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Group overview
Juha's group
Rami's group
Petro's group
Mikko's group
Personal profiles
Group leaders
Juha Töyräs
Rami Korhonen
Petro Julkunen
Jukka Jurvelin
Mikko Nissi
Isaac Afara
Mika Mononen
Post Doc researchers
Timo Leppänen
Sami Myllymaa
Janne Mäkelä
Ervin Nippolainen
Rubina Shaikh
Lauri Stenroth
Petri Tanska
Mikael Turunen
Ph.D. Students
Juho Ala-Myllymäki
Abhisek Bhattarai
Paul Bolcos
Mohammadhossein Ebrahimi
Atte Eskelinen
Amir Esrafilian
Lingwei Huang
Minna Husso
Laura Kalevo
Samu Kainulainen
Shahab Khakpour
Shohreh Kariminezhad
Miitu Korhonen
Henri Korkalainen
Akseli Leino
Aleksi Leinonen
Mimmi Liukkonen
Tomi Miettinen
Ali Mohammadi
Katariina Myller
Sami Nikkonen
Mikko Nissinen
Olli Nykänen
Simo Ojanen
Gustavo Orozco
Antti Paajanen
Petri Paakkari
Mithilesh Prakash
Jusa Reijonen
Aapo Ristaniemi
Jukka Saari
Jaakko Sarin
Annina Saukko
Jari Torniainen
Swetha Turkapally
Soile Törmälehto
Nikae te Moller (Utrecht)
Tytti Niemelä (Helsinki)
Nina Hänninen (Oulu)
Brett Duce (Brisbane)
Olli Löfberg (Kuopio)
Abdul Wahed Kajabi (Oulu)
Shahab Khakpour (Oulu)
Laboratory engineer
Teemu Laitinen
Active Collaborators
Mikko Finnilä
Cristina Florea
Hanna Isaksson
Juuso Honkanen
Eveliina Lammentausta
Mikko Lammi
Miika Nieminen
Pia Puhakka
Lassi Rieppo
Simo Saarakkala
Mikko Venäläinen
Sami Väänänen
Emeritus and Emerita members
Antti Aula
Jatta Berberat
Elvis Danso
Chibuzor Eneh
James Fick
Kimmo Halonen
Mari Huttu
Jarkko Iivarinen
Satu Inkinen
Erna Kaleva
Janne Karjalainen
Panu Kiviranta
Yevgeniya Kobrina
Harri Kokkonen
Mikko Laasanen
Roope Lasanen
Jukka Liukkonen
Pauno Lötjönen
Markus Malo
Katariina Nissinen
Xiaowei Ojanen
Viktória Prantner
Jari Rautiainen
Ossi Riekkinen
Ari Ronkainen
Lasse Räsänen
Elli-Noora Salo
Dmitry Semenov
Tuomo Silvast
Jani Teerijoki
Matti Timonen
Siru Turunen
Tuomas Virén
Janne Ylärinne
Research Group
Mikko
Juhani Lammi
Ph.D., Research Director
WoS ResearcherID
Tissue and cell biology
Personal information
Phone:
+358 040 5870601
Room:
Me/330
Email:
mikko.lammi[at]uef.fi (please fix the address before mailing!)
Date of birth:
29 December 1961
Current research interests:
Tissue engineering, cartilage repair, chondrogenic differentiation, biomaterials, Kashin-Beck disease
Education:
Title of Docent (Cell Biology), University of Kuopio, Kuopio, 1999
Ph.D. (biochemistry), University of Kuopio, Kuopio, 1993
M.Sc., University of Kuopio, Kuopio, 1986
Language proficiency:
Finnish, native language
English, fluent
Swedish, good
German, fairly good
Skills:
Cell Biology, tissue engineering, cartilage repair.
Hobbies:
Music, rock concerts, science fiction (Star Trek and Babylon 5)
Publications:
(full papers,
conference proceedings
)
Lammi M
, Vuolle S, Kiekara T, Kurppa K, ORCID: https://orcid.org/0000-0003-4757-2164, Pauniaho SL and ORCID: https://orcid.org/0000-0002-8212-9240.
The use of abdominal imaging studies in children visiting emergency department was variable and unsystematic.
Acta Paediatr. 2019 Nov;108(11):2089-2094. doi: 10.1111/apa.14868. Epub 2019 Jun 24.
Li W, Hirvasniemi J, Guo X, Saarakkala S,
Lammi MJ
, ORCID: http://orcid.org/0000-0002-6181-9904 and Qu C.
Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee.
Sci Rep. 2018 Nov 30;8(1):17510. doi: 10.1038/s41598-018-35552-8.
Prittinen J, Ylarinne J, Piltti J, Karhula SS, Rieppo L, Ojanen SP, Korhonen RK, Saarakkala S,
Lammi MJ
and Qu C.
Effect of centrifugal force on the development of articular neocartilage with bovine primary chondrocytes.
Cell Tissue Res. 2019 Mar;375(3):629-639. doi: 10.1007/s00441-018-2938-3. Epub 2018 Oct 23.
Lammi MJ
, ORCID: 0000-0002-6181-9904, Piltti J, ORCID: 0000-0002-1732-4269, Prittinen J, Qu C and ORCID: 0000-0002-1710-7715.
Challenges in Fabrication of Tissue-Engineered Cartilage with Correct Cellular Colonization and Extracellular Matrix Assembly.
Int J Mol Sci. 2018 Sep 11;19(9). pii: ijms19092700. doi: 10.3390/ijms19092700.
Qu C, Kaitainen S, Kroger H, Lappalainen R and
Lammi MJ
.
Behavior of Human Bone Marrow-Derived Mesenchymal Stem Cells on Various Titanium-Based Coatings.
Materials (Basel). 2016 Oct 12;9(10). pii: ma9100827. doi: 10.3390/ma9100827.
Arasu UT, Karna R, Harkonen K, Oikari S, Koistinen A, Kroger H, Qu C,
Lammi MJ
and Rilla K.
Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles.
Matrix Biol. 2017 Dec;64:54-68. doi: 10.1016/j.matbio.2017.05.001. Epub 2017 May 5.
Rieppo L, Kokkonen HT, Kulmala KA, Kovanen V,
Lammi MJ
, Toyras J and Saarakkala S.
Infrared microspectroscopic determination of collagen cross-links in articular cartilage.
J Biomed Opt. 2017 Mar 1;22(3):35007. doi: 10.1117/1.JBO.22.3.035007.
Karhula SS, Finnila MA,
Lammi MJ
, Ylarinne JH, Kauppinen S, Rieppo L, Pritzker KP, Nieminen HJ and Saarakkala S.
Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography.
PLoS One. 2017 Jan 30;12(1):e0171075. doi: 10.1371/journal.pone.0171075. eCollection 2017.
Florea C, Tanska P, Mononen ME, Qu C,
Lammi MJ
, Laasanen MS and Korhonen RK.
A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells.
Biomech Model Mechanobiol. 2017 Feb;16(1):297-311. doi: 10.1007/s10237-016-0817-y. Epub 2016 Aug 23.
Piltti J, Varjosalo M, Qu C, Hayrinen J and
Lammi MJ
.
Rho-kinase inhibitor Y-27632 increases cellular proliferation and migration in human foreskin fibroblast cells.
Proteomics. 2015 Sep;15(17):2953-65. doi: 10.1002/pmic.201400417. Epub 2015 Jun 15.
Karjalainen HM, Qu C, Leskela SS, Rilla K and
Lammi MJ
.
Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions.
Amino Acids. 2015 Mar;47(3):561-70. doi: 10.1007/s00726-014-1888-7. Epub 2014 Dec 14.
Puhakka PH, Ylarinne JH,
Lammi MJ
, Saarakkala S, Tiitu V, Kroger H, Viren T, Jurvelin JS and Toyras J.
Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds.
Phys Med Biol. 2014 Nov 7;59(21):6537-48. doi: 10.1088/0031-9155/59/21/6537. Epub 2014 Oct 13.
Fick JM, Huttu MR,
Lammi MJ
and Korhonen RK.
In vitro glycation of articular cartilage alters the biomechanical response of chondrocytes in a depth-dependent manner.
Osteoarthritis Cartilage. 2014 Oct;22(10):1410-8. doi: 10.1016/j.joca.2014.07.020.
Prittinen J, Jiang Y, Ylarinne JH, Pakkanen TA,
Lammi MJ
and Qu C.
Chondrocyte behavior on nanostructured micropillar polypropylene and polystyrene surfaces.
Mater Sci Eng C Mater Biol Appl. 2014 Oct;43:424-31. doi: 10.1016/j.msec.2014.07.045. Epub 2014 Jul 19.
Ylarinne JH, Qu C and
Lammi MJ
.
Hypertonic conditions enhance cartilage formation in scaffold-free primary chondrocyte cultures.
Cell Tissue Res. 2014 Nov;358(2):541-50. doi: 10.1007/s00441-014-1970-1. Epub 2014 Aug 9.
Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ and
Lammi MJ
.
Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease.
Osteoarthritis Cartilage. 2014 Nov;22(11):1774-83. doi: 10.1016/j.joca.2014.07.023. Epub 2014 Aug 12.
Inkinen S, Liukkonen J, Ylarinne JH, Puhakka PH,
Lammi MJ
, Viren T, Jurvelin JS and Toyras J.
Collagen and chondrocyte concentrations control ultrasound scattering in agarose scaffolds.
Ultrasound Med Biol. 2014 Sep;40(9):2162-71. doi: 10.1016/j.ultrasmedbio.2014.03.016. Epub 2014 Jun 25.
Qu C, Hirviniemi M, Tiitu V, Jurvelin JS, Toyras J and
Lammi MJ
.
Effects of Freeze-Thaw Cycle with and without Proteolysis Inhibitors and Cryopreservant on the Biochemical and Biomechanical Properties of Articular Cartilage.
Cartilage. 2014 Apr;5(2):97-106. doi: 10.1177/1947603513515998.
Qu C, Rilla K, Tammi R, Tammi M, Kroger H and
Lammi MJ
.
Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3.
Int J Biochem Cell Biol. 2014 Mar;48:45-54. doi: 10.1016/j.biocel.2013.12.016. Epub 2014 Jan 6.
Qu C, Myllymaa S, Prittinen J, Koistinen AP, Lappalainen R and
Lammi MJ
.
Osteoblast behavior on various ultra short pulsed laser deposited surface coatings.
Mater Sci Eng C Mater Biol Appl. 2013 Apr 1;33(3):1676-82. doi: 10.1016/j.msec.2012.12.078. Epub 2012 Dec 31.
Huttu M, Turunen S, Sokolinski V, Tiitu V,
Lammi M
and Korhonen RK.
Effects of medium and temperature on cellular responses in the superficial zone of hypo-osmotically challenged articular cartilage.
J Funct Biomater. 2012 Sep;3(3):544-55. doi: 10.3390/jfb3030544.
Qu C, Puttonen KA, Lindeberg H, Ruponen M, Hovatta O, Koistinaho J and
Lammi MJ
.
Chondrogenic differentiation of human pluripotent stem cells in chondrocyte co-culture.
Int J Biochem Cell Biol. 2013 Aug;45(8):1802-12. doi: 10.1016/j.biocel.2013.05.029. Epub 2013 Jun 2.
Kulmala KA, Karjalainen HM, Kokkonen HT, Tiitu V, Kovanen V,
Lammi MJ
, Jurvelin JS, Korhonen RK and Toyras J.
Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking--contribution of steric and electrostatic effects.
Med Eng Phys. 2013 Oct;35(10):1415-20. doi: 10.1016/j.medengphy.2013.03.010. Epub 2013 Apr 24.
Kaitainen S, Mahonen AJ, Lappalainen R, Kroger H,
Lammi MJ
and Qu C.
TiO2 coating promotes human mesenchymal stem cell proliferation without the loss of their capacity for chondrogenic differentiation.
Biofabrication. 2013 Jun;5(2):025009. doi: 10.1088/1758-5082/5/2/025009. Epub 2013 Apr 17.
Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS, Rieppo L, Toyras J, Silvast TS,
Lammi MJ
and Kiviranta I.
Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit.
Osteoarthritis Cartilage. 2013 Mar;21(3):481-90. doi: 10.1016/j.joca.2012.12.004. Epub 2012 Dec 17.
Kinnunen J, Kokkonen HT, Kovanen V, Hauta-Kasari M, Vahimaa P,
Lammi MJ
, Toyras J and Jurvelin JS.
Nondestructive fluorescence-based quantification of threose-induced collagen cross-linking in bovine articular cartilage.
J Biomed Opt. 2012 Sep;17(9):97003. doi: 10.1117/1.JBO.17.9.097003.
Turunen SM,
Lammi MJ
, Saarakkala S, Han SK, Herzog W, Tanska P and Korhonen RK.
The effect of collagen degradation on chondrocyte volume and morphology in bovine articular cartilage following a hypotonic challenge.
Biomech Model Mechanobiol. 2013 Jun;12(3):417-29. doi: 10.1007/s10237-012-0409-4. Epub 2012 Jun 19.
Viren T, Huang YP, Saarakkala S, Pulkkinen H, Tiitu V, Linjama A, Kiviranta I,
Lammi MJ
, Brunott A, Brommer H, Van Weeren R, Brama PA, Zheng YP, Jurvelin JS and Toyras J.
Comparison of ultrasound and optical coherence tomography techniques for evaluation of integrity of spontaneously repaired horse cartilage.
J Med Eng Technol. 2012 Apr;36(3):185-92. doi: 10.3109/03091902.2012.663054.
Qu C, Lindeberg H, Ylarinne JH and
Lammi MJ
.
Five percent oxygen tension is not beneficial for neocartilage formation in scaffold-free cell cultures.
Cell Tissue Res. 2012 Apr;348(1):109-17. doi: 10.1007/s00441-012-1366-z. Epub 2012 Mar 6.
Turunen MJ, Toyras J,
Lammi MJ
, Jurvelin JS and Korhonen RK.
Hyperosmolaric contrast agents in cartilage tomography may expose cartilage to overload-induced cell death.
J Biomech. 2012 Feb 2;45(3):497-503. doi: 10.1016/j.jbiomech.2011.11.049. Epub 2011 Dec 27.
Turunen SM,
Lammi MJ
, Saarakkala S, Koistinen A and Korhonen RK.
Hypotonic challenge modulates cell volumes differently in the superficial zone of intact articular cartilage and cartilage explant.
Biomech Model Mechanobiol. 2012 May;11(5):665-75. doi: 10.1007/s10237-011-0341-z. Epub 2011 Aug 30.
Pollanen R, Tikkanen AM,
Lammi MJ
and Lappalainen R.
The effect of loading and material on the biomechanical properties and vitality of bovine cartilage in vitro.
J Appl Biomater Biomech. 2011 Jan-Apr;9(1):47-53. doi: 10.5301/JABB.2011.6472.
Langsjo TK, Vasara AI, Hyttinen MM,
Lammi MJ
, Kaukinen A, Helminen HJ and Kiviranta I.
Quantitative analysis of collagen network structure and fibril dimensions in cartilage repair with autologous chondrocyte transplantation.
Cells Tissues Organs. 2010;192(6):351-60. doi: 10.1159/000319469. Epub 2010 Jul 26.
Pulkkinen HJ, Tiitu V, Valonen P, Jurvelin JS,
Lammi MJ
and Kiviranta I.
Engineering of cartilage in recombinant human type II collagen gel in nude mouse model in vivo.
Osteoarthritis Cartilage. 2010 Aug;18(8):1077-87. doi: 10.1016/j.joca.2010.05.004. Epub 2010 May 28.
Olkku A, Leskinen JJ,
Lammi MJ
, Hynynen K and Mahonen A.
Ultrasound-induced activation of Wnt signaling in human MG-63 osteoblastic cells.
Bone. 2010 Aug;47(2):320-30. doi: 10.1016/j.bone.2010.04.604. Epub 2010 May 7.
Viren T, Saarakkala S, Jurvelin JS, Pulkkinen HJ, Tiitu V, Valonen P, Kiviranta I,
Lammi MJ
and Toyras J.
Quantitative evaluation of spontaneously and surgically repaired rabbit articular cartilage using intra-articular ultrasound method in situ.
Ultrasound Med Biol. 2010 May;36(5):833-9. doi: 10.1016/j.ultrasmedbio.2010.02.015.
Myllymaa S, Myllymaa K, Korhonen H,
Lammi MJ
, Tiitu V and Lappalainen R.
Surface characterization and in vitro biocompatibility assessment of photosensitive polyimide films.
Colloids Surf B Biointerfaces. 2010 Apr 1;76(2):505-11. doi: 10.1016/j.colsurfb.2009.12.011. Epub 2009 Dec 22.
Rieppo L, Saarakkala S, Narhi T, Holopainen J,
Lammi M
, Helminen HJ, Jurvelin JS and Rieppo J.
Quantitative analysis of spatial proteoglycan content in articular cartilage with Fourier transform infrared imaging spectroscopy: Critical evaluation of analysis methods and specificity of the parameters.
Microsc Res Tech. 2010 May;73(5):503-12. doi: 10.1002/jemt.20789.
Julkunen P, Harjula T, Iivarinen J, Marjanen J, Seppanen K, Narhi T, Arokoski J,
Lammi MJ
, Brama PA, Jurvelin JS and Helminen HJ.
Biomechanical, biochemical and structural correlations in immature and mature rabbit articular cartilage.
Osteoarthritis Cartilage. 2009 Dec;17(12):1628-38. doi: 10.1016/j.joca.2009.07.002. Epub 2009 Jul 8.
Myllymaa K, Myllymaa S, Korhonen H,
Lammi MJ
, Saarenpaa H, Suvanto M, Pakkanen TA, Tiitu V and Lappalainen R.
Improved adherence and spreading of Saos-2 cells on polypropylene surfaces achieved by surface texturing and carbon nitride coating.
J Mater Sci Mater Med. 2009 Nov;20(11):2337-47. doi: 10.1007/s10856-009-3792-3. Epub 2009 Jun 9.
Qu CJ, Poytakangas T, Jauhiainen M, Auriola S and
Lammi MJ
.
Glucosamine sulphate does not increase extracellular matrix production at low oxygen tension.
Cell Tissue Res. 2009 Jul;337(1):103-11. doi: 10.1007/s00441-009-0797-7. Epub 2009 May 14.
Lotjonen P, Julkunen P, Toyras J,
Lammi MJ
, Jurvelin JS and Nieminen HJ.
Strain-dependent modulation of ultrasound speed in articular cartilage under dynamic compression.
Ultrasound Med Biol. 2009 Jul;35(7):1177-84. doi: 10.1016/j.ultrasmedbio.2009.03.002. Epub 2009 May 7.
Pulkkinen HJ, Tiitu V, Valonen P, Hamalainen ER,
Lammi MJ
and Kiviranta I.
Recombinant human type II collagen as a material for cartilage tissue engineering.
Int J Artif Organs. 2008 Nov;31(11):960-9. doi: 10.1177/039139880803101106.
Tiitu V, Pulkkinen HJ, Valonen P, Kiviranta O, Kiekara T, Kiviranta I and
Lammi MJ
.
Recombinant human collagens as scaffold materials for chondrocyte cultures.
Biomed Mater Eng. 2008;18(4-5):225-9.
Silvast TS, Jurvelin JS, Aula AS,
Lammi MJ
and Toyras J.
Contrast agent-enhanced computed tomography of articular cartilage: association with tissue composition and properties.
Acta Radiol. 2009 Jan;50(1):78-85. doi: 10.1080/02841850802572526.
Tiitu V, Pulkkinen HJ, Valonen P, Pulliainen O, Kellomaki M,
Lammi MJ
and Kiviranta I.
Bioreactor improves the growth and viability of chondrocytes in the knitted poly-L,D-lactide scaffold.
Biorheology. 2008;45(3-4):539-46.
Leskinen JJ, Karjalainen HM, Olkku A, Hynynen K, Mahonen A and
Lammi MJ
.
Genome-wide microarray analysis of MG-63 osteoblastic cells exposed to ultrasound.
Biorheology. 2008;45(3-4):345-54.
Piltti J, Hayrinen J, Karjalainen HM and
Lammi MJ
.
Proteomics of chondrocytes with special reference to phosphorylation changes of proteins in stretched human chondrosarcoma cells.
Biorheology. 2008;45(3-4):323-35.
Silvast TS, Jurvelin JS,
Lammi MJ
and Toyras J.
pQCT study on diffusion and equilibrium distribution of iodinated anionic contrast agent in human articular cartilage--associations to matrix composition and integrity.
Osteoarthritis Cartilage. 2009 Jan;17(1):26-32. doi: 10.1016/j.joca.2008.05.012. Epub 2008 Jul 7.
Julkunen P, Wilson W, Jurvelin JS, Rieppo J, Qu CJ,
Lammi MJ
and Korhonen RK.
Stress-relaxation of human patellar articular cartilage in unconfined compression: prediction of mechanical response by tissue composition and structure.
J Biomech. 2008;41(9):1978-86. doi: 10.1016/j.jbiomech.2008.03.026. Epub 2008 May 19.
Contact: +358 29 4451111 (Switch), email:
bbc-l [at] lists.uef.fi