Research Group

Rami Kristian Korhonen

Professor, Co-head of the BBC group
University of Eastern Finland

Personal information

  • Phone: +358 04 3553260
  • Room: Sn/3131/2
  • Email: rami.korhonen [at] uef.fi (please fix the address before mailing!)

  • Date of birth: 22 November 1975

  • Current research interests: Biomechanical modeling of articular cartilage: collagen viscoelasticity, compression-tension nonlinearity; chondrocyte mechanics using experimental and theoretical approaches; modeling of total hip replacement prostheses; confocal scanning microscopic imaging of chondrocytes; magnetic resonance imaging of cartilage; diagnostics of osteoarthritis

  • Previous research experience: Assistant Researcher 6 months, Assistant Physicist 17 months, Project Researcher 17 months, Researcher 13 months, Post Doctoral Researcher 3 years, Academy Research Fellow 5 years, Assistant Professor 3 years

  • Education: MSc 2000 (Medical Physics), University of Kuopio; PhD 2004 (Physics), University of Kuopio.

  • Most important foreign visits: Dr. Walter Herzog's group, University of Calgary, Canada, September 2005 - November 2007

  • Skills: Finite element software Abaqus, Matlab programming, Modeling of material characteristics

  • Hobbies: Gym, football, badminton, bandy, tennis

  • Awards:
    • The Perkins Prize 2003: for best paper published in Medical Engineering & Physics in 2002.
    • Finalist in the CSB2006 (Canadian Society for Biomechanics) NDI Young Investigator Award Open Category Competition.

  • Reviews for scientific journals
    • Journal of Biomechanics
    • Journal of Biomechanical Engineering
    • Arthritis & Rheumatism
    • Proceedings of the Royal Society A
    • Acta Orthopaedica
    • Acta Biomaterialia
    • Medical Engineering & Physics
    • Biomechanics and Modeling in Mechanobiology
    • Physiological Measurement
    • Microfluidics and Nanofluidics
    • Osteoarthritis and Cartilage
    • Journal of Orthopedic Research
    • Computer Methods and Programs in Biomedicine
    • etc.

Latest 50 publications:

  1. Afara IO, ORCID: http://orcid.org/0000-0001-7114-0439, Florea C, Olumegbon IA, Eneh CT, Malo MKH, ORCID: http://orcid.org/0000-0002-2617-1129, Korhonen RK and Toyras J. Characterizing human subchondral bone properties using near-infrared (NIR) spectroscopy. Sci Rep. 2018 Jun 27;8(1):9733. doi: 10.1038/s41598-018-27786-3.

  2. Ojanen SP, ORCID: 0000-0003-4386-0716, Finnila MAJ, Reunamo AE, Ronkainen AP, Mikkonen S, Herzog W, Saarakkala S and Korhonen RK. Site-specific glycosaminoglycan content is better maintained in the pericellular matrix than the extracellular matrix in early post-traumatic osteoarthritis. PLoS One. 2018 Apr 25;13(4):e0196203. doi: 10.1371/journal.pone.0196203.

  3. Orozco GA, Tanska P, Mononen ME, Halonen KS and Korhonen RK. The effect of constitutive representations and structural constituents of ligaments on knee joint mechanics. Sci Rep. 2018 Feb 2;8(1):2323. doi: 10.1038/s41598-018-20739-w.

  4. Makela JTA, Cooper BG, Korhonen RK, Grinstaff MW and Snyder BD. Functional effects of an interpenetrating polymer network on articular cartilage mechanical properties. Osteoarthritis Cartilage. 2018 Mar;26(3):414-421. doi:

  5. Klets O, ORCID: http://orcid.org/0000-0002-7117-3465, Mononen ME, Liukkonen MK, Nevalainen MT, Nieminen MT, Saarakkala S and Korhonen RK. Estimation of the Effect of Body Weight on the Development of Osteoarthritis Based on Cumulative Stresses in Cartilage: Data from the Osteoarthritis Initiative. Ann Biomed Eng. 2018 Feb;46(2):334-344. doi: 10.1007/s10439-017-1974-6. Epub 2017

  6. Ala-Myllymaki J, Danso EK, Honkanen JTJ, Korhonen RK, Toyras J and Afara IO. Optical spectroscopic characterization of human meniscus biomechanical properties. J Biomed Opt. 2017 Dec;22(12):1-10. doi: 10.1117/1.JBO.22.12.125008.

  7. Tanska P, ORCID: http://orcid.org/0000-0002-9684-6902, Julkunen P and Korhonen RK. A computational algorithm to simulate disorganization of collagen network in injured articular cartilage. Biomech Model Mechanobiol. 2018 Jun;17(3):689-699. doi:

  8. Mononen ME, Tanska P, Isaksson H and Korhonen RK. New algorithm for simulation of proteoglycan loss and collagen degeneration in the knee joint: Data from the osteoarthritis initiative. J Orthop Res. 2018 Jun;36(6):1673-1683. doi: 10.1002/jor.23811. Epub 2017 Dec 19.

  9. Ojanen X, Tanska P, Malo MKH, Isaksson H, Vaananen SP, Koistinen AP, Grassi L, Magnusson SP, Ribel-Madsen SM, Korhonen RK, Jurvelin JS and Toyras J. Tissue viscoelasticity is related to tissue composition but may not fully predict the apparent-level viscoelasticity in human trabecular bone - An experimental and finite element study. J Biomech. 2017 Dec 8;65:96-105. doi: 10.1016/j.jbiomech.2017.10.002. Epub 2017

  10. Liukkonen MK, Mononen ME, Vartiainen P, Kaukinen P, Bragge T, Suomalainen JS, Malo MKH, Venesmaa S, Kakela P, Pihlajamaki J, Karjalainen PA, Arokoski JP and Korhonen RK. Evaluation of the Effect of Bariatric Surgery-Induced Weight Loss on Knee Gait and Cartilage Degeneration. J Biomech Eng. 2018 Apr 1;140(4). pii: 2662611. doi: 10.1115/1.4038330.

  11. Liukkonen MK, Mononen ME, Tanska P, Saarakkala S, Nieminen MT and Korhonen RK. Application of a semi-automatic cartilage segmentation method for biomechanical modeling of the knee joint. Comput Methods Biomech Biomed Engin. 2017 Oct;20(13):1453-1463. doi:

  12. Liukkonen MK, Mononen ME, Klets O, Arokoski JP, Saarakkala S and Korhonen RK. Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative. Sci Rep. 2017 Aug 23;7(1):9177. doi: 10.1038/s41598-017-09013-7.

  13. Rasanen LP, Tanska P, Zbyn S, van Donkelaar CC, Trattnig S, Nieminen MT and Korhonen RK. The effect of fixed charge density and cartilage swelling on mechanics of knee joint cartilage during simulated gait. J Biomech. 2017 Aug 16;61:34-44. doi: 10.1016/j.jbiomech.2017.06.041. Epub 2017

  14. Han SK, Ronkainen AP, Saarakkala S, Rieppo L, ORCID: http://orcid.org/0000-0001-5542-4060, Herzog W and Korhonen RK. Alterations in structural macromolecules and chondrocyte deformations in lapine retropatellar cartilage 9 weeks after anterior cruciate ligament transection. J Orthop Res. 2018 Jan;36(1):342-350. doi: 10.1002/jor.23650. Epub 2017 Jul 31.

  15. Viren T, Honkanen JT, Danso EK, Rieppo L, Korhonen RK and Toyras J. Ultrasound Assessment of Human Meniscus. Ultrasound Med Biol. 2017 Sep;43(9):1753-1763. doi:

  16. Danso EK, Oinas JMT, Saarakkala S, Mikkonen S, Toyras J and Korhonen RK. Structure-function relationships of human meniscus. J Mech Behav Biomed Mater. 2017 Mar;67:51-60. doi: 10.1016/j.jmbbm.2016.12.002.

  17. Venalainen MS, Mononen ME, Salo J, Rasanen LP, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Quantitative Evaluation of the Mechanical Risks Caused by Focal Cartilage Defects in the Knee. Sci Rep. 2016 Nov 29;6:37538. doi: 10.1038/srep37538.

  18. Fick JM, P Ronkainen A, Madden R, Sawatsky A, Tiitu V, Herzog W and Korhonen RK. Early in situ changes in chondrocyte biomechanical responses due to a partial meniscectomy in the lateral compartment of the mature rabbit knee joint. J Biomech. 2016 Dec 8;49(16):4057-4064. doi: 10.1016/j.jbiomech.2016.10.039. Epub

  19. Klets O, Mononen ME, Tanska P, Nieminen MT, Korhonen RK and Saarakkala S. Comparison of different material models of articular cartilage in 3D computational modeling of the knee: Data from the Osteoarthritis Initiative (OAI). J Biomech. 2016 Dec 8;49(16):3891-3900. doi: 10.1016/j.jbiomech.2016.10.025. Epub

  20. Rasanen LP, Tanska P, Mononen ME, Lammentausta E, Zbyn S, Venalainen MS, Szomolanyi P, van Donkelaar CC, Jurvelin JS, Trattnig S, Nieminen MT and Korhonen RK. Spatial variation of fixed charge density in knee joint cartilage from sodium MRI - Implication on knee joint mechanics under static loading. J Biomech. 2016 Oct 3;49(14):3387-3396. doi: 10.1016/j.jbiomech.2016.09.011. Epub

  21. Florea C, Tanska P, Mononen ME, Qu C, Lammi MJ, Laasanen MS and Korhonen RK. A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells. Biomech Model Mechanobiol. 2017 Feb;16(1):297-311. doi:

  22. Ronkainen AP, Fick JM, Herzog W and Korhonen RK. Site-specific cell-tissue interactions in rabbit knee joint articular cartilage. J Biomech. 2016 Sep 6;49(13):2882-2890. doi: 10.1016/j.jbiomech.2016.06.033. Epub

  23. Halonen KS, Mononen ME, Toyras J, Kroger H, Joukainen A and Korhonen RK. Optimal graft stiffness and pre-strain restore normal joint motion and cartilage responses in ACL reconstructed knee. J Biomech. 2016 Sep 6;49(13):2566-2576. doi: 10.1016/j.jbiomech.2016.05.002. Epub

  24. Puhakka PH, Te Moller NC, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound. Acta Orthop. 2016 Aug;87(4):418-24. doi: 10.1080/17453674.2016.1180578. Epub 2016

  25. Halonen KS, Mononen ME, Jurvelin JS, Toyras J, Klodowski A, Kulmala JP and Korhonen RK. Importance of Patella, Quadriceps Forces, and Depthwise Cartilage Structure on Knee Joint Motion and Cartilage Response During Gait. J Biomech Eng. 2016 Jul 1;138(7). pii: 2520868. doi: 10.1115/1.4033516.

  26. Makela JTA and Korhonen RK. Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity. J Biomech. 2016 Jun 14;49(9):1734-1741. doi: 10.1016/j.jbiomech.2016.04.002. Epub

  27. Venalainen MS, Mononen ME, Vaananen SP, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Effect of bone inhomogeneity on tibiofemoral contact mechanics during physiological loading. J Biomech. 2016 May 3;49(7):1111-1120. doi: 10.1016/j.jbiomech.2016.02.033. Epub

  28. Mononen ME, Tanska P, Isaksson H and Korhonen RK. A Novel Method to Simulate the Progression of Collagen Degeneration of Cartilage in the Knee: Data from the Osteoarthritis Initiative. Sci Rep. 2016 Feb 24;6:21415. doi: 10.1038/srep21415.

  29. Rasanen LP, Mononen ME, Lammentausta E, Nieminen MT, Jurvelin JS and Korhonen RK. Three dimensional patient-specific collagen architecture modulates cartilage responses in the knee joint during gait. Comput Methods Biomech Biomed Engin. 2016;19(11):1225-40. doi:

  30. Fick JM, Ronkainen A, Herzog W and Korhonen RK. Site-dependent biomechanical responses of chondrocytes in the rabbit knee joint. J Biomech. 2015 Nov 26;48(15):4010-9. doi: 10.1016/j.jbiomech.2015.09.049. Epub

  31. Iivarinen JT, Korhonen RK and Jurvelin JS. Modeling of interstitial fluid movement in soft tissue under negative pressure--relevance to treatment of tissue swelling. Comput Methods Biomech Biomed Engin. 2016;19(10):1089-98. doi:

  32. Hirvasniemi J, Thevenot J, Kokkonen HT, Finnila MA, Venalainen MS, Jamsa T, Korhonen RK, Toyras J and Saarakkala S. Correlation of Subchondral Bone Density and Structure from Plain Radiographs with Micro Computed Tomography Ex Vivo. Ann Biomed Eng. 2016 May;44(5):1698-709. doi: 10.1007/s10439-015-1452-y. Epub

  33. Makela JT, Han SK, Herzog W and Korhonen RK. Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage. J Biomech. 2015 Sep 18;48(12):3369-76. doi: 10.1016/j.jbiomech.2015.06.010. Epub

  34. Puhakka PH, Te Moller NCR, Afara IO, Makela JTA, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. Osteoarthritis Cartilage. 2015 Dec;23(12):2206-2213. doi:

  35. Korhonen RK, Tanska P, Kaartinen SM, Fick JM and Mononen ME. New Concept to Restore Normal Cell Responses in Osteoarthritic Knee Joint Cartilage. Exerc Sport Sci Rev. 2015 Jul;43(3):143-52. doi: 10.1249/JES.0000000000000051.

  36. Honkanen JT, Danso EK, Suomalainen JS, Tiitu V, Korhonen RK, Jurvelin JS and Toyras J. Contrast enhanced imaging of human meniscus using cone beam CT. Osteoarthritis Cartilage. 2015 Aug;23(8):1367-76. doi:

  37. Arokoski ME, Tiitu V, Jurvelin JS, Korhonen RK and Fick JM. Topographical investigation of changes in depth-wise proteoglycan distribution in rabbit femoral articular cartilage at 4 weeks after transection of the anterior cruciate ligament. J Orthop Res. 2015 Sep;33(9):1278-86. doi: 10.1002/jor.22906. Epub 2015 May 21.

  38. Tanska P, Mononen ME and Korhonen RK. A multi-scale finite element model for investigation of chondrocyte mechanics in normal and medial meniscectomy human knee joint during walking. J Biomech. 2015 Jun 1;48(8):1397-406. doi: 10.1016/j.jbiomech.2015.02.043. Epub

  39. Danso EK, Makela JT, Tanska P, Mononen ME, Honkanen JT, Jurvelin JS, Toyras J, Julkunen P and Korhonen RK. Characterization of site-specific biomechanical properties of human meniscus-Importance of collagen and fluid on mechanical nonlinearities. J Biomech. 2015 Jun 1;48(8):1499-507. doi: 10.1016/j.jbiomech.2015.01.048. Epub

  40. Florea C, Malo MK, Rautiainen J, Makela JT, Fick JM, Nieminen MT, Jurvelin JS, Davidescu A and Korhonen RK. Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2015 Mar;23(3):414-22. doi: 10.1016/j.joca.2014.11.023.

  41. Venalainen MS, Mononen ME, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Importance of material properties and porosity of bone on mechanical response of articular cartilage in human knee joint--a two-dimensional finite element study. J Biomech Eng. 2014 Dec;136(12):121005. doi: 10.1115/1.4028801.

  42. Rautiainen J, Nissi MJ, Liimatainen T, Herzog W, Korhonen RK and Nieminen MT. Adiabatic rotating frame relaxation of MRI reveals early cartilage degeneration in a rabbit model of anterior cruciate ligament transection. Osteoarthritis Cartilage. 2014 Oct;22(10):1444-52. doi:

  43. Fick JM, Huttu MR, Lammi MJ and Korhonen RK. In vitro glycation of articular cartilage alters the biomechanical response of chondrocytes in a depth-dependent manner. Osteoarthritis Cartilage. 2014 Oct;22(10):1410-8. doi:

  44. Halonen KS, Mononen ME, Jurvelin JS, Toyras J, Salo J and Korhonen RK. Deformation of articular cartilage during static loading of a knee joint--experimental and finite element analysis. J Biomech. 2014 Jul 18;47(10):2467-74. doi: 10.1016/j.jbiomech.2014.04.013. Epub

  45. Makela JT, Rezaeian ZS, Mikkonen S, Madden R, Han SK, Jurvelin JS, Herzog W and Korhonen RK. Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2014 Jun;22(6):869-78. doi: 10.1016/j.joca.2014.04.010.

  46. Huttu MR, Puhakka J, Makela JT, Takakubo Y, Tiitu V, Saarakkala S, Konttinen YT, Kiviranta I and Korhonen RK. Cell-tissue interactions in osteoarthritic human hip joint articular cartilage. Connect Tissue Res. 2014 Aug;55(4):282-91. doi: 10.3109/03008207.2014.912645.

  47. Iivarinen JT, Korhonen RK and Jurvelin JS. Experimental and numerical analysis of soft tissue stiffness measurement using manual indentation device--significance of indentation geometry and soft tissue thickness. Skin Res Technol. 2014 Aug;20(3):347-54. doi: 10.1111/srt.12125. Epub 2013 Nov

  48. Danso EK, Honkanen JT, Saarakkala S and Korhonen RK. Comparison of nonlinear mechanical properties of bovine articular cartilage and meniscus. J Biomech. 2014 Jan 3;47(1):200-6. doi: 10.1016/j.jbiomech.2013.09.015. Epub 2013

  49. Huttu M, Turunen S, Sokolinski V, Tiitu V, Lammi M and Korhonen RK. Effects of medium and temperature on cellular responses in the superficial zone of hypo-osmotically challenged articular cartilage. J Funct Biomater. 2012 Sep;3(3):544-55. doi: 10.3390/jfb3030544.

  50. Korhonen RK, Julkunen P, Li L and van Donkelaar CC. Computational models of articular cartilage. Comput Math Methods Med. 2013;2013:254507. doi: 10.1155/2013/254507. Epub 2013

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