008;45(3-4):345-54.

  46. Piltti J, Hayrinen J, Karjalainen HM and Lammi MJ. Proteomics of chondrocytes with special reference to phosphorylation changes of proteins in stretched human chondrosarcoma cells. Biorheology. 2008;45(3-4):323-35.

  47. Silvast TS, Jurvelin JS, Lammi MJ and Toyras J. pQCT study on diffusion and equilibrium distribution of iodinated anionic contrast agent in human articular cartilage--associations to matrix composition and integrity. Osteoarthritis Cartilage. 2009 Jan;17(1):26-32. doi: 10.1016/j.joca.2008.05.012. Epub 2008 Jul 7.

  48. Julkunen P, Wilson W, Jurvelin JS, Rieppo J, Qu CJ, Lammi MJ and Korhonen RK. Stress-relaxation of human patellar articular cartilage in unconfined compression: prediction of mechanical response by tissue composition and structure. J Biomech. 2008;41(9):1978-86. doi: 10.1016/j.jbiomech.2008.03.026. Epub 2008 May 19.

  49. Riekkinen O, Hakulinen MA, Lammi MJ, Jurvelin JS, Kallioniemi A and Toyras J. Acoustic properties of trabecular bone--relationships to tissue composition. Ultrasound Med Biol. 2007 Sep;33(9):1438-44. doi: 10.1016/j.ultrasmedbio.2007.04.004. Epub 2007 Jun 11.

  50. Pulliainen O, Vasara AI, Hyttinen MM, Tiitu V, Valonen P, Kellomaki M, Jurvelin JS, Peterson L, Lindahl A, Kiviranta I and Lammi MJ. Poly-L-D-lactic acid scaffold in the repair of porcine knee cartilage lesions. Tissue Eng. 2007 Jun;13(6):1347-55. doi: 10.1089/ten.2006.0347.

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