Research Group

Rami Kristian Korhonen

Professor, Co-head of the BBC group
University of Eastern Finland

Personal information

  • Phone: +358 04 3553260
  • Room: Sn/3131/2
  • Email: rami.korhonen [at] uef.fi (please fix the address before mailing!)

  • Date of birth: 22 November 1975

  • Current research interests: Biomechanical modeling of articular cartilage: collagen viscoelasticity, compression-tension nonlinearity; chondrocyte mechanics using experimental and theoretical approaches; modeling of total hip replacement prostheses; confocal scanning microscopic imaging of chondrocytes; magnetic resonance imaging of cartilage; diagnostics of osteoarthritis

  • Previous research experience: Assistant Researcher 6 months, Assistant Physicist 17 months, Project Researcher 17 months, Researcher 13 months, Post Doctoral Researcher 3 years, Academy Research Fellow 5 years, Assistant Professor 3 years

  • Education: MSc 2000 (Medical Physics), University of Kuopio; PhD 2004 (Physics), University of Kuopio.

  • Most important foreign visits: Dr. Walter Herzog's group, University of Calgary, Canada, September 2005 - November 2007

  • Skills: Finite element software Abaqus, Matlab programming, Modeling of material characteristics

  • Hobbies: Gym, football, badminton, bandy, tennis

  • Awards:
    • The Perkins Prize 2003: for best paper published in Medical Engineering & Physics in 2002.
    • Finalist in the CSB2006 (Canadian Society for Biomechanics) NDI Young Investigator Award Open Category Competition.

  • Reviews for scientific journals
    • Journal of Biomechanics
    • Journal of Biomechanical Engineering
    • Arthritis & Rheumatism
    • Proceedings of the Royal Society A
    • Acta Orthopaedica
    • Acta Biomaterialia
    • Medical Engineering & Physics
    • Biomechanics and Modeling in Mechanobiology
    • Physiological Measurement
    • Microfluidics and Nanofluidics
    • Osteoarthritis and Cartilage
    • Journal of Orthopedic Research
    • Computer Methods and Programs in Biomedicine
    • etc.

Latest 50 publications:

  1. Ojanen X, Tanska P, Malo MKH, Isaksson H, Vaananen SP, Koistinen AP, Grassi L, Magnusson SP, Ribel-Madsen SM, Korhonen RK, Jurvelin JS and Toyras J. Tissue viscoelasticity is related to tissue composition but may not fully predict the apparent-level viscoelasticity in human trabecular bone - An experimental and finite element study. J Biomech. 2017 Oct 13. pii: S0021-9290(17)30516-X. doi:

  2. Liukkonen MK, Mononen ME, Tanska P, Saarakkala S, Nieminen MT and Korhonen RK. Application of a semi-automatic cartilage segmentation method for biomechanical modeling of the knee joint. Comput Methods Biomech Biomed Engin. 2017 Oct;20(13):1453-1463. doi:

  3. Liukkonen MK, Mononen ME, Klets O, Arokoski JP, Saarakkala S and Korhonen RK. Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data: Data from the Osteoarthritis Initiative. Sci Rep. 2017 Aug 23;7(1):9177. doi: 10.1038/s41598-017-09013-7.

  4. Rasanen LP, Tanska P, Zbyn S, van Donkelaar CC, Trattnig S, Nieminen MT and Korhonen RK. The effect of fixed charge density and cartilage swelling on mechanics of knee joint cartilage during simulated gait. J Biomech. 2017 Aug 16;61:34-44. doi: 10.1016/j.jbiomech.2017.06.041. Epub 2017

  5. Han SK, Ronkainen AP, Saarakkala S, Rieppo L, ORCID: http://orcid.org/0000-0001-5542-4060, Herzog W and Korhonen RK. Alterations in structural macromolecules and chondrocyte deformations in lapine retropatellar cartilage 9 weeks after anterior cruciate ligament transection. J Orthop Res. 2017 Jul 8. doi: 10.1002/jor.23650.

  6. Viren T, Honkanen JT, Danso EK, Rieppo L, Korhonen RK and Toyras J. Ultrasound Assessment of Human Meniscus. Ultrasound Med Biol. 2017 Sep;43(9):1753-1763. doi:

  7. Danso EK, Oinas JM, Saarakkala S, Mikkonen S, Toyras J and Korhonen RK. Structure-function relationships of human meniscus. J Mech Behav Biomed Mater. 2017 Mar;67:51-60. doi: 10.1016/j.jmbbm.2016.12.002.

  8. Venalainen MS, Mononen ME, Salo J, Rasanen LP, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Quantitative Evaluation of the Mechanical Risks Caused by Focal Cartilage Defects in the Knee. Sci Rep. 2016 Nov 29;6:37538. doi: 10.1038/srep37538.

  9. Fick JM, P Ronkainen A, Madden R, Sawatsky A, Tiitu V, Herzog W and Korhonen RK. Early in situ changes in chondrocyte biomechanical responses due to a partial meniscectomy in the lateral compartment of the mature rabbit knee joint. J Biomech. 2016 Dec 8;49(16):4057-4064. doi: 10.1016/j.jbiomech.2016.10.039. Epub

  10. Klets O, Mononen ME, Tanska P, Nieminen MT, Korhonen RK and Saarakkala S. Comparison of different material models of articular cartilage in 3D computational modeling of the knee: Data from the Osteoarthritis Initiative (OAI). J Biomech. 2016 Dec 8;49(16):3891-3900. doi: 10.1016/j.jbiomech.2016.10.025. Epub

  11. Rasanen LP, Tanska P, Mononen ME, Lammentausta E, Zbyn S, Venalainen MS, Szomolanyi P, van Donkelaar CC, Jurvelin JS, Trattnig S, Nieminen MT and Korhonen RK. Spatial variation of fixed charge density in knee joint cartilage from sodium MRI - Implication on knee joint mechanics under static loading. J Biomech. 2016 Oct 3;49(14):3387-3396. doi: 10.1016/j.jbiomech.2016.09.011. Epub

  12. Florea C, Tanska P, Mononen ME, Qu C, Lammi MJ, Laasanen MS and Korhonen RK. A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells. Biomech Model Mechanobiol. 2017 Feb;16(1):297-311. doi:

  13. Ronkainen AP, Fick JM, Herzog W and Korhonen RK. Site-specific cell-tissue interactions in rabbit knee joint articular cartilage. J Biomech. 2016 Sep 6;49(13):2882-2890. doi: 10.1016/j.jbiomech.2016.06.033. Epub

  14. Halonen KS, Mononen ME, Toyras J, Kroger H, Joukainen A and Korhonen RK. Optimal graft stiffness and pre-strain restore normal joint motion and cartilage responses in ACL reconstructed knee. J Biomech. 2016 Sep 6;49(13):2566-2576. doi: 10.1016/j.jbiomech.2016.05.002. Epub

  15. Puhakka PH, Te Moller NC, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Optical coherence tomography enables accurate measurement of equine cartilage thickness for determination of speed of sound. Acta Orthop. 2016 Aug;87(4):418-24. doi: 10.1080/17453674.2016.1180578. Epub 2016

  16. Halonen KS, Mononen ME, Jurvelin JS, Toyras J, Klodowski A, Kulmala JP and Korhonen RK. Importance of Patella, Quadriceps Forces, and Depthwise Cartilage Structure on Knee Joint Motion and Cartilage Response During Gait. J Biomech Eng. 2016 Jul 1;138(7). doi: 10.1115/1.4033516.

  17. Makela JTA and Korhonen RK. Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity. J Biomech. 2016 Jun 14;49(9):1734-1741. doi: 10.1016/j.jbiomech.2016.04.002. Epub

  18. Venalainen MS, Mononen ME, Vaananen SP, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Effect of bone inhomogeneity on tibiofemoral contact mechanics during physiological loading. J Biomech. 2016 May 3;49(7):1111-1120. doi: 10.1016/j.jbiomech.2016.02.033. Epub

  19. Mononen ME, Tanska P, Isaksson H and Korhonen RK. A Novel Method to Simulate the Progression of Collagen Degeneration of Cartilage in the Knee: Data from the Osteoarthritis Initiative. Sci Rep. 2016 Feb 24;6:21415. doi: 10.1038/srep21415.

  20. Rasanen LP, Mononen ME, Lammentausta E, Nieminen MT, Jurvelin JS and Korhonen RK. Three dimensional patient-specific collagen architecture modulates cartilage responses in the knee joint during gait. Comput Methods Biomech Biomed Engin. 2016;19(11):1225-40. doi:

  21. Fick JM, Ronkainen A, Herzog W and Korhonen RK. Site-dependent biomechanical responses of chondrocytes in the rabbit knee joint. J Biomech. 2015 Nov 26;48(15):4010-9. doi: 10.1016/j.jbiomech.2015.09.049. Epub

  22. Iivarinen JT, Korhonen RK and Jurvelin JS. Modeling of interstitial fluid movement in soft tissue under negative pressure--relevance to treatment of tissue swelling. Comput Methods Biomech Biomed Engin. 2016;19(10):1089-98. doi:

  23. Hirvasniemi J, Thevenot J, Kokkonen HT, Finnila MA, Venalainen MS, Jamsa T, Korhonen RK, Toyras J and Saarakkala S. Correlation of Subchondral Bone Density and Structure from Plain Radiographs with Micro Computed Tomography Ex Vivo. Ann Biomed Eng. 2016 May;44(5):1698-709. doi: 10.1007/s10439-015-1452-y. Epub

  24. Makela JT, Han SK, Herzog W and Korhonen RK. Very early osteoarthritis changes sensitively fluid flow properties of articular cartilage. J Biomech. 2015 Sep 18;48(12):3369-76. doi: 10.1016/j.jbiomech.2015.06.010. Epub

  25. Puhakka PH, Te Moller NCR, Afara IO, Makela JTA, Tiitu V, Korhonen RK, Brommer H, Viren T, Jurvelin JS and Toyras J. Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal. Osteoarthritis Cartilage. 2015 Dec;23(12):2206-2213. doi:

  26. Korhonen RK, Tanska P, Kaartinen SM, Fick JM and Mononen ME. New Concept to Restore Normal Cell Responses in Osteoarthritic Knee Joint Cartilage. Exerc Sport Sci Rev. 2015 Jul;43(3):143-52. doi: 10.1249/JES.0000000000000051.

  27. Honkanen JT, Danso EK, Suomalainen JS, Tiitu V, Korhonen RK, Jurvelin JS and Toyras J. Contrast enhanced imaging of human meniscus using cone beam CT. Osteoarthritis Cartilage. 2015 Aug;23(8):1367-76. doi:

  28. Arokoski ME, Tiitu V, Jurvelin JS, Korhonen RK and Fick JM. Topographical investigation of changes in depth-wise proteoglycan distribution in rabbit femoral articular cartilage at 4 weeks after transection of the anterior cruciate ligament. J Orthop Res. 2015 Sep;33(9):1278-86. doi: 10.1002/jor.22906. Epub 2015 May 21.

  29. Tanska P, Mononen ME and Korhonen RK. A multi-scale finite element model for investigation of chondrocyte mechanics in normal and medial meniscectomy human knee joint during walking. J Biomech. 2015 Jun 1;48(8):1397-406. doi: 10.1016/j.jbiomech.2015.02.043. Epub

  30. Danso EK, Makela JT, Tanska P, Mononen ME, Honkanen JT, Jurvelin JS, Toyras J, Julkunen P and Korhonen RK. Characterization of site-specific biomechanical properties of human meniscus-Importance of collagen and fluid on mechanical nonlinearities. J Biomech. 2015 Jun 1;48(8):1499-507. doi: 10.1016/j.jbiomech.2015.01.048. Epub

  31. Florea C, Malo MK, Rautiainen J, Makela JT, Fick JM, Nieminen MT, Jurvelin JS, Davidescu A and Korhonen RK. Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2015 Mar;23(3):414-22. doi: 10.1016/j.joca.2014.11.023.

  32. Venalainen MS, Mononen ME, Jurvelin JS, Toyras J, Viren T and Korhonen RK. Importance of material properties and porosity of bone on mechanical response of articular cartilage in human knee joint--a two-dimensional finite element study. J Biomech Eng. 2014 Dec;136(12):121005. doi: 10.1115/1.4028801.

  33. Rautiainen J, Nissi MJ, Liimatainen T, Herzog W, Korhonen RK and Nieminen MT. Adiabatic rotating frame relaxation of MRI reveals early cartilage degeneration in a rabbit model of anterior cruciate ligament transection. Osteoarthritis Cartilage. 2014 Oct;22(10):1444-52. doi:

  34. Fick JM, Huttu MR, Lammi MJ and Korhonen RK. In vitro glycation of articular cartilage alters the biomechanical response of chondrocytes in a depth-dependent manner. Osteoarthritis Cartilage. 2014 Oct;22(10):1410-8. doi:

  35. Halonen KS, Mononen ME, Jurvelin JS, Toyras J, Salo J and Korhonen RK. Deformation of articular cartilage during static loading of a knee joint--experimental and finite element analysis. J Biomech. 2014 Jul 18;47(10):2467-74. doi: 10.1016/j.jbiomech.2014.04.013. Epub

  36. Makela JT, Rezaeian ZS, Mikkonen S, Madden R, Han SK, Jurvelin JS, Herzog W and Korhonen RK. Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2014 Jun;22(6):869-78. doi: 10.1016/j.joca.2014.04.010.

  37. Huttu MR, Puhakka J, Makela JT, Takakubo Y, Tiitu V, Saarakkala S, Konttinen YT, Kiviranta I and Korhonen RK. Cell-tissue interactions in osteoarthritic human hip joint articular cartilage. Connect Tissue Res. 2014 Aug;55(4):282-91. doi: 10.3109/03008207.2014.912645.

  38. Iivarinen JT, Korhonen RK and Jurvelin JS. Experimental and numerical analysis of soft tissue stiffness measurement using manual indentation device--significance of indentation geometry and soft tissue thickness. Skin Res Technol. 2014 Aug;20(3):347-54. doi: 10.1111/srt.12125. Epub 2013 Nov

  39. Danso EK, Honkanen JT, Saarakkala S and Korhonen RK. Comparison of nonlinear mechanical properties of bovine articular cartilage and meniscus. J Biomech. 2014 Jan 3;47(1):200-6. doi: 10.1016/j.jbiomech.2013.09.015. Epub 2013

  40. Huttu M, Turunen S, Sokolinski V, Tiitu V, Lammi M and Korhonen RK. Effects of medium and temperature on cellular responses in the superficial zone of hypo-osmotically challenged articular cartilage. J Funct Biomater. 2012 Sep;3(3):544-55. doi: 10.3390/jfb3030544.

  41. Korhonen RK, Julkunen P, Li L and van Donkelaar CC. Computational models of articular cartilage. Comput Math Methods Med. 2013;2013:254507. doi: 10.1155/2013/254507. Epub 2013

  42. Julkunen P, Wilson W, Isaksson H, Jurvelin JS, Herzog W and Korhonen RK. A review of the combination of experimental measurements and fibril-reinforced modeling for investigation of articular cartilage and chondrocyte response to loading. Comput Math Methods Med. 2013;2013:326150. doi: 10.1155/2013/326150. Epub 2013

  43. Tanska P, Turunen SM, Han SK, Julkunen P, Herzog W and Korhonen RK. Superficial collagen fibril modulus and pericellular fixed charge density modulate chondrocyte volumetric behaviour in early osteoarthritis. Comput Math Methods Med. 2013;2013:164146. doi: 10.1155/2013/164146. Epub 2013

  44. Kulmala KA, Karjalainen HM, Kokkonen HT, Tiitu V, Kovanen V, Lammi MJ, Jurvelin JS, Korhonen RK and Toyras J. Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking--contribution of steric and electrostatic effects. Med Eng Phys. 2013 Oct;35(10):1415-20. doi: 10.1016/j.medengphy.2013.03.010. Epub

  45. Mononen ME, Jurvelin JS and Korhonen RK. Effects of radial tears and partial meniscectomy of lateral meniscus on the knee joint mechanics during the stance phase of the gait cycle--A 3D finite element study. J Orthop Res. 2013 Aug;31(8):1208-17. doi: 10.1002/jor.22358. Epub 2013 Apr 9.

  46. Mononen ME, Jurvelin JS and Korhonen RK. Implementation of a gait cycle loading into healthy and meniscectomised knee joint models with fibril-reinforced articular cartilage. Comput Methods Biomech Biomed Engin. 2015;18(2):141-52. doi:

  47. Halonen KS, Mononen ME, Jurvelin JS, Toyras J and Korhonen RK. Importance of depth-wise distribution of collagen and proteoglycans in articular cartilage--a 3D finite element study of stresses and strains in human knee joint. J Biomech. 2013 Apr 5;46(6):1184-92. doi: 10.1016/j.jbiomech.2012.12.025. Epub

  48. Turunen SM, Han SK, Herzog W and Korhonen RK. Cell deformation behavior in mechanically loaded rabbit articular cartilage 4 weeks after anterior cruciate ligament transection. Osteoarthritis Cartilage. 2013 Mar;21(3):505-13. doi: 10.1016/j.joca.2012.12.001.

  49. Makela JT, Huttu MR and Korhonen RK. Structure-function relationships in osteoarthritic human hip joint articular cartilage. Osteoarthritis Cartilage. 2012 Nov;20(11):1268-77. doi:

  50. Rasanen LP, Mononen ME, Nieminen MT, Lammentausta E, Jurvelin JS and Korhonen RK. Implementation of subject-specific collagen architecture of cartilage into a 2D computational model of a knee joint--data from the Osteoarthritis Initiative (OAI). J Orthop Res. 2013 Jan;31(1):10-22. doi: 10.1002/jor.22175. Epub 2012 Jul 5.

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